The changes of intestinal microbiota and metabolomics during the inhibition of bladder cancer by liquiritigenin [0.03%]
甘草素抑制膀胱癌过程中肠道微生物组和代谢组的变化规律研究
Zhao Zhai,Jie Fu,Meng-Liang Ye et al.
Zhao Zhai et al.
Liquiritigenin is a natural medicine. However, its inhibitory effect and its potential mechanism on bladder cancer (BCa) remain to be explored. It was found that it could be visualized that the transplanted tumours in the low-dose liquiriti...
Impact of radish seeds (Semen Raphani) on the absorption and transportation of ginsenosides in the Caco-2 cell model: a UPLC-ESI-MS analysis [0.03%]
芜菁种子对人参皂苷在CaCo-2细胞模型中吸收及转运的影响：UPLC-ESI-MS分析
Hui Li,Wen-Shuo Zhang,Rui Liu et al.
Hui Li et al.
This study examined the impact of Semen raphani on the absorption of ginsenosides from Panax ginseng C.A. Meyer (ginseng) using a Caco-2 cell model and Ultra-High-Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectro...
Bithiophene and coumestan derivatives from Eclipta prostrata (L.) L. and their hepatoprotective activity [0.03%]
姜黄科中华泽泻的二噻吩和香豆素类成分及其保肝活性研究
Le Thi Giang,SeonJu Park,Nguyen Thi Cuc et al.
Le Thi Giang et al.
One new bithiophene derivative, 5-(but-3-en-1-yn-1-yl)-5'-(methoxymethyl)-2,2'-bithiophene (1), along with twelve known compounds, senecioester (2), tiglinsaureester (3), 5-acetoxymethyl-2'-(but-3-en-1-yn-1-yl)-2,5'-bithiophene (4), 5-(4-is...
Modeling and biological evaluation of pegmolesatide, a novel and potent erythropoiesis-stimulating agent [0.03%]
一种新型且高效的促红细胞生成素刺激药物pegmolesatide的建模与生物评价
En-Jia Zhou,Xu-Li Lang,Min-Jian Yang et al.
En-Jia Zhou et al.
Pegmolesatide, a synthetic, polyethylene-glycolylated, peptide-based erythropoiesis-stimulating agent (ESA), has been recently approved in China. Pegmolesatide is derived from the structure of endogenous erythropoietin (EPO), a natural prod...
Xiao-Yun Yan,Rui Zhang,Ya-Nan Yang et al.
Xiao-Yun Yan et al.
Three new flavonoids including two isoflavanones sophortones A and B (1 and 2), and one chalcone sophortone C (3) were isolated from the roots of Sophora tonkinensis. Their structures were established by UV, IR, HRESIMS, and NMR data. The a...
Design, synthesis, and anti-oomycete activity of 3-acyloxymaltol/ethyl maltol derivatives [0.03%]
3-酰氧基香豆素/乙基香豆素衍生物的设计、合成及抗菌活性研究
Yi-Hao Guo,Yi-Bo Liu,Ying-Ying Ma et al.
Yi-Hao Guo et al.
Twenty 3-acyloxymaltol/ethyl maltol derivatives (7a-j and 8a-j) were synthesized and evaluated in vitro for their anti-oomycete activity against Phytophthora capsici, respectively. Among all of twenty derivatives, more than half of the comp...
Possible mechanism for the protective effect of active ingredients of astragalus membranaceus on diabetes nephropathy [0.03%]
黄芪活性成分防治糖尿病肾病的机制研究
Yu Li,Jing Wang
Yu Li
Astragali Radix (AR), a common traditional Chinese medicinal herb, exhibits protective effects on diabetic nephropathy (DN) in extensive researches. Aticles focusing on AR in PubMed were collected and reviewed in order to summarize the late...
Three new antinociceptive diterpenoids from the fruits of Rhododendron molle [0.03%]
滇白花丹果三新活性单体化合物研究
Ying-Ying Zhu,Yang-Lan Liu,Bing Chai et al.
Ying-Ying Zhu et al.
Investigation of the fruits of Rhododendron molle G. Don led to the isolation of three new grayanane-type diterpenoids, rhodomolleins LIV-LVI (1-3). The structures and absolute configurations of new compounds were fully elucidated by spectr...
Chen-Xi Zhang,Guang-Hai Zhang,Feng Wei et al.
Chen-Xi Zhang et al.
Phytochemical studies on cigar tobacco leaves led to the isolation of 18 ionone-type compounds, including previously undescribed cigatobanes E (1) and F (2). Additionally, compounds vomifoliol acetate (3), dehydrovomifoliol (4), 8,9-dihydro...
Enantioselective formal total synthesis of dihydrospirotryprostatin B [0.03%]
高选择性全合成光学活性二氢螺_TRY_PRO_statin B分子式DHSpTB
Tian-Feng Peng,Peng Liu,Yu-Xin Guo et al.
Tian-Feng Peng et al.
Spirotryprostatins are representative members of medicinally interesting bioactive molecules of the spirooxindole natural products. In this communication, we present a novel enantioselective total synthesis of the spirooxindole alkaloid dih...