Two new cucurbitane-type triterpenoid saponins from the fruit of Citrullus colocynthis [0.03%]
Citrullus colocynthis果实中的2个瓜儿利定型三萜皂苷成分
Si-Qi Liu,Zi-Ming Feng,Xiang Yuan et al.
Si-Qi Liu et al.
Two new cucurbitane-type triterpenoid saponins, 2,20β,22β-trihydroxy-16α,23(R)-epoxycucurbita-1,5,24-triene-3,11-dione 2-O-β-D-glucopyranoside (1), 2,20β,22α-trihydroxy-16α,23(S)-epoxycucurbita-1,5,11,24-tetraene-3-one 2-O-β-D-gluco...
Discovery of sesquiterpene lactones with anti-inflammatory effect from Youngia japonica [0.03%]
从日本旋覆花中发现具有抗炎作用的倍半萜内酯类化合物
Xian-Sheng Ye,Kuan Lin,Chang-Long Leng et al.
Xian-Sheng Ye et al.
The preliminary study revealed that the ethyl acetate eluate of Youngia japonica (YJ-E) could inhibit the expression of key proteins of p-p65, p-IκBα, p-IKKα/β, and p-AKT in LPS stimulated BV2 cell. Further phytochemical study led to th...
Bao Zhang,Hai-Hua Yuan,Jia Sun et al.
Bao Zhang et al.
Five new glycosides, namely methyl 3-methoxybenzoate-4,5-di-O-β-D-glucopyranoside (1), (1aS,3aS,3R)-3-(4'-O-β-D-glucopyranosyl-3'-methoxyphenyl)-5,6-dioxa-bicyclo[3.3.0]octane-1-one (2), quinolin-4(1H)-one-3-O-β-D-glucopyranoside (3), 3-...
Exploring the mechanism of Si-Miao-Yong-An decoction on heart failure based on molecular docking and network pharmacology [0.03%]
基于分子对接和网络药理学的四妙勇安汤治疗心力衰竭机制探讨
Han Qiu,Sheng-Nan Zhao,Jin-Ling Han et al.
Han Qiu et al.
The SwissTargetPrediction was employed to predict the potential drug targets of the active component of Si-Miao-Yong-An decoction (SMYAD). The therapeutic targets for HF were searched in the Genecard database, and Cytoscape3.9.1 software wa...
Atramacronoid A induces the PANoptosis-like cell death of human breast cancer cells through the CASP-3/PARP-GSDMD-MLKL pathways [0.03%]
Atramacronoid A通过CASP-3/PARP-GSDMD-MLKL途径诱导人乳腺癌细胞类似PANoptosis的细胞死亡
Jing-Rong Li,Ling-Yu Li,Hai-Xin Zhang et al.
Jing-Rong Li et al.
Breast cancer is the most common malignant tumor and a major cause of mortality among women worldwide. Atramacronoid A (AM-A) is a unique natural sesquiterpene lactone isolated from the rhizome of Atractylodes macrocephala Koidz (known as B...
Fuzheng Huayu recipe inhibits bleomycin-induced pulmonary fibrosis in rats by inhibiting M2 polarization of macrophages via the oxidative phosphorylation pathway [0.03%]
扶正化瘀方通过抑制氧化磷酸化解系巨噬细胞M2极化抑制博来霉素诱导的大鼠肺纤维化
Xing-Hua Yuan,Su-Fang Zhang,Yu Hang et al.
Xing-Hua Yuan et al.
Fuzheng Huayu recipe (FZHYR) is a Chinese patent medicine for the treatment of fibrosis. The effects of FZHYR on pulmonary fibrosis and macrophage polarization were investigated in vitro. FZHYR inhibited pulmonary inflammation and fibrosis ...
Sesquilignans PD from Zanthoxylum nitidum var. tomentosum exerts antitumor effects via the ROS/MAPK pathway in liver cancer cells [0.03%]
托多mos藤变种细刺香花活性成分 Sesquilignan PD 通过ROS / MAPK途径对肝癌细胞的抗肿瘤作用
Cai-Wen Fan,Li Luo,Mei-Shan Li et al.
Cai-Wen Fan et al.
Sesquilignans PD is a natural phenylpropanoid compound that was isolated from Zanthoxylum nitidum var. tomentosum. In this study, we assessed the antitumor effect of PD on SK-Hep-1 and HepG2 cells and the underlying molecular mechanisms. Th...
New cembranoid with potent anti-inflammatory effect isolated from Boswellia sacra by inactivating the NF-κB signaling pathway [0.03%]
一种新的莫尔脂环倍半硅氧烷类化合物及其制备方法和应用
Xiao-Rong Yin,Zhen Yuan,Wei-Feng Wang et al.
Xiao-Rong Yin et al.
Boswellia sacra has the properties of activating blood circulation, fixing pain, subduing swelling and promoting muscle growth. However, the anti-inflammatory active ingredients and molecular mechanisms of Boswellia sacra are still not clea...
Lycium barbarum polysaccharides regulate the gut microbiota to modulate metabolites in high-fat diet-induced obese rats [0.03%]
枸杞多糖通过调节肠道菌群诱导高脂饮食大鼠小分子代谢物变化的作用机制研究
Yan-Na Fan,Xi Chi,Lu Yan et al.
Yan-Na Fan et al.
Lycium Barbarum Polysaccharides (LBP) can benefit lipid parameters such as total cholesterol, triglyceride, and high-density lipoprotein levels and upregulate the level of Firmicutes, increase the diversity of gut microbiota and reduce meta...
Mangiferin, a component of Mangifera indica leaf extracts, inhibits lipid synthesis in human sebocytes [0.03%]
mango叶提取物成分芒果酸通过抑制脂质合成来减少人类皮脂细胞中的脂质积累
Da-Min Jung,Sangsoo Lee,Eun-Mi Kim et al.
Da-Min Jung et al.
Inhibition of lipid synthesis in sebocytes is essential for acne treatments. The effects of natural product-derived substances on lipid synthesis are unknown. This study investigated the effects of water extract of Mangifera indica leaves (...