Hao Chen,Sheng-Hong Li,Yong-Xian Cheng
Hao Chen
Five undescribed compounds, including a triterpenoid (1), three phenylpropanoids [(±)-2 and 4], and an aromatic compound (3), as well as six known analogues (5-10), were isolated from the resins of Liquidambar orientalis Mill. Their struct...
Screening of GLP-1r agonists from natural products using affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS technology: a case study of Panax ginseng [0.03%]
基于亲和超滤筛选结合UPLC-ESI-Orbitrap-MS技术的GLP-1受体激动剂筛选及实例研究——以人参为例
Hong-Ping Wang,Zhao-Zhou Lin,Qiong Yin et al.
Hong-Ping Wang et al.
In our study, a method based on affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS technology was established to select Glucagon-like peptide-1 receptor (GLP-1R) agonists from natural products, and as an example, the GLP-1...
Online identification of chemical constituents in Mongolian medicine Zhachong-13 pills by UHPLC-Q-exactive Orbitrap MS [0.03%]
基于UHPLC-Q-exactive Orbitrap MS的蒙古药扎冲十三味丸在线识别化学成分
Cai-Yun Tian,Qing-Rui Yang,Ling-Xuan Fan et al.
Cai-Yun Tian et al.
Zhachong-13 pills (ZC-13), as a traditional prescription of Mongolian medicine, are often used in the clinical practice of Mongolian hospitals for the treatment of stroke and rheumatic arthritis. In this experiment, UHPLC-Q-Exactive Orbitra...
Polyprenylated acylphloroglucinols from Hypericum sampsonii with cytotoxicity against pancreatic carcinomas [0.03%]
hypericum Sampsonii 多戊聚糖酰基茋的抗胰腺癌细胞毒活性研究
Xin-Pei Wang,Xue-Hua Li,Jian-Jun Lei et al.
Xin-Pei Wang et al.
Chemical investigation on the 80% EtOH extract of the air dried aerial parts of Hypericum sampsonii resulted in the isolation of two new polycyclic polyprenylated derivatives, hypersampines A and B (1 and 2). The structures of the new compo...
Harmine inhibits the proliferation and migration and promotes the apoptosis of colon cancer cells via inhibition of the FAK/AKT and ERK1/2/CREB signaling pathways [0.03%]
harmine通过抑制FAK/AKT和ERK1/2/CREB信号通路抑制结肠癌细胞的增殖、迁移并促进其凋亡
Fu-Hong Liu,Xing-Cheng Lin,Yu-Wei Liu et al.
Fu-Hong Liu et al.
Harmine is present in a variety of medicinal plants, and its effects on colon cancer cells remain unclear. Here, we found that harmine exhibited significant inhibitory effects on the proliferation of colon cancer cells by inhibiting the pho...
Guo-Qing Sun,Cheng-En Fu,Yang Yang et al.
Guo-Qing Sun et al.
Three new diterpenoid alkaloids (1, 2, 3) and seventeen known (4-20) compounds were isolated from the whole plant of Delphinium sherriffii Munz (Ranunculaceae). Their structures were elucidated by various spectroscopic analyses, including I...
Schisandrin A can promote the anti-tumor effect of 5-Fu by reversing the immunosuppressive state of the body in rat [0.03%]
五味子甲素通过逆转机体免疫抑制状态增强5-氟尿嘧啶的抗肿瘤效果研究
Xiao-Hui Wang,Peng-Fei Dong,Feng Wang et al.
Xiao-Hui Wang et al.
In this study, based on Walker 256 in vitro experiments, CCK-8 assay, clone formation assay, wound healing assay, and flow cytometry were used to detect cell apoptosis and cell cycle. It was found that schisandrin may have significant anti-...
Chromomycins from soil-derived Streptomyces sp. inhibit the growth of human non-small cell lung cancer cells by targeting c-FLIP [0.03%]
土壤链霉菌产生的色烯霉素通过靶向c-FLIP抑制人非小细胞肺癌细胞的生长
Gao-Jie Li,Chen Wang,Wen-Die Wang et al.
Gao-Jie Li et al.
Three chromomycin derivatives, chromomycins A3 (1, CA3), A5 (2, CA5), and monodeacetylchromomycin A3 (3, MDA-CA3), were identified from the soil-derived Streptomyces sp. CGMCC 26516. A reinvestigation of the structure of CA5 is reported, of...
Mechanisms and therapeutic potential of chinonin in nervous system diseases [0.03%]
秦碱素治疗神经系统疾病的机制及潜在价值研究
Zhang Hui,Wang Lai-Fa,Wang Xue-Qin et al.
Zhang Hui et al.
The flavonoid compound chinonin is one of the main active components of Rhizoma anemarrhena with multiple activities, including anti-inflammatory and antioxidant properties, protection of mitochondrial function and regulation of immunity. I...
Two new diterpenoid alkaloids from the roots of Aconitum nagarum and their cytotoxic activity [0.03%]
Aconitum nagarum根中两种新的二萜类生物碱及其体外细胞毒性作用研究
Jiang Hu,Ren Ji,Guang-Rong Yang et al.
Jiang Hu et al.
A chemical investigation on the roots of Aconitum nagarum afforded two undescribed C19-diterpenoid alkaloids nagarumines D and E (1 and 2). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (1H-1H COS...