Design, synthesis, and antitumor activity of desmosdumotin C analogues [0.03%]
desmosdumotin C类似物的设计、合成及抗肿瘤活性研究
Bin-Yu Wen,Hai Liang,Hong-Ju Guo et al.
Bin-Yu Wen et al.
Desmosdumotin C (Des C), a natural product isolated from the roots of Desmos dumosus, has shown good antitumor activity. A three dimensional quantitative structure-activity relationship (QSAR) study using the comparative molecular field ana...
A new cytotoxic 12-membered macrolactone from the endophytic fungus Exserohilum rostratum LPC-001 [0.03%]
来源于内生真菌Exserohilum rostratum LPC-001的新颖细胞毒12元大环内酯化合物
Peng-Cheng Lin,Yu-Zhuo Wu,Ting-Wen Bao et al.
Peng-Cheng Lin et al.
A new oxacyclododecindione-type macrolactone, (13R,14S,15R)-13-hydroxy-14-deoxyoxacyclododecindione (1), has been obtained from the solid cultures of the fungus Exserohilum rostratum, a fungal strain endophytic in Gymnadenia conopsea. Its s...
Rui Wang,Ling Tong,Cai-Yun Liu et al.
Rui Wang et al.
The phytochemical investigation of the roots of Daphne genkwa yielded six secondary metabolites, including a new flavanol derivative, (2R, 3S)-5,7,4'-trihydroxy-8-methoxycarbonylflavanol (1), and five known compounds (2-6). The molecular st...
Synthesis and in vitro anti-epileptic activities of novel [1,2,4]-triazolo[1,5-a]pyrimidin-7(4H)-one derivatives [0.03%]
新型[1,2,4]三氮唑并[1,5-a]嘧啶-7(4h)-酮衍生物的合成及体外抗惊厥活性研究
Jing Ding,Feng-De Cao,Yan-Ru Geng et al.
Jing Ding et al.
In this investigation, eight novel 2,5-disubstituted [1,2,4]-triazolo[1,5-a]pyrimidin-7(4H)-one and eight novel 2,5-disubstituted [1,2,4]-triazolo[1,5-a]pyrimidine amine derivatives were synthesized based on the novel marine natural product...
Wan-Hua Cui,Yan-Zhi Wang,Ze-Zhi Li et al.
Wan-Hua Cui et al.
Four new diarylheptanoids, (1S, 3R, 5R, 6R)-1, 5-epoxy-3, 6 dihydroxy-1-(4-hydroxy-3, 5-dimethoxyphenyl)-7-(4-hydroxy-3-methoxyphenyl) heptane (1), (1R, 3R, 5S)-1, 5-epoxy-3-acetoxy-1-(4, 5-dihydroxy-3-methoxyphenyl)-7-(3, 4- hydroxyphenyl)...
Hui-Zheng Fu,Yuan-Yu Ma,Shuang-Cheng Ma et al.
Hui-Zheng Fu et al.
Two new iridoid glycosides, callicoside E (1) and callicoside F (2), were isolated from the leaves of Callicarpa nudiflora. Their structures were established by one- and two-dimensional NMR spectroscopy and mass spectrometry. In an in vitro...
Plasma pharmacokinetics of isorhapontigenin, a novel derivative of stilbenes, in mice by LC-MS/MS method [0.03%]
一种新的茋类化合物马兜铃内酯素的小鼠血浆药代动力学研究（LC-MS/MS法）
Ting-Ting Zhang,Ya-Li Wang,Bo Jin et al.
Ting-Ting Zhang et al.
Isorhapontigenin (ISO), a novel derivative of stilbene compound, possessess good pharmacological activities such as antiviral, antioxidant, and anticancer. The purpose of this study is to investigate the pharmacokinetic of ISO in mice plasm...
Diterpenoid glycosides and monoterpenoid glycosides from the fruits of Xanthium chinense [0.03%]
粗沙粒大戟果实中的倍半萜糖苷和单萜糖苷成分研究
Yan Cheng,Jiang Fu,Long Chen et al.
Yan Cheng et al.
Two new diterpenoid glycosides, fructusnoids D (1) and E (2), and two new monoterpenoid glycosides (3, 4), together with three known diterpenoid glycosides (5-7) and three known monoterpenoid glycosides (8-10), were isolated from the fruits...
Straightforward synthesis, characterization, and cytotoxicity evaluation of hybrids of natural alkaloid evodiamine/rutaecarpine and thieno[2,3- d]pyrimidinones [0.03%]
天冬氨酸衍生物与 rutacarpine 类天然生物碱联用的合成、表征及细胞毒性评价
Li-Fei Nie,Si-Si Wang,Jian-Guo Cao et al.
Li-Fei Nie et al.
Dozens of hybrids of natural alkaloid evodiamine/rutaecarpine and thieno[2,3-d]pyrimidinones were synthesized in a straightforward method by condensation of substituted 2H-thieno[2,3-d][1, 3]oxazine-2,4(1H)-diones or N-methyl-2H-thieno[2,3-...
Bioactive megastigmane glucosides and monoterpenes from Lyonia ovalifolia [0.03%]
卵叶越桔中的生物活性Megastigmane糖苷和单萜类化合物
Xiao-Jing Lv,Yong Li,Shuang-Gang Ma et al.
Xiao-Jing Lv et al.
Three new megastigmane glucosides (1-3) and two new monoterpenes (4-5), together with 14 related known compounds (6-19) were isolated from the twigs and leaves of Lyonia ovalifolia. The structures of the new compounds were determined by ext...