Chuan-Hou Li,Guang-Hui Jiang,Jing-Chun Yao et al.
Chuan-Hou Li et al.
Two novel polyacetylenic compounds were successfully separated from the dichloromethane extract of the aerial parts of Bidens parviflora Willd., known for its ethnomedicinal use in traditional Dai medicine. These compounds were structurally...
A demethylation chloroisosulochrin and a chromone metabolite from the endophytic fungus Penicilium sp [0.03%]
来自内生真菌Penicilium菌的氯异硫康素脱甲基化和一种色原酮代谢物
Ke-Liang Chen,Xue Wang,Yang Liu et al.
Ke-Liang Chen et al.
A newly discovered chloroisosulochrin derivative, involving demethychloroisosul (1), and a novel chromone metabolite, reduchromone (2), were extracted from Penicilium sp., an endophytic fungus residing in Rhododendron molle. The structures ...
A new verrucosane diterpenoid from the Vietnamese liverwort Plagiochila bantamensis [0.03%]
采自越南的植物膜叶蘚中的一种新的 verrucosane 二萜化合物
Le Thi-Kim-Dung,Nguyen Thi-Nhu-Quynh,Le Thanh-Nguyen et al.
Le Thi-Kim-Dung et al.
A new verrucosane-type diterpenoid, bantamenside (1), along with six known compounds (2-7), was isolated from the Vietnamese liverwort Plagiochila bantamensis. The structure of the new compound was determined using comprehensive spectroscop...
First total synthesis and antimicrobial evaluation of xanthone V1 [0.03%]
天然黄酮类化合物Xanthone V1的全合成及生物活性研究
Fei Tan,Meng-Qi Wang,He-Fei Shi et al.
Fei Tan et al.
Antibiotic resistance demands new agents. We disclosed the first total synthesis of the natural xanthone V1 (1), which featured a regioselective Claisen cyclization and a Claisen/Cope rearrangement that installed the pyran ring and isopente...
Unraveling the mechanisms of matrine in esophageal cancer treatment: insights from network pharmacology, bioinformatics, and molecular biology experiments [0.03%]
网络药理学、生物信息学和分子生物学实验探究小檗胺抗食管癌的作用机制
Si-Min Wen,Ting Lv,Lei Lei et al.
Si-Min Wen et al.
Matrine, a natural compound from traditional Chinese medicine, demonstrates anti-esophageal cancer (EC) efficacy via multi-target mechanisms. In this study, integrated network pharmacology and WGCNA identified MGLL, EPHX2, and CES2 as key t...
Effects of bergapten-loaded long-circulating liposomes on osteogenic differentiation of human dental pulp stem cells [0.03%]
补骨脂素载药长效脂质体对人牙髓干细胞成骨分化的效应研究
Hao-Nan Ding,Xu-Wen Wang,Yu-Xin Qian et al.
Hao-Nan Ding et al.
Bergapten is a natural compound with the potential to regenerate bone. However, its poor solubility and instability hinder its clinical use. We developed bergapten-loaded long-circulating liposomes (BP-LCL) to overcome these challenges. The...
Isolation and structural characterization of an iridoid glycoside and a pyridine derivative, both previously undescribed, from the flowers of Rhododendron decorum [0.03%]
从映山红(Rhododendron decorum)花中分离并结构表征一种新的环木脂素类化合物及其他两种茋类衍生物
Zhang Hou-Run,Cheng Qi,Dong-Bao Hu et al.
Zhang Hou-Run et al.
An iridoid glycoside, rhododeoside C (1), and a pyridine derivative, rhododeodine A (2), both previously undescribed, were isolated from the flowers of Rhododendron decorum. The structures were elucidated using 1D and 2D NMR spectroscopy, a...
A new cyclohexenone and two new phenanthrones from Elatostema tenuicaudatum [0.03%]
毛梗猕猴桃中的一个环己烯酮和两个菲蒽酮化合物
Dao Duc Thien,Nguyen Hoang Sa,Le Quoc Thang et al.
Dao Duc Thien et al.
A new cyclohexenone, 5S-(3,4-dihydroxyphenethyl)cyclohex-2-en-1-one (1), along with two new phenanthrones, (4aS,10aS)- 1,9,10,10a -tetrahydro-4a,6,7-trihydroxy-4(4aH)-phenanthrone (2) and (4aS,10aS)-4a-hydroxy-7-methoxy-1,9,10,10a-tetrahydr...
Synthesis and anti- Candida albicans activity of oleanolic acid derivatives [0.03%]
乌索酸衍生物的合成及对白色念珠菌活性测试研究
Fei Zou,Lu-Yi Jiang,Fei Chen et al.
Fei Zou et al.
With the increase incidence of Candida albicans infections and the widespread use of azole drugs, particularly fluconazole, the emergence of drug-resistant strains has become a significant concern. In this study, the derivatives were prepar...
Hyperwightianols I-N, six new meroterpenoids from Hypericum wightianum [0.03%]
来自Hypericum wightianum的6个新的杂萜类化合物hyperwightianol I-N
Chuan-Lu Fu,Ping Ying,Wei-Ming Huang et al.
Chuan-Lu Fu et al.
Six undescribed meroterpenoids, designated as hyperwightianols I-N (1-6), were isolated from the dried whole herb of Hypericum wightianum. The structures of these compounds were elucidated through comprehensive spectroscopic analyses, inclu...