Novel antimicrobial defensin peptides from different coleopteran insects (Coleoptera: Insecta): identification, characterisation and antimicrobial properties [0.03%]
甲虫属节肢动物的新型抗菌肽：鉴定、分类及抗菌特性
Ayşe Nur Pektaş,Ertan Mahir Korkmaz
Ayşe Nur Pektaş
Antimicrobial peptides are crucial components of the immune systems of both vertebrates and invertebrates. Here, defensins, the most studied class of antimicrobial molecules in arthropods were investigated in four coleopteran insect species...
Yi-Lin Wu,Min-Jian Dong,Cheng-Xin Sun et al.
Yi-Lin Wu et al.
Seven flavanol derivatives, including three biflavanoids (1-3), two flavonoids (4 and 5), and two spirobiflavonoids (6 and 7), were isolated from the bark of Nothotsuga longibracteata. The structure of the undescribed compound 1 was elucida...
Compound FLZ attenuates neuroinflammation through inhibiting Src/PTEN/Akt signaling pathway [0.03%]
复合氟嗪酸通过抑制Src/PTEN/Akt信号通路减轻神经炎症
Fang-Fang Li,Yuan-Peng Zheng,Gen Li et al.
Fang-Fang Li et al.
Compound FLZ has neuroprotective effects on Parkinson's disease (PD), while the precise mechanism remains unclear. In this study, we found that FLZ decreased PTEN/Akt activity in LPS-challenged BV2 cells. Neuroinflammatory responses suppres...
Three new terpenoid derivatives from the deep-sea-derived fungus Aspergillus sydowii DFFSCS007 [0.03%]
来源于深海真菌Aspergillus sydowii DFFSCS007的3个倍半萜衍生物
Xu-Meng Ren,Ke-Yue Wu,Shu-Hua Qi
Xu-Meng Ren
Three new terpenoid derivatives (1S,6R,7S)-hydrobenzosydowic acid (1), (1 R,6S,7S)-hydrobenzosydowic acid (2), and (7 R,10R)-11-dehydroxy-iso-10-hydroxysydowic acid (3), along with the known analogues (S)-2-(1-(4-nitrobenzoyl)pyrrolidine-2-...
Shi-Jie Zhong,Ya-Dong Xing,Lu-Yao Dong et al.
Shi-Jie Zhong et al.
Curcumin has diverse biological functions, especially antioxidant and anti-inflammatory properties, but clinical trials have been hindered by its low bioavailability and pharmacokinetic properties. To achieve therapeutic efficacy, understan...
Meroterpenoids from Rhododendron racemosum and their anti-inflammatory activities [0.03%]
杜鹃素对马兜铃的影响及其抗炎活性
Si-Xuan Liu,Si-Yang Dai,Yong-Fu Lu et al.
Si-Xuan Liu et al.
Three meroterpenoids, including one new compound, ranhuadujuanine E (1), one new natural product, methyl (E)-3-(3,7-dimethylocta-2,6-dien-1-yl)-2,4-dihydroxy-6-methylbenzoate (2), and one known compound, ranhuadujuanine D (3), along with tw...
Urolithin B inhibits LPS-induced macrophage M1 polarization via miR155-5p mediated MAPK/NF-кB pathway [0.03%]
尿石素B通过miR155-5p介导的MAPK/NF-κB途径抑制LPS诱导的巨噬细胞M1极化作用
Wulipan Tuohudaali,Teng-Fei Ji,Wan-Ting Ding et al.
Wulipan Tuohudaali et al.
This study investigated inhibiting mechanisms of Urolithin B (Uro B) on macrophage M1 polarization. Uro B (50 μM) could inhibit the PGE2, COX-2, NO, iNOS, TNF-α, IL-1β and IL-6 levels compared with model group (P < 0.05) as well as the C...
Tripterygium wilfordii polyglycoside tablets attenuated the progression of hepatocellular carcinoma by targeting IL-6 and downstream signaling pathways in a multi-target manner [0.03%]
雷公藤多苷通过多靶点抑制白细胞介素-6及其下游信号通路逆转肝癌细胞恶性表型的作用机制研究
Pei-You Ren,Jian-Ying Zhang,Lei Zhao et al.
Pei-You Ren et al.
Tripterygium wilfordii polyglycoside tablets (TWPT) have traditionally been used to treat certain inflammatory diseases. This study validated TWPT as a novel application in hepatocellular carcinoma treatment through multiple targets, thereb...
Exploring the therapeutic potential of Annona reticulata extract: molecular docking, dynamics, and ADMET properties for cancer treatment and anti-inflammatory activity [0.03%]
annonareticulata提取物治疗潜力的研究：分子对接、动力学及药物性质对癌症治疗和抗炎活性的影响
Pratheep Thangaraj,Ekambaram Gayathiri,Palanisamy Prakash et al.
Pratheep Thangaraj et al.
Colorectal cancer remains a global health challenge, prompting the exploration of natural compounds for treatment. Annona reticulata shows promise as a source of activity biomolecules. This study analyzed the dynamics, molecular docking and...
Characterization of metabolic profile of Dazhu Hongjingtian and evaluation of its anti-hypoxic constituents [0.03%]
大珠红景天代谢轮廓特征及抗缺氧成分评价
Chun-Yan Ou,Xia Gao,Jia-Jia Wang et al.
Chun-Yan Ou et al.
Dazhu Hongjingtian (DZ) is renowned for its diverse pharmacological activities, yet its metabolic pathways remain to be fully elucidated. In this study, the metabolic profile after oral administration of DZ extract (DZE) in rats was systema...