Polypharmacy and clinical outcomes in geriatric patients with metastatic hormone-sensitive prostate cancer treated with androgen receptor pathway inhibitors [0.03%]
新确诊转移性激素敏感前列腺癌接受口服雄激素受体通路抑制剂治疗的老年人中处方药使用对其临床结局的影响
Tanju Kapagan,Nilufer Bulut,Ulviye Oflas et al.
Tanju Kapagan et al.
ObjectiveThis study aimed to evaluate the prevalence of polypharmacy and its association with clinically significant adverse events in geriatric patients (≥65 years) with metastatic hormone-sensitive prostate cancer (mHSPC) receiving andro...
Therapeutic potential of aspirin in metastatic brain disease: A narrative review bridging evidence from systemic cancers to brain metastasis [0.03%]
阿司匹林在转移性脑疾病中的治疗潜力：一篇结合全身癌症到脑转移证据的叙述性评论
Nour Kenaan,Mohammad Al Aboud,Tala Jaber et al.
Nour Kenaan et al.
BackgroundAcetylsalicylic acid (aspirin) is a widely used medication with antipyretic, anti-inflammatory, and antiplatelet effects. It also exhibits antitumor properties by enhancing immune responses, downregulating proinflammatory cytokine...
Incidence of neutropenia with intrathecal pemetrexed for leptomeningeal disease associated with solid tumors - A retrospective analysis [0.03%]
与实体瘤相关的脑膜疾病的培美曲塞腰椎给药导致中性粒细胞减少的发病率-一项回顾性分析
Nicholas D Ngo,Anshika Singh,Scott Hampton et al.
Nicholas D Ngo et al.
BackgroundLeptomeningeal disease is a complication of advanced solid tumors, and treatment options are limited by inadequate central nervous system penetration. Intrathecal pemetrexed has emerged as an off-label therapeutic option. However,...
Bridging the pain gaps: Opioid access for cancer pain in rural Nepal and the untapped role of pharmacists [0.03%]
架起止痛之桥：尼泊尔农村地区阿片类药物的可及性与发挥药师作用的重要性以缓解癌痛问题
Sunil Shrestha,Rajeev Shrestha,Sundus Shukar et al.
Sunil Shrestha et al.
Low fixed dose rasburicase for tumour lysis syndrome prophylaxis and treatment is feasible and efficacious in the management of haematologic malignancies [0.03%]
低剂量固定方案的 rasburicase 用于预防和治疗肿瘤溶解综合征在血液系统恶性肿瘤中的可行性和有效性研究
Taylor Mackie,Joshua Tobin,Vivien Chan et al.
Taylor Mackie et al.
IntroductionRasburicase is a high-cost medicine indicated for the prevention and treatment of tumour lysis syndrome (TLS). Growing evidence supports low fixed-dose rasburicase regimens (3-6 mg), however, uncertainty remains regarding their ...
Failure mode and effects analysis of hazardous drugs preparation workflows using isolators with contextual evaluation of laminar airflow cabinets in hospital pharmacy [0.03%]
使用隔离器进行危险药物配制工作流程的失效模式及影响分析，并对医院药房中层流洁净操作台进行上下文评估
Seham El Deeb,Ali Cherif Chefchaouni,Imane Toughrai et al.
Seham El Deeb et al.
BackgroundHazardous drugs preparation is a high-risk process requiring strict control of aseptic conditions to ensure product sterility and to protect healthcare workers. Isolators and laminar airflow cabinets are widely used in hospital ph...
Exploring the perspective of healthcare professionals about cachexia in cancer patients; A qualitative study [0.03%]
从医疗保健专业人员的角度探讨癌症患者恶病质的观点——一项定性研究
Maryam Khalid,Zunaira Akbar,Safeer Khan et al.
Maryam Khalid et al.
BackgroundCancer cachexia is a complex metabolic syndrome that causes a gradual loss of skeletal muscle mass that cannot be fully reversed by normal nutritional support. It has considerable impact on patient's health, but it is still not we...
H3K27M-mutant diffuse midline glioma pharmacotherapy: Clinical evidence and practice implications of dordaviprone [0.03%]
携带H3K27M突变的弥漫性中线胶质瘤药物治疗：dordaviplone临床证据及实践意义
Zachary J Nuss,Christian DeYoung,Derick Gross
Zachary J Nuss
ObjectiveTo evaluate current pharmacotherapeutic strategies for H3 K27M-mutant diffuse midline glioma (DMG), with emphasis on the clinical evidence for dordaviprone, its place in therapy, and its implications for oncology practice.Study Sel...
Efficacy and safety of sacituzumab govitecan in hormone receptor-positive metastatic breast cancer: A systematic review and meta-analysis [0.03%]
司妥昔单抗戈维替坎在激素受体阳性转移性乳腺癌中的疗效和安全性：系统评价和 Meta 分析
Ali Kaan Güren,Muhammed Fatih Kırcalı,Murat Sarı et al.
Ali Kaan Güren et al.
BackgroundSacituzumab govitecan (SG) has shown clinical activity in hormone receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer (HR+/HER2- MBC), although evidence remains limited and heterogeneous. W...
Clinical characteristics and risk factors for pomalidomide-induced skin rash: Implications for pharmacist-led monitoring in real-world multiple myeloma care [0.03%]
来那度胺引起皮肤不良反应的临床特征和危险因素：药学监护真实世界下的多发性骨髓瘤患者的启示——泊马利单抗诱导的皮肤疹的临床特征及风险因素：对药房监护的实际意义
Tomiyuki Sugi,Ryouta Kushi,Homare Hanai et al.
Tomiyuki Sugi et al.
BackgroundPomalidomide (POM) can cause skin rash, although it is generally considered less frequent than lenalidomide (LEN)-induced rash. However, skin rash remains a clinically relevant adverse event that may lead to treatment interruption...