Effect of grape seed extract on doxorubicin-induced testicular and epididymal damage in rats [0.03%]
葡萄籽提取物对阿霉素所致大鼠睾丸和附睾损害的影响
Emine Sarman,Halit Bugra Koca
Emine Sarman
IntroductionDoxorubicin (DXR), a chemotherapeutic antibiotic, is widely used as an anticancer drug in clinics. Grape seed extract is known for its potent antioxidant properties. The aim of this study is to investigate the effect of high-ant...
Pedunculoside inhibits cardiomyocyte inflammatory biomarkers via Nrf2/HO-1 pathway in high glucose-induced H9c2 cells and diabetic cardiomyopathy model rats [0.03%]
Pedunculoside通过Nrf2/HO-1通路抑制高糖诱导的H9c2细胞和糖尿病心肌病模型大鼠的心肌炎性生物标志物
Yuanben Lu,Jianqiang Meng,Dewen Zhu et al.
Yuanben Lu et al.
IntroductionDiabetic cardiomyopathy (DCM) is a complication of diabetes mellitus (DM) that can lead to heart failure and increase the risk of mortality. Pedunculoside (PE), a novel triterpenoid saponin, exhibits anti-inflammatory and anti-o...
KLF9 mediates NLRP3 inflammasome and reactive oxygen species to mediate pyroptosis in trophoblasts [0.03%]
KLF9介导的NLRP3炎性体和活性氧介导滋养层细胞的焦亡过程
Qian Li,Min Chen
Qian Li
IntroductionThe objective of this study was to explore the effect of KLF9 on oxidative stress (OS) and NLRP3-mediated inflammation in preeclampsia (PE).MethodsLipopolysaccharide (LPS)+adenosine triphosphate (ATP)-induced HTR-8/SVneo cells w...
Integrated gut microbiota and serum metabolomics reveal glyphosate-induced hepatic injury in mice [0.03%]
肠道微生物组和血清代谢组的整合分析揭示了草甘膦诱导的小鼠肝脏损伤
Gang Li,Yu Cheng,Xiaolei Yang et al.
Gang Li et al.
IntroductionGlyphosate (GLP) is one of the most widely used herbicides in the world. However, its underlying effects on the liver remain unclear. This study aims to investigate the toxic effects and the gut microbiome- and serum metabolite-...
Insights into therapeutic potential and practical applications of natural toxins from poisonous mushrooms [0.03%]
毒蘑菇天然毒素的治疗潜力和实际应用新见解
Tharuka Wijesekara,Baojun Xu
Tharuka Wijesekara
IntroductionMushrooms, belonging to the phyla Ascomycota and Basidiomycota, comprise approximately 14,000 known species, among which a small fraction are toxic. While toxic mushrooms are primarily associated with adverse health effects, rec...
Rhynchophylline promotes microglia phenotypic transformation and repair of cerebral ischaemic injury through the JAK2/STAT3 pathway [0.03%]
紫杉酚通过JAK2/STAT3通路促进小胶质细胞表型转化及脑缺血损伤修复作用
Peng Bai,Caixia Li,Luwei Yin et al.
Peng Bai et al.
Background: Rhynchophylline (RIN) is an alkaloid known for its ability to effectively block signal transduction related to various neurodegenerative diseases. However, the specific mechanism by which RIN regulates microgl...
Activation of SIRT3/AMPK/mTOR-mediated autophagy promotes quercetin-induced ferroptosis in oral squamous cell carcinoma [0.03%]
SIRT3/AMPK/mTOR介导的自噬活化促进黄酮诱导口腔鳞状细胞癌的铁死亡
Jin Wang,Jia-Hui Yang,Di Xiong et al.
Jin Wang et al.
Introduction: Quercetin has been reported to inhibit the growth of oral squamous cell carcinoma (OSCC), but the mechanism remains unclear. Therefore, our study aimed to investigate the involvement of sirtuin 3 (SIRT3) and...
The acute and sub-chronic toxicological effects of 3-amino-9-ethylcarbazole (AEC) on zebrafish [0.03%]
3-氨基-9-乙基咔唑(AEC)对斑马鱼的急性和亚慢性毒性效应研究
Erna Vásárhelyi,Gergely Rácz,Béla Urbányi et al.
Erna Vásárhelyi et al.
Introduction: In this study, we sought to determine the sub-chronic toxicological effects of AEC on zebrafish embryos. Methods: We util...
Enhancing breast cancer treatment: Evaluating the efficacy of hyaluronic acid-coated tamoxifen-loaded solid lipid nanoparticles on MCF7 cells [0.03%]
提高乳腺癌治疗效果：评估透明质酸涂层的固态脂质纳米颗粒加载他莫昔芬在MCF7细胞中的疗效
Niloufar Ghayoumipour,Hossein Ghafouri
Niloufar Ghayoumipour
Introduction: Tamoxifen (TMX) shows promise in treating breast cancer, but it faces challenges such as poor solubility, instability, and incomplete release when targeting tumors. Additionally, TMX therapy's toxicity is a ...
Conflicts of interest in the International Agency for Research on Cancer process of identifying carcinogenic hazards to humans [0.03%]
国际癌症研究机构在确定人类致癌物过程中产生的利益冲突问题
Susan A Elmore,Colin Berry,Brad Bolon et al.
Susan A Elmore et al.
Managing conflicts of interest (COIs) in scientific decision-making is important for minimizing bias and fostering public trust in science. Proper management of COIs has added significance when scientists are making decisions that impact pu...