Hydrogen attenuates the senescence of adipose-derived stem cells and enhances their myogenic differentiation via modulation of the PRDX6/SIRT1/PGC-1α signaling pathway [0.03%]
氢气通过调节PRDX6/SIRT1/PGC-1α信号通路减轻脂肪来源干细胞衰老并增强其肌生成分化能力
Pei Zhang,Yanmin Hu,Wenkang Liu et al.
Pei Zhang et al.
IntroductionAdipose-derived mesenchymal stem cells (ADSCs) are promising candidates for regenerative therapies, but their clinical application is limited by cellular aging. This study investigated the effects of hydrogen on ADSC senescence ...
Nifuroxazide attenuated 5-fluorouracil-induced cardiac intoxication by regulating NLRP3/STAT-3, PPAR-γ, and apoptosis signals [0.03%]
尼福羅沙紫通过调节NLRP3/STAT-3、PPAR-γ和凋亡信号来缓解5-氟尿嘧啶致心脏毒性作用
Nouf S Al-Abbas,Nehad A Shaer
Nouf S Al-Abbas
IntroductionFor many years, 5-fluorouracil (5-FU) has been utilized as a chemotherapeutic treatment for a variety of malignancies. Unfortunately, 5-FU causes cardiotoxicity, which restricts its clinical use. Nifuroxazide (NFX) is a STAT-3 i...
Pelargonidin-3-O-glucoside prevents isoproterenol-induced myocardial infarction via modulating cardiac and inflammatory markers expression in experimental rats [0.03%]
花青素-3-葡萄糖苷通过调节心脏及炎症指标的表达预防异丙肾上腺素致大鼠心肌梗死作用机制研究
Jianmei Chang,Xiaoling Guo,Peng Hou
Jianmei Chang
IntroductionThis study examined the cardioprotective effects of Pelargonidin-3-O-glucoside (Pg3G) against myocardial infarction induced by isoproterenol (ISO) in male Wistar rats.MethodsAnimals were divided into four groups each groups cont...
Targeted inhibition of STING-TBK1 axis alleviates the hepatotoxicity of tripterygium glycosides [0.03%]
靶向抑制STING-TBK1信号轴可缓解雷公藤内酯醇的肝毒性
Ting Yang,Tian Ma,Huanhuan Zhang et al.
Ting Yang et al.
IntroductionThis study aimed to investigate the mechanisms underlying Tripterygium glycosides (TG) - induced liver injury, focusing on the role of the STING-TBK1 signaling pathway, and to evaluate the therapeutic potential of inhibiting thi...
The impact of KIAA1429 on proliferation and invasion in oral cancer via LINC00958 methylation [0.03%]
KIAA1429通过LINC00958甲基化对口腔癌增殖和侵袭的影响
Pengjun Zhou,Wanning Li,Meiyi Ye et al.
Pengjun Zhou et al.
IntroductionThe investigation focused on the function of LINC00958 in the development of oral cancer, as well as the influence of methylation on tumor formation.MethodsTo explore the role of LINC00958, both its overexpression and its methyl...
Rosa roxburghii tratt juice mitigates diosbulbin B-induced hepatotoxicity through autophagy regulation [0.03%]
Rosa roxburghii tratt果汁通过调节自噬减轻Diosbulbin B诱导的肝毒性
Yuhong Zhang,Xingcan Yang,Maoyuan Gong et al.
Yuhong Zhang et al.
IntroductionDiosbulbin B (DB) has emerged as a potential drug for tumor treatment, but its hepatotoxicity restricts clinical use. The role of autophagy in DB-induced liver damage remains unclear. This study investigates autophagy mechanisms...
Robinin attenuates cardiac hypertrophy in pulmonary heart disease by modulating SIRT1/NF-κB signaling and inhibiting oxidative stress and the NLRP3 inflammasome [0.03%]
robinin通过调节SIRT1/NF-κB信号通路并抑制氧化应激和NLRP3炎性小体来缓解肺心病心脏肥大
Chao Wang,Lei Qin,Xinrui Zhang et al.
Chao Wang et al.
BackgroundRobinin possesses certain antioxidative and anti-inflammatory properties. However, its mechanisms of action in cardiac hypertrophy (CH) and fibrosis remain inadequately explored.MethodsAn in vitro model of CH was established using...
Clinical and laboratory prognostic factors associated with methanol toxicity outcomes in patients at Tabriz Sina Hospital: A retrospective study [0.03%]
塔布里兹西娜医院甲醇中毒患者预后相关临床及实验室指标：一项回顾性研究
Sajjad Ahmadi,Ali Ostadi,Hadi Chitsazi et al.
Sajjad Ahmadi et al.
IntroductionMethanol toxicity is a significant health concern with potentially severe outcomes. This study aimed to investigate the prognostic factors of patients with methanol toxicity referred to Tabriz Sina Hospital.MethodsA descriptive-...
Protective effects of Tribulus Terrestris extract on cisplatin-induced ovarian damage: Antioxidants and anti-inflammatory insights [0.03%]
唐松草提取物对顺铂致卵巢损伤的保护作用：抗氧化与抗炎机制研究
Morteza Abdi,Hadi Karimzadeh,Amirreza Jourabchi et al.
Morteza Abdi et al.
BackgroundCisplatin (CIS) is a widely used chemotherapeutic agent; however, it is associated with ovarian toxicity. Tribulus Terrestris (TT) is recognized for its antioxidant and anti-inflammatory properties. This study aims to evaluate the...
Establishment and validation of an in vitro liver model based extracellular matrix for hepatotoxicity prediction [0.03%]
基于体外肝脏模型的细胞外基质的建立和验证用于肝毒性预测
Yue Yu,Haodong Zhong,Qianyi Niu et al.
Yue Yu et al.
IntroductionThree-dimension (3D) cell culture presents a promising alternative of drug-induced liver injury (DILI). To advance preclinical toxicology research, we developed an in vitro liver model using HepG2 for toxic evaluation.MethodsThe...