Base deficit is a predictor of mortality in organophosphate insecticide poisoning [0.03%]
有机磷中毒时，碱缺乏量可预测死亡率
S B Lee,C Kang,D H Kim et al.
S B Lee et al.
Objective: Organophosphate insecticide (OPI) self-poisoning is a major medical problem in many countries. Several studies have demonstrated that the base deficit (BD) is a prognostic tool that is correlated with the sever...
Observational Study
Human & experimental toxicology. 2018 Feb;37(2):118-124. DOI:10.1177/0960327117694073 2018
Influence of age on arsenic-induced behavioral and cholinergic perturbations: Amelioration with zinc and α-tocopherol [0.03%]
年龄对砷诱导的行为和胆碱能紊乱的影响：锌和α-生育酚的改善作用
M R Kumar,G R Reddy
M R Kumar
This study was planned to determine arsenic (As) (10 mg/kg body weight given through oral gavage) induced behavioral and cholinergic perturbations in three different age groups of rats; young (postnatal day 21), adult (3 months), and aged (...
Comparative Study
Human & experimental toxicology. 2018 Mar;37(3):295-308. DOI:10.1177/0960327117698540 2018
The impact of laboratory chow for rats in the experiments: Chemical and biological evaluation of nine grain-based diet options [0.03%]
基于谷物的九种饲料对实验大鼠的影响：化学和生物评估
R S Ferreira,L de Souza Morelini,Emc de Azeredo et al.
R S Ferreira et al.
Cereal-based diets formulated as semi-purified diets can provide flexibility for researchers, enabling open controlled formulas, besides being cheaper than purified diets. Seeking to widen the researchers' options in their experimental desi...
Comparative Study
Human & experimental toxicology. 2018 Mar;37(3):275-284. DOI:10.1177/0960327117695637 2018
Molecular hepatoprotective effects of lipoic acid against carbon tetrachloride-induced liver fibrosis in rats: Hepatoprotection at molecular level [0.03%]
硫辛酸对四氯化碳所致大鼠肝纤维化的分子肝保护作用：分子水平的肝脏保护作用
K M Sadek,E A Saleh,S M Nasr
K M Sadek
Background: Liver fibrosis is a noteworthy well-being issue that can prompt the progression of liver cirrhosis and hepatocellular carcinoma. Prominently, many antioxidants have been shown to have defensive impacts against...
Therapeutic effects of oral liothyronine on aluminum phosphide poisoning as an adjuvant therapy: A clinical trial [0.03%]
口服三碘甲状腺原氨酸联合治疗铝磷中毒的临床疗效研究
M H Goharbari,F Taghaddosinejad,M Arefi et al.
M H Goharbari et al.
Background: In aluminum phosphide (AlP) poisoning, death is mainly due to cardiovascular failure and refractory acute heart failure. There is a lot of evidence showing thyroid hormones have cardioprotective effects. ...
Randomized Controlled Trial
Human & experimental toxicology. 2018 Feb;37(2):107-117. DOI:10.1177/0960327117694074 2018
Effects of phosphodiestrase type 5 inhibitors in epinephrine-induced arrhythmia in rats: Involvement of lactate dehydrogenase and creatine kinase downregulation and adiponectin expression [0.03%]
一氧化氮供体及磷酸二酯酶5型抑制剂对抗肾上腺素诱发的大鼠心律失常：乳酸脱氢酶与肌酸激酶下调及脂蛋白脂肪酸因子表达的介导作用
Aaa Salama,R E Mostafa,E A Omara
Aaa Salama
Cardiac arrhythmia is a common cause of mortality, and its progression may be due to abnormal sympathetic nerve activity and catecholamine release. Besides, lactate dehydrogenase (LDH) and creatine kinase (CK) downregulation and adiponectin...
Evaluation of 4-methyl-2-[(2-methylbenzyl) amino]-1,3-thiazole-5-carboxylic acid against hyperglycemia, insulin sensitivity, and oxidative stress-induced inflammatory responses and β-cell damage in the pancreas of streptozotocin-induced diabetic rats [0.03%]
4-甲基-2-[[（2-甲基苯基）乙烯基]氨基]-1，3-噻唑-5-甲酸对链脲佐菌素诱导的糖尿病大鼠高血糖、胰岛素抵抗及氧化应激引起的胰腺β细胞损伤和炎症反应的影响研究
Y N Paudel,M R Ali,S Bawa et al.
Y N Paudel et al.
4-Methyl-2-[(2-methylbenzyl) amino]-1,3-thiazole-5-carboxylic acid (bioactive compound (BAC)), a novel thiazole derivative, is a xanthine oxidase inhibitor and free radical scavenging agent. Effects of BAC on hyperglycemia, insulin sensitiv...
Amitriptyline modulated Ca2+ signaling and induced Ca2+-independent cell viability in human osteosarcoma cells [0.03%]
阿米替林调节钙离子信号并诱导人类骨肉瘤细胞的非钙依赖性细胞活力
T Lu,C-T Chou,W-Z Liang et al.
T Lu et al.
Amitriptyline is a widely used tricyclic antidepressant, which acts primarily as a serotonin-norepinephrine reuptake inhibitor. This study examined the effect of amitriptyline on Ca2+ homeostasis and its related mechanism in MG63 human oste...
Development of a data-processing method based on Bayesian k-means clustering to discriminate aneugens and clastogens in a high-content micronucleus assay [0.03%]
一种基于Bayesian k-均值聚类的判别有丝分裂毒性和断裂毒性数据处理方法的发展及应用高内涵微核实验研究
Z H Huang,N Li,K F Rao et al.
Z H Huang et al.
Genotoxicants can be identified as aneugens and clastogens through a micronucleus (MN) assay. The current high-content screening-based MN assays usually discriminate an aneugen from a clastogen based on only one parameter, such as the MN si...
Investigation of hypersensitivity potential of diacetyl by determining cytokine profiles [0.03%]
通过确定细胞因子谱型调查二乙酰的过敏倾向性
A Elkama,O C Ulker,E Teker et al.
A Elkama et al.
Exposure to chemicals in workplace settings leads to significant occupational diseases related to hypersensitivity reactions. In recent years, diacetyl which is used as a food additive is thought to be as an important hazard due to its sens...