Aoife Martin,Lisa Kennedy,Ishita Solanki et al.
Aoife Martin et al.
2,5-Disubstituted pyrrolidines were synthesised from ketoenone substrates using a transaminase-triggered intramolecular aza-Michael reaction in moderate to good yields. The pyrrolidines were isolated as mixtures of diastereoisomers and a no...
A pre-synthetic conjugation methodology of DNA and RNA: combining on-column conjugation and tandem oligonucleotide synthesis [0.03%]
DNA和RNA的预合成连接方法学：结合柱上偶联及串联寡核苷酸合成技术
Jagandeep S Saraya,Derek K O&#x;Flaherty
Jagandeep S Saraya
Amino modifiers are valuable chemical tools for nucleic acid bioconjugation applications and for probing potential mechanisms relevant to the origins of life. Herein, we describe a streamlined and cost-effective strategy for the incorporati...
Zeyuan Zhao,Jun Guo,Xiang Wang et al.
Zeyuan Zhao et al.
Here, we reported a novel and efficient method for the synthesis of S-alkyl substituted sulfilimines by employing a base-promoted ring-opening reaction of sulfonium salts with sulfenamides. This reaction proceeds smoothly under transition m...
Wanqi Hu,Xingyu Chen,Xiaowei Wu
Wanqi Hu
Herein, we report an iron-catalyzed transylidation reaction between sulfides and iodonium ylides for the efficient synthesis of S,C-sulfonium ylides under mild and environmentally friendly conditions. The approach employs an inexpensive iro...
Adapting Bower's intramolecular aziridination reaction allows for a metal-free synthesis of N-H aziridines [0.03%]
适应Bower的分子内氮丙啶化反应，实现N-H氮丙啶的金属自由合成
Raju Silver,Steven P Kelley,Shyam Sathyamoorthi
Raju Silver
Inspired by Bower's intramolecular aziridination reaction, we have developed an intermolecular protocol for the preparation of N-H aziridines from olefins. Our reaction is operationally simple and involves stirring substrate with commercial...
Regioselective iridium(III)-catalyzed C-H cyclization using an acetylene surrogate: direct access to hydroxylated polycyclic phthalazinones [0.03%]
区域选择性铱催化的C-H环化反应使用乙炔衍生物：直接合成含羟基的多环菲唑酮类化合物
Chao Zhang,Hui Zhang,Lin Dong
Chao Zhang
An iridium(III)-catalyzed C-H cyclization between N-arylphthalazinones and 2-chloroacetaldehyde has been developed. This reaction provides efficient access to tetracyclic phthalazine derivatives with broad substrate scope. With the acetylen...
Substrate-controlled divergent synthesis of substituted carbazoles through a cascade reaction of 2-alkenylindoles with α,β-unsaturated ketones [0.03%]
含烯亚胺的α,β-不饱和酮与2-烯基吲哚串联反应合成取代咔唑及其机理研究
Shizhou Yang,Mingliang Wang,Hong Jiang et al.
Shizhou Yang et al.
Substituted carbazoles are valuable N-heterocycles for synthesizing biologically relevant compounds. We established the phosphomolybdic acid/ionic liquid-promoted divergent synthesis of substituted carbazoles, leveraging readily available 2...
Shivam Bhargav,Akash Singh,Ashirwad Divedi et al.
Shivam Bhargav et al.
The transformation of alkynes into nitrogen-containing compounds has emerged as a crucial strategy in modern synthetic chemistry. This review article highlights diverse catalytic approaches for incorporating nitrogen from amines, hydroxylam...
Design of multivalent pharmacological chaperones against Pompe disease via metal-free ligation [0.03%]
无金属连接设计的治疗庞贝氏症的多价药物分子伴侣
Marc Borie-Guichot,Abdelouahd Oukhrib,My Lan Tran et al.
Marc Borie-Guichot et al.
We report herein the design of multivalent pharmacological chaperones (PCs), based on D- and L-deoxynojirimycin (DNJ), to treat Pompe disease (PD), a lysosomal storage disorder caused by mutations in the acid alpha-glucosidase (GAA) enzyme....
Ynones as versatile electrophiles for the divergent synthesis of 4 H-chromenes and 1,4-dihydroquinolines [0.03%]
ynones作为亲电子试剂用于合成4H-香豆素和1,4-二氢喹啉类化合物的发散式策略
Gitanjali Mishra,Potnuru Indu,Gitanjali Muduli et al.
Gitanjali Mishra et al.
An efficient and transition-metal-free strategy for the synthesis of 4H-chromenes and 1,4-dihydroquinolines has been developed using 2-hydroxy/2-amino chalcones and ynones as key reaction partners. The transformation proceeds via a sequenti...