An electrostatically enhanced bifunctional enantioselective thiourea catalyst [0.03%]
一种静电增强的双功能手性硫脲催化剂
Josiah K Nisly,Steven R Kass
Josiah K Nisly
A new bifunctional thiourea featuring a methylated pyridinium ion and a chiral amine is reported. This readily prepared organocatalyst is more active than its analogous 3,5-bis(trifluoromethyl)phenyl substituted thiourea ("Takemoto's cataly...
Correction: Synthesis of thiazolo[4,5- d]pyrimidine derivatives based on purine via solid-phase synthesis [0.03%]
固相合成嘌呤衍生物的文章题目订正：噻唑并[4,5-d]嘧啶的固相合成
Jimin Moon,Hyojin Lee,Jungtae Kim et al.
Jimin Moon et al.
Correction for 'Synthesis of thiazolo[4,5-d]pyrimidine derivatives based on purine via solid-phase synthesis' by Jimin Moon et al., Org. Biomol. Chem., 2025, 23, 7165-7171, https://doi.org/10.1039/D5OB00963D.
Published Erratum
Organic & biomolecular chemistry. 2026 Jan 28. DOI:10.1039/d6ob90007k 2026
Multigram-scale synthesis of an experimental antibiotic, Lolamicin and its intermediate [0.03%]
实验抗生素萝拉霉素及其前体多步全合成
Sanket S Shete,N Sathya Sai Saranya,Kamutam Sairam et al.
Sanket S Shete et al.
Herein, we report a multigram-scale synthesis of the recently discovered antibiotic Lolamicin. To enable rapid analogue generation for lead optimisation, a key intermediate bearing three sites of diversification was designed and prepared on...
A hexadentate Co(III) catalyst enables one-pot quinazolinone synthesis via metal-ligand cooperative alcohol activation [0.03%]
一种六齿配位的Co(III)催化剂通过金属-配体协同活化醇实现一步法合成喹唑酮类化合物
Prashant Kukreti,Tanya Pattnaik,Rahul Chauhan et al.
Prashant Kukreti et al.
Herein, we present the first Co(III)-catalysed efficient metal-ligand cooperative route for the synthesis of quinazolinones via dehydrogenation of primary alcohols. An air-stable phosphine-free Co(III) complex anchored by a hexadentate liga...
One-pot synthesis of α-(OCH2CF3)-substituted pyridines using TFE as both a solvent and a reagent [0.03%]
TFE作为溶剂和试剂的一锅法合成α-(OCH2CF3) substituted吡啶类化合物
Desai Bhavyesh,Arti Ramani,Yash Dhaduk et al.
Desai Bhavyesh et al.
Trifluoroethoxy-substituted pyridines are among the core components of many biologically active scaffolds and have a wide range of applications in fields such as materials science, agrochemicals, and pharmaceuticals. The strategic placement...
Radical-promoted cyclization of 3-allyl-2-arylquinazolinones mediated by silver(I) salts to access SCF3/SCN-enriched dihydroisoquinolino[1,2- b]quinazolinones [0.03%]
含SCF3/SCN的二氢异异喹啉并四氢喹唑林酮类化合物的设计合成及生物活性研究
Vijay Vara,Kishor R Thete,Akram A Khan et al.
Vijay Vara et al.
Herein, we describe an efficient approach for the synthesis of SCF3- and SCN-functionalized polycyclic dihydroisoquinolino[1,2-b]quinazolinones through radical-mediated thio-functionalization of allylic alkenes followed by intramolecular cy...
A three-component 1,3-dipolar cycloaddition of pyrazolone-derived azomethine ylides with succinimides for the construction of novel spiro-pyrazolone-pyrrolizines containing succinimides [0.03%]
用于构建含有琥珀酸亚胺的新型螺-吡唑啉酮-吡咯烷类化合物的吡唑酮衍生物氮杂甲基亚胺基lide与琥珀酸亚胺的三组分1,3-偶极环加成反应
Jianming Xu,Dan Hu,Jian Wang et al.
Jianming Xu et al.
A one-pot, three-component 1,3-dipolar cycloaddition of maleimides with azomethine ylides generated in situ from pyrazolediones and prolines has been developed, and a series of novel pharmaceutically interesting spiro-pyrazolone-pyrrolizine...
Tandem Arbuzov-Perkow reaction: general synthesis of α-substituted vinyl P(V)-compounds [0.03%]
串联arbuzov-perkow反应：合成α-取代烯基p(v)化合物的通用方法
Kuo Zhao,Wenjie Liu,Yu Huang et al.
Kuo Zhao et al.
α-Substituted vinyl P(V)-molecules are important scaffolds with wide applications. Although several synthetic methods have been developed, few of them are equally feasible for the general synthesis of different types of P(V)-structures. He...
Ran Ma,Yuqi You,Yixin Wang et al.
Ran Ma et al.
Herein, we report an efficient electrochemical redox condensation strategy for the construction of diverse 2-substituted benzoxazole derivatives from readily available o-nitrophenols and alcohols in an undivided cell. This electrocatalytic ...
Arylsulfone-driven divergence in base-mediated [3 + 3] benzannulation reactions of aurones: facile synthesis of substituted dibenzofurans [0.03%]
基于苯并菲-none的底物促进的[3+3]芳构化反应中的茋-one驱动的发散性合成含取代基的二苯并呋喃的简便方法
Farooqe Husni P,Alex Andrews P,Rajeev S Menon
Farooqe Husni P
DBU-mediated, facile and divergent [3 + 3] benzannulation reactions of aurones and 1,3-bisnucleophiles afforded substituted dibenzofurans. Nucleophiles possessing at least one arylsulfone group reacted via an elimination pathway whereas die...