Activation of Ferroptosis and NF-κB/NLRP3/MAPK Pathways in Methylmercury-Induced Hepatotoxicity [0.03%]
甲基汞致肝毒性作用中的铁死亡及NF-κB/NLRP3/MAPK通路激活
Yueqing Xie,Hongsen Yu,Yingrong Ye et al.
Yueqing Xie et al.
Methylmercury (MeHg) is a potent hepatotoxin with a complex mechanism of inducing liver injury. Ferroptosis, an iron-dependent form of non-apoptotic cell death, is implicated in various toxicological responses, but its role in MeHg-induced ...
DEHP impairs the oxidative stress response and disrupts trace element and mineral metabolism within the mitochondria of detoxification organs [0.03%]
邻苯二甲酸二乙酯通过损害氧化应激反应和扰乱解毒器官线粒体微量元素及矿物质代谢影响生物体健康
Duygu Aydemir,Gozde Karabulut,Nurhayat Barlas et al.
Duygu Aydemir et al.
Di(2-ethylhexyl) phthalate (DEHP), a widely utilized plasticizer in various consumer products, is classified as an endocrine disruptor and has been implicated in numerous adverse health effects, including oxidative stress, inflammation, and...
Metabolomics reveals that phosphatidylethanolamine can alleviate the toxicity of silica nanoparticles in human lung A549 cells [0.03%]
代谢组学揭示磷脂酰乙醇胺可以通过减轻二氧化硅纳米粒子对人肺癌A549细胞的毒性作用来发挥保护效应
Shuang Chen,Chengzhi Liu,Yifan Yang et al.
Shuang Chen et al.
Silica nanoparticles (SiNPs) are widely utilized in occupational settings where they can cause lung damage through inhalation. The objective of this research was to explore the metabolic markers of SiNPs-induced toxicity on A549 cells by me...
Wnt5a promotes Kupffer cell activation in trichloroethylene-induced immune liver injury [0.03%]
二氯乙烯致免疫性肝损伤时Wnt5a促进枯否细胞活化的作用及机制研究
Lei Gao,Ya-Ni Ding,Peng-Cheng Zhou et al.
Lei Gao et al.
Trichloroethylene (TCE) is a volatile, colorless liquid that is widely used as a chlorinated organic vehicle in industrial production and processing industries. Many workers exposed to trichloroethylene may develop trichloroethylene hyperse...
Perfluorooctane sulfonate causes HK-2 cell injury through ferroptosis and endoplasmic reticulum stress pathways [0.03%]
全氟辛烷磺酸通过铁死亡和内质网应激途径造成HK-2细胞损伤
Shuqi Yan,Haoyan Ma,Yuwan Ren et al.
Shuqi Yan et al.
Perfluorooctane sulfonate (PFOS) is a synthetic persistent organic compound that is widely used in industrial products. Studies have shown that PFOS can accumulate in environment and pose a threat to human health. As the kidney is the main ...
Transcriptome analysis reveals the molecular mechanisms of neonicotinoid acetamiprid in Leydig cells [0.03%]
转录组分析揭示新烟碱类乙酰胺吡虫啉对曲细精管间质细胞的分子机制
Xun Liu,Ce Wang,Yue Ma et al.
Xun Liu et al.
At present, the reproductive toxicology of neonicotinoids has received greater attention, however, its potential mechanisms are still not fully understood. Acetamiprid (ACE) is a new-generation neonicotinoid and has become a ubiquitous cont...
An evaluation of trends for mesothelioma mortality in American women: Addressing the content of a recent Morbidity and Mortality Weekly Report (MMWR) [0.03%]
美国妇女间皮瘤死亡率趋势的评估：回应最近一期《发病率和死亡率周报》(MMWR)的内容
Michael E Stevens,Brett P Tuttle,David W Brew et al.
Michael E Stevens et al.
Mesothelioma is a fatal disease that has historically been associated with exposure to airborne asbestos. Because occupational asbestos exposures dropped dramatically in the late 1960s and early 1970s, far fewer cases of mesothelioma today ...
Citreoviridin induces apoptosis through oxidative damage and inflammatory response in PC-12 cells [0.03%]
链霉素羊毛硫氨酸诱导PC-12细胞凋亡的氧化损伤和炎症反应机制研究
Jing Yang,Jiaojiao Lu,Luoyuan Cao et al.
Jing Yang et al.
Citreoviridin (CIT) is a mycotoxin produced by various fungi. Although CIT has been reported to cause neurotoxicity, the molecular mechanism is poorly understood. Therefore, the aim of this study was to investigate the effects and molecular...
In silico occupational exposure banding framework for data poor compounds in biotechnology [0.03%]
生物技术中数据不足化合物的在体外职业接触带框架
Andrey Massarsky,Ernest S Fung,Veneese Jb Evans et al.
Andrey Massarsky et al.
Occupational exposure limits (OELs) and occupational exposure bands (OEBs) provide quantitative benchmarks for worker health protection. If empirical toxicology data are insufficient to derive an OEL, an OEB is often assigned using partial ...
Effects of bisphenol A, bisphenol S, and tetramethyl bisphenol F on male fertility in Caenorhabditis elegans [0.03%]
双酚A、双酚S和四甲基双酚F对秀丽隐杆线虫雄性生殖力的影响
Cole M Higley,Katelyn D Waligora,Jessica R Clore et al.
Cole M Higley et al.
Research has shown that exposure to bisphenol A (BPA), a widely used plasticizer, can lead to meiotic errors, resulting in poor reproductive cell quality and infertility. Health-related concerns have prompted the search for BPA alternatives...