The soluble epoxide hydrolase inhibitor TPPU alleviates Aβ-mediated neuroinflammatory responses in Drosophila melanogaster and cellular models of alzheimer's disease [0.03%]
可溶性环氧化物水解酶抑制剂TPPU缓解果蝇和阿尔茨海默病细胞模型中的Aβ介导的神经炎症反应
Xiaowen Sun,Hongxiang Liu,Wei Li et al.
Xiaowen Sun et al.
Background: Alzheimer's disease (AD) is a common neurodegenerative disease, and its pathogenesis is closely associated with neuroinflammation. The control of neuroinflammation in AD is the focus of current research. solub...
Intermittent methionine restriction and selenium supplementation protect against inflammation and the development of dermatitis [0.03%]
间歇性蛋氨酸限制和硒补充剂可防止炎症和皮炎的发展
Jason D Plummer,Jay E Johnson
Jason D Plummer
Mesenchymal stem cell-derived exosomal CBLB ameliorates infantile pneumonia progression probably by ubiquitinating MAPK14 [0.03%]
来源于间充质干细胞的携带CBLB蛋白的外泌体通过泛素化MAPK14可能改善婴儿肺炎病情
Fang Guo,Fuxing Song,Zhenjiang Chen et al.
Fang Guo et al.
Background: Infantile pneumonia (IP) is a significant cause of morbidity and mortality in young children. Mesenchymal stem cells (MSCs) have emerged as potential therapeutic agents in pneumonia due to their immunomodulato...
Plasma surrogate markers of neutrophil extracellular traps correlate with disease severity in patients with moderate to severe acute respiratory distress syndrome [0.03%]
中至重度急性呼吸窘迫综合征患者血浆中的中性粒细胞胞外陷阱标志物与疾病严重程度相关
Joni A Aoki,Frederik Denorme,Mark J Cody et al.
Joni A Aoki et al.
Background: Although studies have evaluated the presence of cell-free DNA and neutrophil extracellular traps (NETs) in acute respiratory distress syndrome (ARDS), the kinetics of NET formation during the early ICU admissi...
RhIL-11 reverses liver damage in septic mice by STAT3-mediated M-MDSCs induction modulated by a parallel mTORC1 signaling branch [0.03%]
RhIL-11通过STAT3介导的M-MDSCs诱导（由平行mTORC1信号分支调节）逆转脓毒症小鼠肝损伤
Yuefang Liu,Shujun Gao,Zhanghui Li et al.
Yuefang Liu et al.
Background and objective: Hyperinflammatory response in early stage of sepsis was the key factor leading to multi-organ injury. Therefore, exploring an effective therapy to attenuate or reverse hyperinflammation was the p...
LL-37 and citrullinated-LL-37 modulate IL-17A/F-mediated responses and selectively suppress Lipocalin-2 in bronchial epithelial cells [0.03%]
LL-37及其瓜氨酸化形式调节支气管上皮细胞中IL-17A/F介导的反应并选择性抑制脂联素-2的分泌
Anthony Altieri,Dylan Lloyd,Padmanie Ramotar et al.
Anthony Altieri et al.
Background: Levels of the human cationic antimicrobial host defence peptide LL-37 are enhanced in the lungs during neutrophilic airway inflammation. LL-37 drives Th17 differentiation, and Th17 cells produce IL-17A and IL-...
Exosomes derived from M2 macrophages regulate airway inflammation by modulating epithelial cell proliferation and apoptosis [0.03%]
M2巨噬细胞源性外泌体通过调节上皮细胞增殖和凋亡调控气道炎症反应
Yinying Ren,Mi Zhou,Yuehan Li et al.
Yinying Ren et al.
Background: Asthma is a chronic inflammatory disease characterized by airway remodeling and immune dysregulation. This study aimed to explore the mechanisms by which M2 macrophage-derived exosomes (M2Φ-Exos) regulate air...
Exosomal non-coding RNAs: gatekeepers of inflammation in autoimmune disease [0.03%]
自身免疫性疾病中炎性反应的调控者：细胞外囊泡中的非编码RNA
Mohamed J Saadh,Omer Qutaiba B Allela,Ali Fawzi Al-Hussainy et al.
Mohamed J Saadh et al.
Autoimmune diseases (AIDs) are marked by systemic inflammation and immune dysregulation, yet current therapies often fail to target their underlying causes. Emerging evidence positions exosomal non-coding RNAs (ncRNAs)-including miRNAs, lnc...
Biological mechanisms and therapeutic prospects of interleukin-33 in pathogenesis and treatment of allergic disease [0.03%]
细胞因子白介素-33在过敏性疾病发病机制和治疗中的作用及前景研究进展
Mohammad Chand Jamali,Asma&#x;a H Mohamed,Azfar Jamal et al.
Mohammad Chand Jamali et al.
Allergic diseases significantly impact the quality of life of people around the world. Cytokines play a crucial role in regulating the immune system. Due to their importance in pro-inflammatory mechanisms, cytokines are used to understand p...
Comparison of the inflammatory biomarkers IL- 6, TNF-α, and CRP to predict the effect of nutritional therapy on mortality in medical patients at risk of malnutrition : A secondary analysis of the randomized clinical trial EFFORT [0.03%]
炎性生物标志物白细胞介素-6、肿瘤坏死因子-α和C反应蛋白对医学营养疗法降低营养不良高风险患者死亡率效果预测价值的比较：EFFORT随机临床试验的事后分析结果
Carla Wunderle,Elisabeth Martin,Alma Wittig et al.
Carla Wunderle et al.
Background: Inflammation is a key driver of disease-related malnutrition and patients with high inflammation may not show the same benefits from nutritional therapy as other patients. We compared in an exploratory manner ...