Study of the mechanism of methyltransferase 3 regulation of ferroptosis in allergic rhinitis and promotion of allergic rhinitis in an m6A-dependent mechanism [0.03%]
甲基转移酶3通过m6A依赖机制调节过敏性鼻炎铁死亡的机制研究及促过敏性鼻炎作用
Yunliang Liu,Yuting Huo,Chaofeng Liu et al.
Yunliang Liu et al.
Objective: This study aimed to investigate the regulation of allergic rhinitis (AR) by methyltransferase 3 through an m6A-dependent mechanism, providing a theoretical foundation for its treatment. ...
ADRA2A contributes to airway inflammation and apoptosis in asthma through the ERK signaling in vitro and in vivo [0.03%]
ADRA2A通过ERK信号在哮喘的体内外气道炎症和凋亡中起作用
Fang Zhou,Jia Cai,Lin Chen et al.
Fang Zhou et al.
Non-invasive assessment of activated renal macrophages by imaging of colony-stimulating factor 1 receptor in mouse model with ischemic acute kidney injury [0.03%]
通过成像刺激集落生成细胞因子1受体对缺血急性肾损伤小鼠模型中活化肾巨噬细胞进行无创评估
Sijun Chen,Xinran Zhao,Yanshan Li et al.
Sijun Chen et al.
Background: Emerging evidence suggests that renal inflammation, characterized by the activation of renal macrophages, plays a critical role in the pathogenesis of kidney diseases, including acute kidney injury (AKI). Howe...
Butyrate ameliorates ulcerative colitis through targeting STING-dependent ER stress signaling and limiting CD4+ TRM T cells accumulation [0.03%]
丁酸通过靶向STING依赖的内质网应激信号传导和限制CD4+TRM T细胞积累来改善溃疡性结肠炎
Tengfei Xiao,Jingjing Kang,Chuanxiang Zhao et al.
Tengfei Xiao et al.
This study aimed to investigate the role of butyrate in regulating STING-induced endoplasmic reticulum stress (ERS) and CD4+ tissue-resident memory (TRM) T cells responses during the progression of ulcerative colitis (UC). Our results demon...
Activation of the aryl hydrocarbon receptor relieves acute pancreatitis via the RBX1/HSF1 pathway [0.03%]
芳香烃受体通过RBX1/HSF1通路缓解急性胰腺炎
Yu Fang,Chuanhai Zhang,Jihai Yu et al.
Yu Fang et al.
Ferroptosis-related genes MDM2 and CDKN1A as potential biomarkers for COPD [0.03%]
与COPD相关的铁死亡相关基因MDM2和CDKN1A作为潜在生物标志物
Rui Shi,Lueli Wang,Chunyun Bai et al.
Rui Shi et al.
Objective: Chronic obstructive pulmonary disease (COPD) is characterized by inflammation and an immune response. However, the relationship between ferroptosis and COPD remains unknown. We aim to identify pivotal ferroptos...
Lack of phospho-eIF4E worsens experimental colitis by inhibiting Treg suppressive activity [0.03%]
磷酸化-eIF4E的缺乏通过抑制Treg细胞的抑制活性加重实验性结肠炎
François Santinon,Theodoros Papadopoulos,Meagan-Helen Henderson Berg et al.
François Santinon et al.
Background: Phosphorylation of eIF4E by MNK1/2 modulates protein synthesis by controlling the translation of specific mRNAs. Immune cells use the MNK1/2-eIF4E axis to adapt their gene expression in response to environment...
Rapid autofluorescence flow cytometric analysis of agonist-induced neutrophil and eosinophil polarization reveals novel insights into 5-oxo-ETE-mediated granulocyte activation [0.03%]
激动剂诱导的中性粒细胞和嗜酸性粒细胞极化快速自动荧光流式分析揭示了5-氧-EET介导的颗粒细胞活化的全新见解
Anuruddika J Fernando,Fiona Rossi,Destiny Docherty et al.
Anuruddika J Fernando et al.
Minimizing unintended granulocyte activation while measuring functional responsiveness is essential, as the use of external probes, antibodies, or fluorescent dyes can potentially alter cellular responsiveness. To address this, we employed ...
Correction: The critical role of methylenetetrahydrofolate dehydrogenases in immune regulation and auto-immunity [0.03%]
关于甲烯四氢叶酸脱氢酶在免疫调节和自身免疫中的关键作用的更正通知
Peter Bunyard,Marina Makrecka-Kuka,Laura McMillan
Peter Bunyard
The critical role of methylenetetrahydrofolate dehydrogenases in immune regulation and auto-immunity [0.03%]
亚甲基四氢叶酸脱氢酶在免疫调节和自身免疫中的关键作用
Peter Bunyard,Marina Makrecka-Kuka
Peter Bunyard
1-carbon (1 C) metabolism is a key process required for nucleotide synthesis in activated lymphocytes and other immune-regulatory mechanisms. Commonly used and well-established drugs for the treatment of inflammatory disorders such as metho...