The metabolic intersection between immunosenescence and neuroinflammation in amyotrophic lateral sclerosis [0.03%]
免疫衰老和神经炎症在肌萎缩侧索硬化症中的代谢交汇点
Victoria S K Tsang,Andrea Malaspina,Sian M Henson
Victoria S K Tsang
Long-term risk of de novo malignancy with tumor necrosis factor alpha (TNF) inhibitor immunosuppression: a multicenter, retrospective cohort study [0.03%]
肿瘤坏死因子α抑制剂免疫抑制治疗后新发恶性肿瘤的长期风险：一项多中心回顾性队列研究
Conor B Driscoll,Jordan M Rich,Christopher Yang et al.
Conor B Driscoll et al.
Background: Tumor necrosis factor-alpha (TNF) is an inflammatory cytokine implicated in the development of many chronic inflammatory diseases and TNF-α inhibitors (TNF-I) are frequently prescribed as treatment. Their mal...
Hydroxychloroquine reduces metastatic tumor burden in pancreatic adenocarcinoma through myeloperoxidase inhibition [0.03%]
羟氯喹通过抑制髓过氧化物酶减少胰腺癌转移肿瘤负荷
Britney Niemann,Pavan Rao,Quinn Hopen et al.
Britney Niemann et al.
Background: Metastatic pancreatic adenocarcinoma has a 5-year survival of only 3%. Neutrophil extracellular traps are formed when neutrophils expel their intracellular contents and have been intricately linked to metastas...
C-reactive protein modulates lipid mediators in a pro-inflammatory direction [0.03%]
C反应蛋白以促炎方向调节脂质介质
Makoto Kurano,Kazuhisa Tsukamoto,Hideaki Isago et al.
Makoto Kurano et al.
Background: C-reactive protein (CRP) is a risk factor for atherosclerosis. Although inflammation may confound this association, CRP itself has been hypothesized to possess both pro-atherosclerotic and pro-inflammatory pro...
Associations of leucocyte subtypes and platelet parameters with kidney cancer risk in the UK Biobank cohort [0.03%]
英国生物银行队列中白细胞亚型和血小板参数与肾癌风险的关系
Sofia Christakoudi,Konstantinos K Tsilidis,Marc J Gunter et al.
Sofia Christakoudi et al.
Background: Kidney cancer is related to obesity and inflammation and platelets are involved in thrombo-inflammation, but the prospective associations of individual leucocyte subtypes and platelet parameters with kidney ca...
NAD + metabolism and function in innate and adaptive immune cells [0.03%]
天然免疫和适应性免疫细胞中的烟酰胺腺嘌呤二核苷酸代谢与功能
Rebecca Mann,Victoria Stavrou,Sarah Dimeloe
Rebecca Mann
Nicotinamide adenine dinucleotide (NAD+) plays a central role in cellular metabolism and energy production, supporting many biological processes. Recent studies highlight the significance of NAD + in regulation of immune cell function, with...
Unveiling the anti-inflammatory potential of RF16, an interleukin 8-derived therapeutic peptide in macrophages [0.03%]
一种衍生的白细胞介素8肽类药物RF16在巨噬细胞中的抗炎潜力研究
Chun-Chun Chang,Hsuan-Yu Tu,Shih-Yi Peng et al.
Chun-Chun Chang et al.
Background: Interleukin 8 (IL-8, also known as CXCL-8) regulates inflammation and breast cancer formation by activating its cognate receptor CXCR1/2. In our previous study, a RF16 peptide, derived from the IL-8 binding re...
Verteporfin attenuates NLRP3 inflammasome activation to alleviate gout arthritis flares [0.03%]
verteporfin通过抑制NLRP3炎性小体活化来缓解痛风急性发作
Daniel C Shippy,Tyler K Ulland
Daniel C Shippy
Background: Gout arthritis (GA) is an inflammatory disorder characterized by the deposition of monosodium urate (MSU) crystals within synovial joints due to increased urate concentrations in the body. The NLRP3 inflammaso...
Curcumin and omega-3 ameliorate experimental osteoarthritis progression in terms of joint pain and mitochondrial dysfunction [0.03%]
姜黄素和ω-3脂肪酸通过减轻关节疼痛和线粒体功能障碍缓解实验性骨关节炎进展
JooYeon Jhun,Donghwan Lee,Hyun Sik Na et al.
JooYeon Jhun et al.
Background: Osteoarthritis (OA), a chronic degenerative disorder, induces pain, joint inflammation, and destruction of the articular cartilage matrix. Curcumin and omega-3 have been used as dietary supplements for OA due ...
The potential role of 1,25(OH)2D3 (Active vitamin D3) in modulating macrophage function; implications for chronic obstructive pulmonary disease (COPD) [0.03%]
活性维生素D3（1,25(OH)₂D₃）在调节巨噬细胞功能中的潜在作用；对慢性阻塞性肺病的影响
Hy Thai,Rei Hassanen,Trevor Whittall et al.
Hy Thai et al.
Macrophages play an important role in tissue homeostasis, inflammation, and repair, displaying remarkable plasticity by polarising towards pro-inflammatory M1 or anti-inflammatory M2 phenotypes. In chronic obstructive pulmonary disease (COP...