Simplified flow cytometric quantification of human neutrophil extracellular traps (NETs) [0.03%]
人中性粒细胞胞外陷阱(NETs)的简化流式细胞术量化方法
G Rinaldi,K K W Cheng,C McCann et al.
G Rinaldi et al.
Several cellular pathways lead to the formation of neutrophil extracellular traps (NETs), a form of cell death (NETosis), distinct from apoptotic and necrotic cell death. Surprisingly, there remains a paucity of methods enabling efficient q...
Montelukast suppresses NLRP3 inflammasome activation as a potential prophylactic agent against gout arthritis flares [0.03%]
蒙赖卢卡斯通过抑制NLRP3炎性小体激活而成为预防痛风关节炎发作的潜在药物
Daniel C Shippy,Abigail H Evered,Tyler K Ulland
Daniel C Shippy
Background: Gout arthritis (GA) flares are unexpected bouts of heat, swelling, and redness resulting in excruciating pain caused by monosodium urate (MSU) crystal deposition in the synovial joints. GA flare symptoms occur...
Bromodomain-containing protein 4 in inflammatory diseases: molecular mechanisms and therapeutic potential [0.03%]
溴结构域蛋白4在炎症性疾病中的分子机制和治疗潜力
Rachele Frascatani,Irene Marafini,Marco Colella et al.
Rachele Frascatani et al.
Diagnostic and prognostic value of LINC00278 in patients with severe pneumonia and its regulatory role [0.03%]
LINC00278在重症肺炎患者中的诊断、预后价值及调控作用
Yanshan Liu,Cuihong Zhou,Zhipeng Guo et al.
Yanshan Liu et al.
Sepsis induces long-term reprogramming of human HSPCs and drives myeloid dysregulation in sepsis survivors [0.03%]
脓毒症会诱导人类造血干细胞的长期再编程并驱动脓毒症幸存者的髓系失调
Marco De Zuani,Petra Lázničková,Marcela Hortová Kohoutková et al.
Marco De Zuani et al.
Background: Sepsis is a life-threatening condition characterised by an overwhelming immune response and high fatality. While most research has focused on its acute phase, many sepsis survivors remain immunologically weake...
Bradykinin reduces wound healing in human umbilical vein endothelial cells via downregulation of vascular endothelial growth factor A [0.03%]
补体C激肽通过下调血管内皮生长因子A来抑制人脐静脉内皮细胞的伤口愈合
Nevena Dimitrova,Angelina Gierke,Raphael Möhrle et al.
Nevena Dimitrova et al.
USP8 inhibits cigarette smoke extract combined with LPS-induced inflammatory response and ER stress by regulating the ABCB1-mediated MAPK signaling pathway in human bronchial epithelial cells [0.03%]
USP8通过调节ABCB1介导的MAPK信号通路抑制香烟冷凝物与LPS诱导的人支气管上皮细胞炎症反应及内质网应激作用
Meng Wang,Weipeng Song,Xiaoming Liu et al.
Meng Wang et al.
Background: Chronic obstructive pulmonary disease (COPD) is a significant global cause of morbidity and mortality and is characterized by airway remodeling, inflammation, and endoplasmic reticulum stress (ER stress) progr...
Immunomodulatory effects of Purion processed human amniotic membrane allografts in vitro [0.03%]
体外胎盘膜的免疫调节作用
Sarah E Moreno,Joseph Mikulin,Michelle Massee et al.
Sarah E Moreno et al.
Background: The immune system plays a pivotal role in progressing an injury through the healing cascade. However, comorbidities often lead to dysregulation of this response and are implicated in wound chronicity or stalli...
Erianin regulates allergic rhinitis via KAT2A-mediated histone succinylation [0.03%]
埃里安因通过KAT2A介导的组蛋白琥珀酰化调节过敏性鼻炎
Hai-Ying Wang,Chang-Yang Wang,Qing-Fu Bao et al.
Hai-Ying Wang et al.
Study of the mechanism of methyltransferase 3 regulation of ferroptosis in allergic rhinitis and promotion of allergic rhinitis in an m6A-dependent mechanism [0.03%]
甲基转移酶3通过m6A依赖机制调节过敏性鼻炎铁死亡的机制研究及促过敏性鼻炎作用
Yunliang Liu,Yuting Huo,Chaofeng Liu et al.
Yunliang Liu et al.
Objective: This study aimed to investigate the regulation of allergic rhinitis (AR) by methyltransferase 3 through an m6A-dependent mechanism, providing a theoretical foundation for its treatment. ...