Glutaminase activity maintains NK cell cytotoxicity through metabolic regulation of effector function [0.03%]
谷氨酰胺酶活性通过代谢调节效应功能来维持自然杀伤细胞的细胞毒性
M Jedlička,T Feglarová,V Švubová et al.
M Jedlička et al.
Background: Natural killer (NK) cells are responsible for monitoring and eliminating malignant or virus-infected cells. To become activated, NK cells must upregulate oxidative phosphorylation and glycolysis to meet the hi...
Effect of heme oxygenase-1 on the expression of interferon-stimulated genes [0.03%]
血红素加氧酶-1对I型干扰素诱导基因表达的影响
Patryk Chudy,Katarzyna Bednarczyk,Eryk Chatian et al.
Patryk Chudy et al.
Heme oxygenase-1 (HO1, Hmox1) degrades excess heme and is considered an anti-oxidative and anti-inflammatory enzyme. Our previous studies in Hmox1 knockout mice revealed the induction of interferon-stimulated genes (ISGs) in all cell types ...
Chenlu Zhu,Jing Lu,Jun Zhang et al.
Chenlu Zhu et al.
Purpose of review: To summarize the current understanding of the pathogenesis of cerebral atherosclerosis to provide a basis for developing effective treatments and exploring future research directions for clinical applic...
Baicalein inhibits mycobacterium tuberculosis-induced macrophage M1 polarization depending on the regulation of YY1/RAB10/TLR4 pathway [0.03%]
黄芩素通过调节YY1/RAB10/TLR4信号通路抑制巨噬细胞M1极化作用于抗结核感染
Qing Zhou,Shuanghua Chen,Linfei Shu et al.
Qing Zhou et al.
Background: Baicalein (Bai) has been found to alleviate the progression of tuberculosis (TB) by inhibiting mycobacterium tuberculosis (M.tb)-induced macrophage pyroptosis, so it may be used as an adjuvant treatment for TB...
Immunological response and tissue loss in a rodent model of chronic traumatic brain injury treated with resolvin [0.03%]
慢性创伤性脑损伤啮齿类模型中神经炎症反应和组织损失以及脂氧素A4促进创伤后恢复的作用研究
Olivia Kiwanuka,Julie Cheung,Anders Hånell et al.
Olivia Kiwanuka et al.
Background: Traumatic brain injury (TBI) triggers neuroinflammation both acutely and chronically, the latter which might be involved in neurodegenerative disorders. Resolvins are neuroinflammatory modulators, hypothesized...
Immunological response and tissue loss in a rodent model of chronic traumatic brain injury treated with resolvin [0.03%]
resolution治疗慢性创伤性脑损伤啮齿类动物模型的免疫反应及组织损伤状况的研究
Olivia Kiwanuka,Julie Cheung,Anders Hånell et al.
Olivia Kiwanuka et al.
Background: Traumatic brain injury (TBI) triggers neuroinflammation both acutely and chronically, the latter which might be involved in neurodegenerative disorders. Resolvins are neuroinflammatory modulators, hypothesized...
Loss of tuberous sclerosis complex 2 confers inflammation via dysregulation of nuclear factor kappa-light-chain-enhancer of activated B cells [0.03%]
结节性硬化症复合体2失活通过调控核因子κ-光链激活的B细胞导致炎症反应失调
Darius K McPhail,Mohammad A M Alzahrani,Katie R Martin et al.
Darius K McPhail et al.
Background: Aberrant activation of mTORC1 is clearly defined in TSC and causes uncontrolled cell growth. While mTORC1 inhibitors show efficacy in stabilising tumour growth in patients with TSC, they are not fully curative...
Beyond energy: how TCA cycle-derived metabolites regulate gene expression and inflammation in the nucleus [0.03%]
超越能量：TCA循环衍生代谢物如何在细胞核内调控基因表达和炎症反应
Jaiya Randhawa,Eva M Pålsson-McDermott
Jaiya Randhawa
Immune cells can rewire their metabolism in response to various stimuli. Crosstalk between the nucleus and mitochondria allows for tight regulation of this metabolic reprogramming. Research has emerged showing several TCA cycle-derived meta...
In-depth investigation of the mechanism in rats with alcoholic acute pancreatitis via DNA methylation, intestinal flora, and fecal metabolomics [0.03%]
基于DNA甲基化、肠道菌群及粪便代谢组学的酒精性急性胰腺炎大鼠机制研究
Haicheng Dong,Weixing Ying,Shifeng Zhu
Haicheng Dong
Background: Alcohol consumption is the main cause of acute pancreatitis (AP). Alcohol combined with cerulein (CI) exerts direct damage to pancreas, with its mechanism undefined. ...
Identification of neutrophil extracellular traps-related genes for the diagnosis of acute myocardial infarction based on bioinformatics and experimental verification [0.03%]
基于生物信息学和实验验证识别用于急性心肌梗死诊断的中性粒细胞胞外诱捕网相关基因
Hua-Jing Yuan,Yi-Ding Yu,Wen-Wen Liu et al.
Hua-Jing Yuan et al.