The anti-inflammatory properties of vinpocetine mediates its therapeutic potential in management of atherosclerosis [0.03%]
长春西汀的抗炎特性可介导其在动脉粥样硬化治疗中的潜力
Abdullah A Alshehri,Hayder M Al-Kuraishy,Ali I Al-Gareeb et al.
Abdullah A Alshehri et al.
Atherosclerosis (AS) formation is enhanced by different mechanisms including cytokine generation, vascular smooth muscle cell proliferation, and migration. One of the recent treatments towards endothelial dysfunction and AS is Vinpocetine (...
Cinnamaldehyde inhibits the NLRP3 inflammasome by preserving mitochondrial integrity and augmenting autophagy in Shigella sonnei-infected macrophages [0.03%]
肉桂醛通过保护线粒体并促进自噬抑制宋内志贺菌感染的巨噬细胞中的NLRP3炎性小体
Kuo-Feng Hua,Yu-Bei Lin,Hsiao-Wen Chiu et al.
Kuo-Feng Hua et al.
Background: Worldwide, more than 125 million people are infected with Shigella each year and develop shigellosis. In our previous study, we provided evidence that Shigella sonnei infection triggers activation of the NACHT...
Lipopolysaccharide pretreatment increases the sensitivity of the TRPV1 channel and promotes an anti-inflammatory phenotype of capsaicin-activated macrophages [0.03%]
脂多糖预处理可增强瞬时受体电位香草素亚型1通道的敏感性并促进辣椒素激活的巨噬细胞向抗炎表型转化
Daniel Vašek,Natálie Fikarová,Vendula Nagy Marková et al.
Daniel Vašek et al.
Background: The transient receptor potential vanilloid 1 (TRPV1) is well-established in neuronal function, yet its role in immune reactions remains enigmatic. The conflicting data on its inflammatory role, suggesting both...
Histone H3 posttranslational modified enzymes defined neutrophil plasticity and their vulnerability to IL-10 in the course of the inflammation [0.03%]
组蛋白H3翻译后修饰酶定义了中性粒细胞的可塑性和其在炎症过程中的易感性IL-10性
Paweł Piatek,Magdalena Namiecinska,Natalia Lewkowicz et al.
Paweł Piatek et al.
Background: Neutrophils are a heterogeneous population capable of antimicrobial functions associated with pre-activation/activation and tissue regeneration. The specific polarisation of immune cells is mediated by the mod...
Coarse particulate matter (PM10) induce an inflammatory response through the NLRP3 activation [0.03%]
粗颗粒物(PM10)通过NLRP3激活诱导炎症反应
Damariz Marín-Palma,Jorge H Tabares-Guevara,Natalia Taborda et al.
Damariz Marín-Palma et al.
Introduction: PM exposure can induce inflammatory and oxidative responses; however, differences in these adverse effects have been reported depending on the chemical composition and size. Moreover, inflammatory mechanisms...
Unconventional activation of PRKDC by TNF-α: deciphering its crucial role in Th1-mediated inflammation beyond DNA repair as part of the DNA-PK complex [0.03%]
TNF-α非传统激活PRKDC的机制及其在Th1介导炎症反应中的作用：超越DNA修复的DNA-PK复合物的重要成员
Mohamed A Ghonim,Jihang Ju,Kusma Pyakurel et al.
Mohamed A Ghonim et al.
Background: The DNA-dependent protein kinase (DNA-PK) complex comprises a catalytic (PRKDC) and two requisite DNA-binding (Ku70/Ku80) subunits. The role of the complex in repairing double-stranded DNA breaks (DSBs) is est...
Fine particulate matter aggravates smoking induced lung injury via NLRP3/caspase-1 pathway in COPD [0.03%]
细颗粒物通过NLRP3/ caspase-1信号途径加重慢性阻塞性肺疾病患者的吸烟性肺损伤作用
Chiwook Chung,Suk Young Park,Jin-Young Huh et al.
Chiwook Chung et al.
Background: Exposure to noxious particles, including cigarette smoke and fine particulate matter (PM2.5), is a risk factor for chronic obstructive pulmonary disease (COPD) and promotes inflammation and cell death in the l...
Crtc1 deficiency protects against sepsis-associated acute lung injury through activating akt signaling pathway [0.03%]
Crtc1缺陷通过激活Akt信号通路对抗内毒素诱导的急性肺损伤作用
Meng Chen,Jian Lv,Ningning Guo et al.
Meng Chen et al.
Background: Interplay between systemic inflammation and programmed cell death contributes to the pathogenesis of acute lung injury (ALI). cAMP-regulated transcriptional coactivator 1 (CRTC1) has been involved in the norma...
Mitochondria protective and anti-apoptotic effects of peripheral benzodiazepine receptor and its ligands on the treatment of asthma in vitro and vivo [0.03%]
苯二氮卓受体及其配体对哮喘的线粒体保护和抗凋亡效应：体内、外研究
Yurui Liu,Zhengze Zhang,Yuewen He et al.
Yurui Liu et al.
Background: Asthma is a prevalent respiratory inflammatory disease. Abnormal apoptosis of bronchial epithelial cells is one of the major factors in the progression of asthma. Peripheral benzodiazepine receptors are highly...
EGFR of platelet regulates macrophage activation and bacterial phagocytosis function [0.03%]
血小板中的表皮生长因子受体调节巨噬细胞活化和细菌吞噬功能
Shuhua Luo,Riping Xu,Pengyun Xie et al.
Shuhua Luo et al.
Background: Beyond their crucial role in hemostasis, platelets possess the ability to regulate inflammation and combat infections through various mechanisms. Stringent control of macrophage activation is essential during ...