In vitro effects of the tyrosine kinase inhibitor, masitinib mesylate, on canine hemangiosarcoma cell lines [0.03%]
酪氨酸激酶抑制剂masitinib甲磺酸盐对犬源性血管肉瘤细胞系的体外作用效果研究
S E Lyles,R J Milner,K Kow et al.
S E Lyles et al.
This study evaluated the in vitro activity of masitinib mesylate against canine hemangiosarcoma (HSA) cell lines after treatment with increasing concentrations of masitinib mesylate (0.01-100 µM) for 24, 48 and 72 h. Results indicated that...
Evaluation of bone marrow aspirates from multiple sites for staging of canine lymphoma and mast cell tumours [0.03%]
评估骨髓抽吸物取样部位对犬淋巴瘤和肥大细胞瘤分期的影响
O A Aubry,E A Spangler,S E Schleis et al.
O A Aubry et al.
This prospective study evaluated the utility of bone marrow aspirates (BMAs) obtained from multiple sites for staging of canine lymphoma (LSA) and mast cell tumours (MCTs). Forty dogs (LSA, n = 24; MCTs, n = 16) were enrolled, but only 33 (...
Evaluation of a 15-week CHOP protocol for the treatment of canine multicentric lymphoma [0.03%]
评估治疗犬多中心淋巴瘤的15周CHOP方案的效果
J H Burton,E Garrett-Mayer,D H Thamm
J H Burton
Dose intense CHOP protocols have been shown to improve outcome for people with non-Hodgkin's lymphoma, but evaluation of dose intense CHOP protocols for canine lymphoma is currently limited. The hypothesis of this retrospective study was th...
S Y Oh,H H Ryu,D Y Yoo et al.
S Y Oh et al.
The expression of the transcription factor forkhead box P3 (FOXP3) was examined in 62 canine mammary gland tumours via immunohistochemical analysis and association with the known expression of the oestrogen receptor-alpha (ERα), progestero...
Liposomal clodronate treatment for tumour macrophage depletion in dogs with soft-tissue sarcoma [0.03%]
用于患有软组织肉瘤的狗的肿瘤巨噬细胞耗竭的脂质体氯膦酸盐治疗
A M Guth,S D Hafeman,R E Elmslie et al.
A M Guth et al.
Increased numbers of tumour-associated macrophages correlate with rapid tumour growth and metastasis in tumours. Thus, macrophage depletion has potential as a novel cancer therapy and positive responses have been reported in rodent tumour m...
Prognostic value of tumour-associated macrophages in canine mammary tumours [0.03%]
肿瘤相关巨噬细胞在犬乳腺肿瘤中的预后价值
T Raposo,H Gregório,I Pires et al.
T Raposo et al.
Tumour-associated macrophages (TAMs) have already been associated in human breast cancer to a poor prognosis. As a part of a tumoural microenvironment, TAMs have an important contribution influencing neoplastic progression. Hitherto, in can...
The usefulness of immunohistochemistry to differentiate between nasal carcinoma and lymphoma in cats: 140 cases (1986-2000) [0.03%]
免疫组织化学鉴别猫鼻腔淋巴瘤和鼻腔癌的临床意义（1986-2000年回顾研究140例）
K Nagata,M Lamb,M H Goldschmidt et al.
K Nagata et al.
A retrospective evaluation of 232 feline nasal biopsies initially diagnosed as either carcinoma or lymphoma was performed by two pathologists. One or both pathologists disagreed with the original diagnosis in 15 cases (7%), 14 of which had ...
Intraperitoneal antineoplastic drug delivery: experience with a cyclophosphamide, vincristine and prednisolone protocol in cats with malignant lymphoma [0.03%]
腹腔内抗癌药物给药：使用环磷酰胺，长春新碱和泼尼松龙方案治疗恶性淋巴瘤猫的经验
E Teske,A J van Lankveld,G R Rutteman
E Teske
In this retrospective study, the efficacy and safety were examined for an intraperitoneal chemotherapy protocol-cyclophosphamide, vincristine and prednisolone (IP-COP) in 26 cats with malignant lymphoma. Certainly in cats fiercely resisting...
L Aresu,A Aricò,S Comazzi et al.
L Aresu et al.
Vascular endothelial growth factor (VEGF) and metalloproteinase (MMP) 2 and 9 are useful biomarkers in human lymphoma. During cancerogenesis, transforming growth factor beta (TGF-β) stimulates VEGF and MMPs production. VEGF and TGF-β plas...
Phosphotyrosine enrichment identifies focal adhesion kinase and other tyrosine kinases for targeting in canine hemangiosarcoma [0.03%]
磷酸酪氨酸富集鉴定出犬源性血管肉瘤中的黏着斑激酶及其他酪氨酸激酶靶点
K Marley,C S Maier,S C Helfand
K Marley
Canine hemangiosarcoma (HSA) is an endothelial cell malignancy driven, in part, by activating mutations in receptor and non-receptor tyrosine kinases. Proteomics, Western blots and a tyrosine kinase inhibitor were used to elucidate activati...