Toxicity of Cytarabine Intravenous Constant Rate Infusion in Cats With Lymphoma [0.03%]
胞嘧啶阿糖胞苷在猫淋巴瘤静脉持续滴注的毒性研究
Rachel Hanford,Katherine A Skorupski,Robert B Rebhun et al.
Rachel Hanford et al.
Cytarabine intravenous constant rate infusion (IV CRI) toxicity in cats with lymphoma has not been well documented. We aimed to assess toxicities following cytarabine IV CRI as a single-agent or within a multiagent protocol in cats with lym...
Immunohistochemical Characterisation of Mismatch Repair Proteins in Feline Cancers: A Pilot Study Using Validated Cross-Reactive Antibodies [0.03%]
利用交叉反应抗体验证的免疫组化法检测猫科动物肿瘤中错配修复蛋白的表达：一项初步研究
Shoma Nishibori,Masashi Sakurai,Yumiko Kagawa et al.
Shoma Nishibori et al.
DNA mismatch repair (MMR) deficiency is a clinically important biomarker in human oncology, yet its relevance in feline neoplasia remains poorly understood due to limited characterisation and the absence of validated reagents. In this study...
Clinical Outcome and Histopathologic Assessment of Canine Perivulvar Mast Cell Tumours [0.03%]
犬阴道周围 mast细胞瘤的临床预后和组织病理学评估
Madison R Ahrens,Sarah M Corner,Alison Masyr
Madison R Ahrens
Anatomic location is a known prognostic factor for canine mast cell tumours (MCTs). Previous publications have reported conflicting results about the clinical significance of MCT location in the inguinal and perineal regions and male genita...
Clinical Outcome and Histopathologic Assessment of Canine Perivulvar Mast Cell Tumours [0.03%]
犬阴唇周围 mast细胞肿瘤的临床预后和病理学评估
Madison R Ahrens,Sarah M Corner,Alison Masyr
Madison R Ahrens
Anatomic location is a known prognostic factor for canine mast cell tumours (MCTs). Previous publications have reported conflicting results about the clinical significance of MCT location in the inguinal and perineal regions and male genita...
Fluvastatin Plus Dipyridamole Suppresses Canine Hemangiosarcoma Growth in Patient-Derived Xenograft Models Through Lactate Dehydrogenase-Associated Cholesterol/Lipid Metabolism [0.03%]
氟伐他汀联合双嘧达莫通过乳酸脱氢酶相关的胆固醇/脂质代谢抑制犬患者的移植瘤模型中血管肉瘤的生长
Tamami Suzuki,Suzune Tanaka,Keika Kishimoto et al.
Tamami Suzuki et al.
Tumour cells commonly exhibit aerobic glycolysis and produce lactate despite oxygen availability. Lactate dehydrogenase (LDH) catalyses pyruvate-lactate interconversion and regulates intracellular lactate levels. Endothelial cells also depe...
CT-Based Radiomic Features Predict Cervical Lymph Node Metastasis in Dogs With Oral Malignancy: A Machine Learning Study Using Leave-One-Patient-Out Cross-Validation [0.03%]
基于CT的影像组学特征预测口腔恶性肿瘤犬头颈部淋巴结转移：一种利用交叉验证的机器学习方法
Christopher J Pinard,Andrew Lagree,Ryan Appleby et al.
Christopher J Pinard et al.
Accurate preoperative identification of cervical lymph node (LN) metastasis is essential for staging and treatment planning in dogs with oral malignancy, yet conventional imaging offers limited diagnostic sensitivity. This retrospective stu...
Safety and Feasibility of Infusing Ex Vivo Expanded Allogeneic Canine Natural Killer Cells for the Treatment of Metastatic Solid Tumours [0.03%]
体外扩增的同种异体犬天然杀伤细胞治疗转移性实体瘤的安全性和可行性研究
Allison M Weisnicht,Fernanda Szewc,Monica Moonkyung Cho et al.
Allison M Weisnicht et al.
Companion canines need advances in therapeutic options for solid tumour malignancies. Natural killer (NK) cell infusions offer a promising treatment modality in canines with solid tumours. Autologous natural killer products are limited by d...
Enhancing EGFR Inhibition: Monensin and Erlotinib Synergize to Eliminate Cancer Stem Cells in Canine Mammary Tumours [0.03%]
增强EGFR抑制作用：单霉素和厄洛替尼协同消除犬乳癌干细胞
Tian Fang,Mengxing Zhang,Chang Ma et al.
Tian Fang et al.
Canine mammary tumours (CMTs) and human breast cancer (HBC) share highly similar pathological characteristics. Cancer stem cells (CSCs) are critical to breast cancer invasion, metastasis, drug resistance, and recurrence. The experiment util...
Sentinel Lymph Node Mapping Identifies Variable Cervical Drainage and Metastatic Nodes Outside Traditional Sampling Sites in Canine Oromaxillofacial Tumours [0.03%]
哨兵淋巴结显像可识别犬口腔颌面部肿瘤变异性颈淋巴引流及传统取样部位外的转移淋巴结
Emilia Chrostek,Jessica Lawrence,Boaz Arzi et al.
Emilia Chrostek et al.
Sentinel lymph node mapping (SLNM) has emerged as a key technique to guide decisions regarding nodal extirpation in dogs with oromaxillofacial tumours. The primary aims of this retrospective study were to describe the clinical utility of in...
Comparison of Aerosolised and Traditional Tumour Margin Inking: A Prospective Blinded Histopathological Review in Canine Skin Tumours [0.03%]
犬皮肤肿瘤气溶胶和传统涂色组织学分析的比较研究
Kaida L Wouters,Sam R Snelling,John M Morton et al.
Kaida L Wouters et al.
Inking of canine skin tumours facilitates histopathological margin assessment. While traditional dab application is standard practice, aerosolised (spray) application may offer practical advantages. The objective of this study was to determ...