Sequence Diversity and Expression Profiles of T Cell Receptor Beta Chain Constant Genes TRBC1 and TRBC2 in Canine Lymphoid Tumour Cell Lines and Normal Lymphocytes [0.03%]
犬淋巴瘤细胞系和正常淋巴细胞中T细胞受体β链恒定区基因TRBC1和TRBC2的序列多样性及表达特征分析
Marek Pieczka,Leszek Moniakowski,Aleksandra Studzińska et al.
Marek Pieczka et al.
The subtle sequence diversity and mutually exclusive expression patterns of T cell receptor beta chain constant genes, TRBC1 and TRBC2, in mature human T cells, provide the basis for immune-targeting strategies designed to eliminate clonall...
Machine Learning-Based Risk Prediction for Feline Mammary Tumours: A Comprehensive Epidemiological Analysis Using Multi-Model Ensemble Approach [0.03%]
基于机器学习的猫乳腺肿瘤风险预测：使用多模型集成方法的全面流行病学分析
Kübra Nur Çalı Özçelik,Salih Taha Alperen Özçelik,Sema Timurkaan
Kübra Nur Çalı Özçelik
Feline mammary tumours represent the third most common malignancy in cats, with limited evidence-based tools available for risk assessment and screening guidance. Traditional veterinary approaches rely on subjective clinical judgement, lack...
Development and Testing of an Owner-Reported Outcome Measure of Clinical Signs and Quality of Life in Dogs Treated With Chemotherapy [0.03%]
从接受化疗的狗身上开发并测试的一种临床症状和生活质量的所有者报告结果指标
Jenny Harris,Katie Sutton,Quentin Fournier et al.
Jenny Harris et al.
Cancer is a leading cause of mortality in older dogs. Despite the prevalence of chemotherapy in canine oncology, a good understanding of owners' observations of side effects and clinical signs in real time is still lacking. Owners' percepti...
Phase 1 Dose Escalation of Single-Agent Mechlorethamine in Dogs With Lymphoma [0.03%]
单剂氮芥治疗淋巴瘤犬的I期爬坡试验
Laura E Chadsey,Paul R Hess,Joanne L Intile
Laura E Chadsey
Mechlorethamine is commonly prescribed to dogs at 3 mg/m2. The minimal toxicity observed indicates that higher doses of mechlorethamine are likely tolerable. The primary objective of this study was to determine the maximally tolerated dose ...
Polarisation-Sensitive Optical Coherence Tomography for Surgical Margin Evaluation and Diagnosis of Excised Canine Cutaneous and Subcutaneous Tumours [0.03%]
用于切除犬皮肤和皮下肿瘤的手术边缘评估和诊断的偏振敏感光学相干断层扫描技术
Christina E Orona,Ryan Jennings,Julianna DiMichele et al.
Christina E Orona et al.
Intraoperative surgical margin evaluation is not routine in veterinary medicine. Polarisation-sensitive optical coherence tomography (PS-OCT) is a variant of spectral domain optical coherence tomography (SD-OCT) that can provide real-time c...
Utility of Cytochemical and Flow Cytometry Detection of Alkaline Phosphatase for Differential Diagnosis of CD34+ Acute Leukaemia in Canines [0.03%]
犬CD34+急性白血病鉴别诊断中细胞化学和流式细胞仪检测碱性磷酸酶的意义
Megan Aalto,Janna Yoshimoto,Jillian Nolan et al.
Megan Aalto et al.
Alkaline phosphatase (ALP) enzymatic activity has been proposed as a marker for distinguishing canine acute leukaemia (AL) subtypes (i.e., myeloid vs. lymphoid). However, ALP enzymatic activity has not been fully evaluated in CD34+ AL. Dete...
Performance of Frozen Section Histopathology, Imprint Cytology and Fine-Needle Aspirates for Detecting Canine Metastatic Mast Cell Tumour [0.03%]
冰冻切片病理学、印片细胞学及细针抽吸检测犬转移性肥大细胞瘤的效果
Alejandro Alvarez-Sanchez,Katy L Townsend,Elena Gorman et al.
Alejandro Alvarez-Sanchez et al.
Intra-operative staging of canine mast cell tumour (MCT) currently relies on routine cytology to determine nodal metastasis. While frozen section nodal histopathology is commonly used in humans, its applicability to veterinary settings is p...
Clinical Response to Imatinib Mesylate and Toxicity Profile in 35 Dogs With Mast Cell Tumours [0.03%]
35例犬用美法仑治疗 mast细胞肿瘤的临床疗效及毒副作用观察
Elisabetta Treggiari,Emanuela Catania,Paola Valenti
Elisabetta Treggiari
Mast cell tumours (MCTs) are common in dogs. Treatment options include surgery, radiation therapy, and cytotoxic chemotherapy; however, in cases of inoperable or metastatic tumours, tyrosine kinase inhibitors (TKIs) can be used. Imatinib me...
Favourable Prognostic Significance of HER2 Mutations in Canine Pulmonary Adenocarcinoma Following Surgical Resection [0.03%]
术前赫尔利二型肺腺癌的良好预后意义
Masanao Ichimata,Yumiko Kagawa,Atsushi Toshima et al.
Masanao Ichimata et al.
Human epidermal growth factor receptor 2 (HER2) gene mutations have been reported in 5% to 38% of canine pulmonary adenocarcinomas (cPACs), most commonly as V659E mutations in exon 20. However, their prognostic and predictive significance r...