Receptor tyrosine kinase inhibitors: molecularly targeted drugs for veterinary cancer therapy [0.03%]
酪氨酸受体激酶抑制剂：兽医癌症治疗的分子靶向药物
S Bavcar,D J Argyle
S Bavcar
Tyrosine kinases (TKs) are key mediators of signalling pathways in cells. Located at the surface of the cell, within the cytoplasm or in the nucleous, TKs have been showed to be involved in regulation of normal cellular processes and also p...
Douglas H Thamm
Douglas H Thamm
Redox status evaluation in dogs affected by mast cell tumour [0.03%]
红细胞氧化状态在受 Mast Cell Tumour 病毒影响的狗中的评估
R Finotello,A Pasquini,V Meucci et al.
R Finotello et al.
Oxidative stress status has been evaluated in depth in human medicine and its role in carcinogenesis has been clearly established. The purpose of this prospective study was to evaluate antioxidant concentrations and oxidative stress in dogs...
Development of a limited-sampling model for prediction of doxorubicin exposure in dogs [0.03%]
用于预测犬多柔比星暴露量的限采样模型的建立
L A Wittenburg,D H Thamm,D L Gustafson
L A Wittenburg
Understanding the relationship between drug dose and exposure (pharmacokinetics, PK) and the relationship between exposure and effect (pharmacodynamics) is an important component of pharmacology when attempting to predict clinical effects o...
E Michel,C Rohrer Bley,M P Kowalewski et al.
E Michel et al.
Mammary tumours represent the most common neoplastic disease of the female dog, and the incidence in female dogs is much higher than in women. Whereas the influence of sexual steroids on breast cancer (BC) development in dogs has been studi...
Comparison between symptomatic treatment and lomustine supplementation in 71 dogs with intracranial, space-occupying lesions [0.03%]
71例颅内占位性病变犬对症治疗与配合使用洛莫司汀疗效的比较研究
S Van Meervenne,P S Verhoeven,J de Vos et al.
S Van Meervenne et al.
Brain neoplasia is diagnosed in an increasing number of dogs. Consequently, there is a higher need for an effective treatment. Chemotherapy is considered in cases where surgery or radiation is not optional. The objective of this retrospecti...
Use of adjuvant carboplatin for treatment of dogs with oral malignant melanoma following surgical excision [0.03%]
辅助使用卡铂治疗术后口腔恶性黑色素瘤的犬只
G Dank,K M Rassnick,Y Sokolovsky et al.
G Dank et al.
Melanoma is the most common oral malignancy in dogs. This retrospective study evaluated adjuvant carboplatin chemotherapy (with or without radiation therapy) in 17 dogs with malignant oral melanoma following surgical resection. The median d...
M N Mayer,T I Silver,C K Lowe et al.
M N Mayer et al.
The objective of this study was to develop a clinically applicable technique to visualize the medial retropharyngeal, superficial cervical, axillary, superficial inguinal and medial iliac lymph nodes on radiographs. Direct and indirect lymp...
Diagnostic accuracy of pre-treatment biopsy for grading soft tissue sarcomas in dogs [0.03%]
术前活检对犬软组织肉瘤分级诊断准确性的评估
J A Perry,W T N Culp,D D Dailey et al.
J A Perry et al.
Histologic grade is an important prognostic factor for both local recurrence and metastatic potential with canine soft tissue sarcoma (STS). Pre-treatment biopsy with identification of tumour grade may aid in prognostication and determinati...
M J Linderman,E M Brodsky,L-P de Lorimier et al.
M J Linderman et al.
Thirty-four cases were reviewed in this retrospective study for information on clinical presentation, prognostic indicators, survival time and response to various therapies. The most common presenting clinical signs were weight loss, decrea...