Novel acyclic nucleotide analogues GS-343074 and GS-424044 demonstrate antiproliferative and pro-apoptotic activity in canine neoplastic cell lines [0.03%]
新型环二核苷类似物GS-343074和GS-424044表现出对犬肿瘤细胞系的抗增殖及促凋亡作用
J A Lawrence,M K Huelsmeyer,D H Thamm et al.
J A Lawrence et al.
GS-9219, a novel prodrug of the nucleotide analogue 9-(2-phosphonylmethoxyethyl) guanine (PMEG) has significant activity as monotherapy in dogs with non-Hodgkin's lymphoma. Phase I trials have been initiated in humans based on the encouragi...
Adjuvant therapy with carboplatin and pamidronate for canine appendicular osteosarcoma [0.03%]
卡铂和帕米膦酸二钠治疗犬四肢骨肉瘤术后复发的效果研究
A R Kozicki,C Robat,R Chun et al.
A R Kozicki et al.
Amputation and chemotherapy are the mainstay of treatment for canine appendicular osteosarcoma (OSA). In vitro studies have demonstrated anti-tumour activity of pamidronate against canine OSA. The purpose of this study was to assess the saf...
Controlled Clinical Trial
Veterinary and comparative oncology. 2015 Sep;13(3):229-36. DOI:10.1111/vco.12040 2015
The use of COLD-PCR, DHPLC and GeneScanning for the highly sensitive detection of c-KIT somatic mutations in canine mast cell tumours [0.03%]
联合应用冷扩增 PCR、变性高效液相色谱法及基因扫描技术检测犬肥大细胞瘤c-KIT位点体细胞突变
F Gentilini,V Mantovani,M E Turba
F Gentilini
The conventional polymerase chain reaction (PCR)/sequencing methods may be poorly suited for the detection of somatic mutations in canine mast cell tumour (MCT) samples owing to limited sensitivity. This study was aimed at establishing nove...
Comparative Study
Veterinary and comparative oncology. 2015 Sep;13(3):218-28. DOI:10.1111/vco.12039 2015
Combined zoledronic acid and meloxicam reduced bone loss and tumour growth in an orthotopic mouse model of bone-invasive oral squamous cell carcinoma [0.03%]
联合使用唑来磷酸和美洛昔康可减少小鼠口咽部鳞状细胞癌原位骨转移模型中的骨量丧失及肿瘤生长
C K Martin,W P Dirksen,M M Carlton et al.
C K Martin et al.
Oral squamous cell carcinoma (OSCC) is common in cats and humans and invades oral bone. We hypothesized that the cyclooxygenase (COX)-2 inhibitor, meloxicam, with the bisphosphonate, zoledronic acid (ZOL), would inhibit tumour growth, osteo...
Response to letter by Dr Schulman regarding 'European consensus document on mast cell tumours in dogs and cats' [0.03%]
关于欧洲犬猫 mast细胞肿瘤共识文件的回信
L Blackwood,S Murphy,J Pastor
L Blackwood
MicroRNAs as tumour suppressors in canine and human melanoma cells and as a prognostic factor in canine melanomas [0.03%]
小鼠和人类黑色素瘤细胞中的微核糖核酸作为肿瘤抑制物以及在小鼠黑色素瘤中的预后因素
S Noguchi,T Mori,Y Hoshino et al.
S Noguchi et al.
Malignant melanoma (MM) is one of the most aggressive cancers in dogs and in humans. However, the molecular mechanisms of its development and progression remain unclear. Presently, we examined the expression profile of microRNAs (miRs) in c...
MicroRNAs as tumour suppressors in canine and human melanoma cells and as a prognostic factor in canine melanomas [0.03%]
microRNA在犬和人黑色素瘤细胞中的抑癌作用及其在犬黑色素瘤预后判断中的应用研究
S Noguchi,T Mori,Y Hoshino et al.
S Noguchi et al.
Malignant melanoma (MM) is one of the most aggressive cancers in dogs and in humans. However, the molecular mechanisms of its development and progression remain unclear. Presently, we examined the expression profile of microRNAs (miRs) in c...
Development and characterization of monoclonal antibodies to subgroup A avian leukosis virus [0.03%]
禽白血病病毒亚群A单克隆抗体的开发与表征
Y Qiu,X Li,L Fu et al.
Y Qiu et al.
Avian leukosis virus subgroup A (ALV-A) is a retrovirus which infects egg-type chickens and is the main pathogen of lymphoid leukosis (LL) and myeloid leukosis (ML). In order to greatly enhance the diagnosis and treatment of clinical avian ...
Pilot clinical study of carmustine associated with a lipid nanoemulsion in combination with vincristine and prednisone for the treatment of canine lymphoma [0.03%]
卡氮 mustard与脂质纳米乳剂联合长春新碱和泼尼松治疗犬淋巴瘤的I期临床研究
S R R Lucas,R C Maranhão,J L Guerra et al.
S R R Lucas et al.
A lipid nanoemulsion (LDE) resembling low-density lipoprotein can target malignant tumours. In in vivo and clinical studies, association of chemotherapeutic agents to LDE decreased their toxicity and increased pharmacological action. Here, ...
Randomized Controlled Trial
Veterinary and comparative oncology. 2015 Sep;13(3):184-93. DOI:10.1111/vco.12033 2015