Assessment of predictive molecular variables in feline oral squamous cell carcinoma treated with stereotactic radiation therapy [0.03%]
立体定向放射治疗猫口腔鳞状细胞癌的预测分子变量评估
H Yoshikawa,E J Ehrhart,J B Charles et al.
H Yoshikawa et al.
This study evaluated molecular characteristics that are potentially prognostic in cats with oral squamous cell carcinoma (SCC) that underwent stereotactic radiation therapy (SRT). Survival time (ST) and progression-free interval (PFI) were ...
Clinical Trial
Veterinary and comparative oncology. 2016 Mar;14(1):39-57. DOI:10.1111/vco.12050 2016
Prognostic value of baseline absolute lymphocyte concentration and neutrophil/lymphocyte ratio in dogs with newly diagnosed multi-centric lymphoma [0.03%]
新诊断的多中心淋巴瘤犬基线淋巴细胞绝对浓度和中性粒细胞与淋巴细胞比值的预后价值
M Mutz,B Boudreaux,M Kearney et al.
M Mutz et al.
Canine multi-centric B-cell lymphoma shares similarities with diffuse large B-cell (Non-Hodgkin's) lymphoma (NHL) in people. In people with NHL, lymphopenia at diagnosis and first relapse and neutrophil/lymphocyte ratio (N:L) > 3.5 are nega...
Canine indolent and aggressive lymphoma: clinical spectrum with histologic correlation [0.03%]
犬惰性和侵袭性淋巴瘤的临床分型及组织病理学相关性研究
L Aresu,V Martini,F Rossi et al.
L Aresu et al.
Sixty-three dogs with newly diagnosed lymphoma underwent complete staging and received the same chemotherapy. Diffuse large B-cell lymphoma was the leading histotype (44.4%), followed by peripheral T-cell lymphoma (20.6%). Indolent lymphoma...
Evaluation of 18F-FDG PET/CT as a diagnostic imaging and staging tool for feline oral squamous cell carcinoma [0.03%]
评估18F-FDG PET/CT在猫口腔鳞状细胞癌诊断和分期中的作用
E K Randall,S L Kraft,H Yoshikawa et al.
E K Randall et al.
18F-fluorodeoxyglucose positron emission tomography combined with computed tomography (18FDG-PET/CT) has been shown to be effective for staging human oral squamous cell carcinoma (SCC) but its application for cats with oral SCC is unknown. ...
The radiosensitizing effect of the aurora kinase inhibitors, ENMD-2076, on canine mast cell tumours in vitro [0.03%]
Aurora激酶抑制剂ENMD-2076增敏犬类髓细胞肿瘤的放射敏感性作用的体外研究
K Shiomitsu,E Sajo,C Rubin et al.
K Shiomitsu et al.
ENMD-2076 is an aurora kinase inhibitor that also has multi-target tyrosine kinase inhibitor properties. In this study, the mRNA and the protein expression of aurora-A and aurora-B were evaluated in three canine mast cell tumour cell lines....
Comparative analysis of MAPK and PI3K/AKT pathway activation and inhibition in human and canine melanoma [0.03%]
人和犬黑色素瘤中MAPK和PI3K/AKT通路活化及抑制的比较分析
J S Fowles,C L Denton,D L Gustafson
J S Fowles
The lack of advanced animal models of human cancers is considered a barrier to developing effective therapeutics. Canine and human melanomas are histologically disparate but show similar disease progression and response to therapies. The pu...
Comparative Study
Veterinary and comparative oncology. 2015 Sep;13(3):288-304. DOI:10.1111/vco.12044 2015
Flow-cytometric detection of phenotypic aberrancies in canine small clear cell lymphoma [0.03%]
流式细胞仪检测犬小透明细胞淋巴瘤表型异常
V Martini,A Poggi,F Riondato et al.
V Martini et al.
Histopathology and immunohistochemistry are mandatory to solve the differential between canine low-grade lymphoma and reactive hyperplasia. However, clinicians and owners often show reluctance toward these invasive tests. However, molecular...
Aggressive local therapy combined with systemic chemotherapy provides long-term control in grade II stage 2 canine mast cell tumour: 21 cases (1999-2012) [0.03%]
局部与全身联合治疗犬II级阶段2期肥大细胞肿瘤的长期控制：21例（1999-2012）
A Lejeune,K Skorupski,S Frazier et al.
A Lejeune et al.
This retrospective case series evaluates the outcome of 21 dogs with grade II stage 2 mast cell tumour (MCT) treated with adequate local therapy and adjuvant systemic chemotherapy (prednisone, vinblastine and CCNU). The median survival for ...
Inductively coupled plasma mass-spectrometric determination of platinum in excretion products of client-owned pet dogs [0.03%]
等离子体质谱法测定客户宠物犬排泄产物中的铂含量
T Janssens,E E M Brouwers,J P de Vos et al.
T Janssens et al.
Residues of antineoplastic drugs in canine excretion products may represent exposure risks to veterinary personnel, owners of pet dogs and other animal care-takers. The aim of this study was to measure the extent and duration of platinum (P...
A Kol,S L Marks,K A Skorupski et al.
A Kol et al.
Lymphoma is the most common haematopoietic malignancy in dogs and it has been associated with hypercoagulability and subsequent thromboembolism. The objectives of this study were to serially characterize the haemostatic status of dogs with ...