Generation of a Rabbit Anti-Canine CD19 Monoclonal Antibody From Peripheral Blood and Its Validation in Immunoassays and CAR-T Feasibility [0.03%]
基于外周血生成抗犬CD19单克隆抗体并应用于免疫检测及CAR-T可行性验证的研究
Huixin Li,Qiqi Lu,Xin Huang et al.
Huixin Li et al.
Lymphoma constitutes 24% of canine neoplastic diseases and 85% of haematopoietic tumours, with B-cell subtypes accounting for 60%-80% of cases. As the most prevalent spontaneous tumour in canines, this disease model holds significant transl...
Canine Urothelial DNA Mutations Are Not Associated With Total Trihalomethanes Concentrations in Municipal Drinking Water [0.03%]
城市饮用水中三卤甲烷浓度与犬黏膜上皮细胞DNA突变无关
Janice O&#x;Brien,Samantha L Braman,Jennifer Willcox et al.
Janice O&#x;Brien et al.
Contaminants in municipal drinking water, specifically total trihalomethanes (TTHMs), are mutagenic. Exposures to TTHMs have been associated with urothelial carcinoma (UC) in both people and dogs. Mutations in the BRAF gene and other genomi...
Hemangiosarcoma: A Systematic Review of Biomarkers in Diagnosis, Prognosis, and Therapeutic Strategies [0.03%]
血管肉瘤：诊断、预后和治疗策略的生物标志物系统评价
Sofie Vercammen,Huyen Thuc Tran Luong,Hilde De Cock et al.
Sofie Vercammen et al.
Hemangiosarcoma (HSA) in dogs is a malignant vascular tumour that exhibits rapid growth, frequent early metastasis, and resistance to conventional therapies, often resulting in short survival times. Building on our previous systematic revie...
Postmortem Detection of Blood Vascular Tumour-Cell Emboli in 31 Dogs: Macroscopic and Histological Findings [0.03%]
31例犬血管内肿瘤细胞栓子的死后检测：宏观和组织学发现
Helenize Molozzi,Vanessa Cirinéa Tapia Barraza,Valentina Berté Marcus et al.
Helenize Molozzi et al.
Despite the high prevalence of neoplastic diseases in dogs, tumour-cell embolism is poorly documented. This study aimed to characterise the presence and pathological features of distant blood vascular tumour-cell emboli (TCE) in dogs submit...
CD30 Expression in Neoplastic Mast Cells and the Presence of CD30+, CD3+, and PAX-5+ Tumour-Infiltrating Lymphocytes as Prognostic Markers in Canine Cutaneous Mast Cell Tumours [0.03%]
CD30在肿瘤肥大细胞中的表达及CD30+、CD3+和PAX-5+瘤浸润淋巴细胞的存在作为犬皮肤肥大细胞肿瘤预后标记物的意义
Fernanda Ramalho Ramos,Janayna Maria Parente Serafim,Bethânia Almeida Gouveia et al.
Fernanda Ramalho Ramos et al.
Canine cutaneous mast cell tumour (MCT) is the most common skin neoplasm in dogs, with histopathology serving as both the diagnostic and primary prognostic tool. However, identifying reliable biomarkers is essential for improving clinical d...
Epidemiology of Four Major Canine Tumours in the UK: Insights From a National Pathology Registry With Comparative Oncology Perspectives [0.03%]
英国四类主要犬肿瘤的流行病学：全国病理注册与比较肿瘤学视角下的启示
José Rodríguez,Antonio Espinosa de Los Monteros,Ángelo Santana et al.
José Rodríguez et al.
Pet dogs with naturally occurring cancers provide valuable models for comparative oncology and pathology tumour registries offer a powerful resource for onco-epidemiological research. Here, we analysed the Small Animal Veterinary Surveillan...
Whole Exome Sequencing of Feline Oral Squamous Cell Carcinoma Reveals Genomic Parallels With Human Head and Neck Squamous Cell Carcinoma [0.03%]
猫口腔鳞状细胞癌外显子组测序揭示其与人类头颈部鳞状细胞癌的基因组相似性
Shirley Chu,Zachary L Skidmore,Wes Warren et al.
Shirley Chu et al.
Feline oral squamous cell carcinoma (FOSCC) and human head and neck squamous cell carcinoma (HNSCC) are the 4th most common malignant neoplasms in cats and humans. Most cats are not treated due to the poor prognosis and die of their disease...
Tolerability and Adverse Event Profile of Fixed Dose Rate Gemcitabine in Dogs With Neoplasia [0.03%]
固定剂量率吉西他滨治疗肿瘤犬的耐受性和不良反应谱
Evangelia J Makrygiannis,Luke Wittenburg,Carlos O Rodriguez Jr et al.
Evangelia J Makrygiannis et al.
Fixed dose rate (FDR) gemcitabine offers pharmacokinetic advantages over bolus dosing, and there is evidence in human medicine that FDR gemcitabine is more effective than intravenous (IV) bolus. To date, literature describing gemcitabine us...
Comparison of Morbidity Between Sentinel Lymph Node Biopsy and Elective Neck Dissection in Dogs With Head and Neck Malignancies [0.03%]
比较头颈部恶性肿瘤犬前哨淋巴结活检与选择性颈清扫术的发病率
Lavinia Elena Chiti,Dominique Leu,Roberta Ferrari et al.
Lavinia Elena Chiti et al.
Elective neck dissection (END) and sentinel lymph node biopsy (SLNB) are suggested for nodal staging of canine head and neck malignancies (HNM). This study aims to compare the morbidity of END to SLNB. Seventy-six client-owned dogs with HNM...