Population Pharmacokinetics, Pharmacodynamics and Safety Properties of Trametinib in Dogs With Cancer: A Phase I Dose Escalating Clinical Trial [0.03%]
一项针对癌症犬的康奈非尼药代动力学、药效学和安全性的I期剂量递增临床试验
Marilia Takada,Keita Kitagawa,Yongzhen Zhang et al.
Marilia Takada et al.
MAPK has been reported as a key oncogenic pathway for canine histiocytic sarcoma, which can be pharmacologically targeted with trametinib, a small inhibitor of MEK1/2. Preliminary data showed promising antitumor activity in in vitro and in ...
One Health: Therapies Targeting Genetic Variants in Human and Canine Histiocytic and Dendritic Cell Sarcomas [0.03%]
从人和犬郎格汉斯细胞组织细胞增生症/朗格罕细胞肉瘤中鉴定的遗传变异的治疗靶点：针对人类和犬类组织细胞及树突状细胞肉瘤的一药多用疗法（One Health）
Suzanne Agnes Erich,Erik Teske
Suzanne Agnes Erich
The precise cause of HS/DCS is still unknown. The relatively low incidence in humans urges for an animal model with a high incidence to accelerate knowledge about genetics and optimal treatment of HS/DCS. Namely, until now, the therapies ta...
Sofia Chichorro Ramos,Patrícia Dias-Pereira,Ana Lúcia Luís et al.
Sofia Chichorro Ramos et al.
Electrochemotherapy (ECT) is a treatment modality that combines the electroporation of cell membranes with chemotherapy to facilitate the transport of non-permeant molecules into cells. Several canine and feline studies have shown promising...
Distribution of Inflammatory Infiltrate in Feline Mammary Lesions: Relationship With Clinicopathological Features [0.03%]
猫乳腺病变中炎症浸润的分布与临床病理特征的关系
Joana Rodrigues-Jesus,Ana Canadas-Sousa,Pedro Oliveira et al.
Joana Rodrigues-Jesus et al.
Inflammation is a frequent finding in feline mammary neoplasms. Recent research suggests that the presence and location of tumour-associated immune cells might play a significant role in the clinical outcome of feline mammary carcinomas. Th...
Pilot study to evaluate isolation by size of circulating tumour cells in canine oral melanoma [0.03%]
评估循环肿瘤细胞在犬口腔黑色素瘤中按大小隔离的试点研究
Victor Nowosh,Alexcia Camila Braun,Anna Paula Carreta Ruano et al.
Victor Nowosh et al.
Liquid biopsy for circulating tumour cell (CTC) detection is generally unexplored in veterinary medicine. Dogs with highly aggressive and heterogeneous tumours, such as oral malignant melanoma (OMM), could benefit from studies involving siz...
Immunohistochemical and transcriptomic characterization of T and myeloid cell infiltrates in canine malignant melanoma [0.03%]
犬恶性黑色素瘤中T细胞和髓系细胞浸润的免疫组化及转录组特征分析
Kathryn E Cronise,Jonathan Coy,Steven Dow et al.
Kathryn E Cronise et al.
Immune checkpoint inhibitor therapy can provide significant clinical benefit in patients with certain cancer types including melanoma; however, objective responses are only observed for a subset of patients. Mucosal melanoma is a rare melan...
Identification of hypoxia-induced metabolism-associated genes in canine tumours [0.03%]
犬肿瘤缺氧诱导的代谢相关基因的鉴定
Taiki Kato,Masashi Sakurai,Kenji Watanabe et al.
Taiki Kato et al.
Canine tumours including urothelial carcinoma, lung adenocarcinoma, mammary gland tumour, squamous cell carcinoma, and melanoma have been identified as causes of death, but effective therapies are limited due to insufficient knowledge of th...
Characterization of the dissemination of canine cancer misinformation on YouTube [0.03%]
YouTube上犬类癌症错误信息传播的特征研究
Eliza R Richartz,Brittany A Hodgkiss,Noah C Black-Ocken et al.
Eliza R Richartz et al.
YouTube is the third most popular app in the world and continues to grow each year while it reaches over 2 billion users a month. A variety of veterinary topics are addressed on YouTube but to date there have been no studies analysing misin...
Effective detection of BRAFV595E mutation in canine urothelial and prostate carcinomas using immunohistochemistry [0.03%]
免疫组化有效检测犬尿路上皮和前列腺癌中BRAF V595E突变
Leonore Aeschlimann,Alexandra Kehl,Franco Guscetti et al.
Leonore Aeschlimann et al.
Canine urothelial carcinoma (UC) and prostate carcinoma (PC) frequently exhibit the BRAFV595E mutation, akin to the BRAFV600E mutation common in various human cancers. Since the initial discovery of the BRAF mutation in canine cancers in 20...
Evaluation of clinical response and prognostic factors in canine multicentric lymphoma treated with first rescue therapy [0.03%]
评估犬多中心淋巴瘤初次挽救治疗的临床疗效及预后因素
John E Blaxill,Peter F Bennett
John E Blaxill
Despite an initial strong response in most dogs with multicentric lymphoma treated with chemotherapy, relapse remains common. There is no clearly superior first rescue protocol described either for resistant or relapsed canine multicentric ...
Multicenter Study
Veterinary and comparative oncology. 2024 Jun;22(2):265-277. DOI:10.1111/vco.12974 2024