Loss of ABCA3 disrupts lipid balance and leads to AMPK-dependent suppression of SREBP1 in glioblastoma stem cells [0.03%]
ABCA3丢失破坏脂质稳态并导致AMPK依赖性抑制胶质母细胞瘤干细胞中的SREBP1
Jun-Kyum Kim,Min Gi Park,Seok Won Ham et al.
Jun-Kyum Kim et al.
Malignant cancers exhibit distinct lipid metabolic features that support tumor initiation and progression. Glioblastoma (GBM) is an aggressive brain tumor driven by GBM stem cells (GSCs), which are responsible for tumor development and ther...
TRIM21-mediated degradation of HILPDA overcomes anti-PD-1 immunotherapy resistance in breast cancer by limiting PD-L1 palmitoylation [0.03%]
通过限制PD-L1棕榈酰化介导的HILPDA降解可克服抗PD-1免疫疗法在乳腺癌中的耐药性
Xi Wang,Guangyan Li,Jiaming Wu et al.
Xi Wang et al.
Immune checkpoint blockade (ICB) targeting PD-1/PD-L1 improves outcomes across multiple malignancies, yet resistance to immune checkpoint blockade remains common. Here, we identify HILPDA as a tumor-intrinsic regulator of immune evasion in ...
Non-classic deubiquitinase USP13 inhibits bladder cancer metastasis through destabilizing cytoplasmic KDM3A [0.03%]
非经典的脱泛素酶USP13通过使KDM3A去稳定化来抑制膀胱癌的转移
Hongji Hu,Xiangpeng Zhan,Yunqiang Xiong et al.
Hongji Hu et al.
The paper ( https://doi.org/10.1038/s41388-025-03410-3 ) was retracted due to the use of a contaminated cell line; after communication with the original journal's editors, we have obtained permission to replace the cell line and resubmit th...
PAK4 functions as an immune suppressor by reprogramming the phosphatidylcholine metabolism of CD8 + T cells within the glioblastoma tumor microenvironment [0.03%]
pak4通过重新编程胶质母细胞瘤肿瘤微环境内cd8+t细胞的卵磷脂代谢发挥免疫抑制作用
Lin Yao,Heyang Gao,Zuopeng Su et al.
Lin Yao et al.
Glioblastoma multiforme (GBM) is a highly aggressive primary brain tumor that represents a significant therapeutic challenge because of its immunosuppressive tumor microenvironment (TME). GBM employs multiple sophisticated mechanisms for im...
Aryl hydrocarbon receptor is critical for both AR-dependent and AR-indifferent enzalutamide resistance in castration-resistant prostate cancer [0.03%]
芳烃受体在去势抵抗性前列腺癌雄激素剥夺治疗耐药中发挥关键作用
Chia-Hui Chen,Ryan Brown,Donald J Vander Griend et al.
Chia-Hui Chen et al.
The introduction of next-generation androgen receptor signaling inhibitors (ARSIs) like enzalutamide (ENZ), has improved the clinical management of castration-resistant prostate cancer (CRPC). However, acquired resistance to these therapies...
Cancer-associated fibroblasts as key regulators of lipid metabolism in the tumour microenvironment [0.03%]
肿瘤微环境中癌相关成纤维细胞对脂质代谢的关键调控作用
Jessamy Adams,Caterina M Suelzu,Gabriele Strusi et al.
Jessamy Adams et al.
Alterations in metabolism are recognised as a hallmark of cancer, allowing for rapid proliferation in an environment often hypoxic and short of nutrients. Cells within the tumour microenvironment (TME) often undergo metabolic alterations to...
PRSS22 inhibits HMOX1-mediated ferroptosis and induces osteopontin cleavage to promote M2 macrophage polarization and colitis-associated carcinogenesis [0.03%]
脯氨酰寡肽还原酶22通过抑制HMOX1介导的铁死亡和促进骨桥蛋白裂解来促进M2型巨噬细胞极化及结肠炎相关性癌症发生
Zijian Kuang,Qiliang Su,Wenken Liang et al.
Zijian Kuang et al.
Cancer cells exhibit abnormally altered proteome to satisfy the metabolic demands that arise from heightened proliferation. Trypsin-like serine proteases are a class of proteolytic enzymes whose expression is often dysregulated in cancer. S...
LINC-AC092535.5 regulates MICAL2 mRNA level to inhibit p53-mediated ferroptosis in nasopharyngeal carcinoma [0.03%]
长链非编码RNA LINC-AC092535.5通过调控MICAL2表达抑制鼻咽癌铁死亡发生
Siyu Zhang,Wenyue Chen,Ji Yang et al.
Siyu Zhang et al.
Ferroptosis is a form of iron-dependent programmed cell death (PCD) that, once activated, inhibits tumor progression. However, the specific mechanisms influencing ferroptosis in nasopharyngeal carcinoma (NPC) are limited and warrant further...
METTL16 enhances proteasome inhibitor resistance in multiple myeloma by inhibiting eIF2α-PERK interaction and promoting PSMB5 translation [0.03%]
METTL16通过抑制eIF2α-PERK相互作用并促进PSMB5翻译来增强多发性骨髓瘤对蛋白酶体抑制剂的耐药性
Guanli Wang,Xuejie Gao,Hui Zhang et al.
Guanli Wang et al.
Proteasome inhibitor (PI) resistance remains a major barrier in the treatment of multiple myeloma (MM), underscoring the urgent need to elucidate underlying mechanisms and identify actionable therapeutic targets. Here, we uncover METTL16 as...
Cereblon (CRBN) inhibits prostate cancer metastasis by negatively regulating 6-phosphogluconate dehydrogenase (6PGD) [0.03%]
泛素连接酶Cereblon(CRBN)通过抑制6-磷酸葡萄糖脱氢酶(6PGD)促进前列腺癌转移的作用及机制研究
Koushik Guchhait,Hyeon-Seung Yoon,Hyun-Su An et al.
Koushik Guchhait et al.
Metastasis is the primary cause of mortality in advanced prostate cancer, and the emergence of resistance to androgen receptor (AR)-targeted therapies highlights the urgent need for alternative therapeutic strategies. Metabolic reprogrammin...