Fusobacterium nucleatum drives colorectal cancer progression through the circPTBP3/miR-760/PUM1 axis [0.03%]
核梭杆菌通过circPTBP3/miR-760/PUM1轴促进结直肠癌进展
Chunmin Li,Qianqian Liu,Hangchang Shen et al.
Chunmin Li et al.
Circular RNAs (circRNAs) perform critical functions in cancer biology, commonly serving as microRNA (miRNA) sponges to modulate gene expression. Nevertheless, their participation in gut microbiota-driven colorectal cancer (CRC) has yet to b...
Oncogenic LPP facilitates focal adhesion maturation in response to mechanical tension and regulates the Hippo signaling [0.03%]
致癌性LPP促进焦点粘附成熟以响应机械张力并调节Hippo信号传导
Liu Huang,Ganlu Sun,Mingyu Li et al.
Liu Huang et al.
LIM family proteins play pivotal roles in mechano-transduction, a process often dysregulated in human cancers. However, the functions and mechanisms of LIM proteins in tumor biology remain insufficiently characterized. In this study, we dem...
OTUB1/CDYL axis-mediated epigenetic repression of SOX18 facilitates lung cancer progression by inhibiting FDX1-dependent cuproptosis [0.03%]
OTUB1/CDYL轴介导的SOX18表观遗传抑制通过抑制FDX1依赖性铜死亡促进肺癌进展
Ruike Zhang,Yang Li,Hongshen Lu et al.
Ruike Zhang et al.
Lung cancer persists as a major contributor to global cancer-related mortality, with metastasis, recurrence, and therapy resistance posing substantial barriers to effective disease management. CDYL has gained recognition as an epigenetic co...
The YY1-KIF15-PRDX1 axis promotes gastric cancer progression by inducing mitochondrial ROS imbalance [0.03%]
YY1-KIF15-PRDX1轴通过诱导线粒体ROS失衡促进胃癌进展
Wenjie Li,Bozhi Wu,Haisheng Qian et al.
Wenjie Li et al.
Gastric cancer (GC) remains a leading cause of global cancer mortality, necessitating deeper molecular insights. This study identifies KIF15 as a key driver of GC progression through integrated analysis of TCGA data and experimental validat...
In vitro models of cell competition: current approaches and future directions [0.03%]
细胞竞争的体外模型：当前方法及未来方向
Selami Baglamis,Przemek M Krawczyk,Louis Vermeulen et al.
Selami Baglamis et al.
Cell competition is an evolutionarily conserved quality control mechanism that eliminates less-fit cells to ensure optimal tissue integrity during development, homeostasis, and regeneration. Beyond these physiological roles, recent evidence...
Retraction Note: Long non-coding RNA SNHG5 suppresses gastric cancer progression by trapping MTA2 in the cytosol [0.03%]
撤回 notice: lncRNA SNHG5通过在细胞质中捕获MTA2抑制胃癌的发展
L Zhao,H Guo,B Zhou et al.
L Zhao et al.
Colony-stimulating factor-2 triggers NNMT-dependent myofibroblast activation in head and neck cancer [0.03%]
集落刺激因子-2通过依赖NNMT的方式触发头颈部癌症中的肌成纤维细胞活化
Rui Li,Xiao Yang,Yitong Li et al.
Rui Li et al.
Myofibroblastic cancer-associated fibroblasts (myoCAFs) represent a crucial stromal cell subpopulation associated with tumor growth, relapse, and metastasis. In this study, we identify a noncanonical mechanism through which head and neck ca...
CAPRIN1-mediated sequestration of NCOA4 mRNA into stress granules drives sorafenib resistance in hepatocellular carcinoma [0.03%]
载脂蛋白CAPRIN1介导的NCOA4 mRNA纳入应激颗粒驱动肝细胞癌索拉非尼耐药性
Mengyao Wang,Gengde Hong,Chengyue Zhang et al.
Mengyao Wang et al.
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality, with therapeutic resistance posing a critical barrier to improving patient outcomes. While stress granules (SGs) are implicated in tumor adaptation, their m...
The NPC1/USP7/p53 axis regulates cholesterol and promotes the proliferation of hepatocellular carcinoma [0.03%]
NPC1/USP7/p53信号轴调控胆固醇并促进肝癌细胞增殖
Ru Deng,Xiaoming Zheng,Feihong Liu et al.
Ru Deng et al.
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality globally; however, the molecular drivers remain unclear. Dysregulated cholesterol metabolism is a hallmark of HCC and contributes to tumor progression. The Nieman...
ZDHHC9-mediated KLF5 palmitoylation enhances the cAMP/PKA/CREB axis to promote colorectal cancer progression [0.03%]
ZDHHC9介导的KLF5棕榈酰化增强了cAMP/PKA/CREB轴以促进结直肠癌进展
Hao Zhang,Yuan Tian,Zeyu Xiang et al.
Hao Zhang et al.
S-palmitoylation, a reversible lipid-based post-translational modification, is notably elevated in colorectal cancer (CRC) due to common lipid metabolism disorders. It has been reported to play crucial roles in regulating membrane compositi...