Laura Zafrany,Rui Wu,Amy Melsaether et al.
Laura Zafrany et al.
Rho-associated coiled-coil kinases (ROCKs) regulate the actin cytoskeleton by controlling cellular functions such as cell contraction, migration and adhesion. Within the ROCK family, two highly homologous isoforms with overlapping functions...
Strand-asymmetric G-runs and G4s downstream of TSS modulate tumor suppressor gene transcription [0.03%]
染色体不对称的G碱基重复序列和TSS下游的G四联体调节抑癌基因转录
Dan Huang,Xiaoting Zhang,Xiansong Wang et al.
Dan Huang et al.
A genome sequence is not made up of random nucleotides. Instead, it has distinctive features for evolutionary adaptation. Herein, we identified a higher frequency of continuous guanines (G-runs) located downstream of the transcription start...
M6A-dependent upregulation of ZNF460 promotes epithelial-mesenchymal transition and metastasis of gastric cancer through a histone modification-mediated positive feedback loop [0.03%]
M6A依赖的ZNF460上调通过组蛋白修饰介导的正反馈环促进胃癌上皮间质转化和转移
Ben Yue,Chenlong Song,Tianshang Bao et al.
Ben Yue et al.
The regulatory role of TGF-β-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination is well established, but the involvement of N6-methyladenosine (m6A) in TGF-β signaling remains obscure. Here, we unveil, for the fi...
Correction: The multifunctional RNA helicase DDX39A drives glioblastoma progression by modulating WISP1 alternative splicing that induces an immunosuppressive macrophage polarization [0.03%]
纠正：多功能RNA解旋酶DDX39A通过调节WISP1可变剪接诱导免疫抑制性巨噬细胞极化而驱动胶质母细胞瘤进展
Yan Zhang,Zhiwei Xue,Naibin Zhang et al.
Yan Zhang et al.
Published Erratum
Oncogene. 2026 Apr;45(15):1399. DOI:10.1038/s41388-026-03756-2 2026
STAT3-mediated transactivation of NOVA2 promotes lung adenocarcinoma metastasis by splicing SMAD4 [0.03%]
STAT3介导的NOVA2转录激活通过剪接SMAD4促进肺腺癌转移
Shengjie Wang,Xin Tong,Runfeng Sun et al.
Shengjie Wang et al.
Metastasis remains the primary cause of mortality in lung adenocarcinoma (LUAD) patients. However, the molecular mechanisms underlying LUAD cell metastasis are only partially elucidated. Here, by performing integrated bioinformatic analysis...
X-linked cancer-associated polypeptide (XCP) from lncRNA1456 modulates PHF8 histone demethylase activity to regulate the epigenome, gene expression, and cellular pathways in breast cancer [0.03%]
长链非编码RNA lncRNA1456衍生的X染色体癌相关多肽(XCP)通过调节PHF8组蛋白去甲基酶活性来调控乳腺癌中的表观基因组、基因表达和细胞途径
Shrikanth S Gadad,Cristel V Camacho,Xuan Gong et al.
Shrikanth S Gadad et al.
Recent studies have demonstrated that a subset of long "noncoding" RNAs (lncRNAs) produce functional polypeptides and proteins. In this study, we discovered a 132 amino acid protein in human breast cancer cells named XCP (X-linked Cancer-as...
Targeting FTO shows therapeutic potential in esophageal squamous cell carcinoma by modulating microRNA biogenesis [0.03%]
靶向FTO通过调节microRNA生物发生展示出治疗食管鳞状细胞癌的潜力
Wei Zhou,Chunyan Wang,Changhao Li et al.
Wei Zhou et al.
N6-methyladenosine (m6A) RNA modification is a pivotal post-transcriptional regulator of RNA metabolism and cancer progression. Fat mass and obesity-associated protein (FTO), an m6A demethylase, has emerged as a potent oncogenic driver acro...
LDHA-driven lactate metabolism promotes MDSC activation and immunosuppressive microenvironment in prostate cancer [0.03%]
丙酮酸乳酸脱氢酶A驱动的乳酸代谢促进前列腺癌微环境中髓系衍生抑制细胞的活化及免疫抑制微环境的形成
Xiyi Wei,Xiao Li,Yitong Pan et al.
Xiyi Wei et al.
Immunotherapy has achieved limited efficacy in prostate cancer (PCa), largely due to its profoundly immunosuppressive tumor microenvironment (TME). However, the metabolic mechanisms underpinning this immune resistance remain poorly defined....
Editorial Expression of Concern: GRP78 regulates clusterin stability, retrotranslocation and mitochondrial localization under ER stress in prostate cancer [0.03%]
编辑部关注函：GRP78在内质网压力下调节前列腺癌中的簇素稳定性、逆行转运和线粒体定位
N Li,A Zoubeidi,E Beraldi et al.
N Li et al.
Dual function of DOT1L suppresses tumor cell-intrinsic immunogenicity in hepatocellular carcinoma [0.03%]
DOT1L的双重功能可抑制肝癌细胞内在免疫原性
Siyuan Xu,Ruijie Gong,Songchen Liu et al.
Siyuan Xu et al.
Immune checkpoint blockade (ICB) therapy for many cancers remains limited in patients' overall response rate. Discovery and development of more effective combinatorial approaches is urgent. Here, through CRISPR/Cas9 genetic screens, we iden...