A genome-wide CRISPR screen in human prostate cancer cells reveals drivers of macrophage-mediated cell killing and positions AR as a tumor-intrinsic immunomodulator [0.03%]
人前列腺癌细胞的全基因组CRISPR筛选揭示了巨噬细胞介导的细胞杀伤的驱动因素，并将AR定位为肿瘤固有的免疫调节因子
Anniek Zaalberg,Audrey Lacoste,Emma Minnee et al.
Anniek Zaalberg et al.
Macrophages are the most abundant immune cells in the prostate tumor microenvironment and capable of killing tumor cells, but tumor intrinsic modulators of resistance to the innate immune system are unknown. To identify genes essential for ...
Enhancing the efficacy of B7-H3-targeting antibody-drug conjugate DS-7300a in TP53-deficient tumors by inducing ferroptosis [0.03%]
通过诱导铁死亡增强TP53缺陷肿瘤中靶向B7-H3的抗体药物偶联物DS-7300a的疗效
Javier Leo,Feiyu Chen,Wei Shi et al.
Javier Leo et al.
Immune checkpoint B7-H3 is an emerging target for immunotherapy. DS-7300a is an advanced B7-H3-targeting antibody-drug conjugate (ADC) warheaded with the topoisomerase I inhibitor DXd. DS-7300a has demonstrated clinical activity, but molecu...
The epigenetic KMT5C-HDAC1 axis promotes hepatocellular carcinoma stemness and progression through SERPINA4 repression and chromatin compaction [0.03%]
表观遗传KMT5C-HDAC1轴通过SERPINA4抑制和染色质压缩促进肝癌干细胞特性及恶性进展
Hongbin Huang,Caini Huang,Pangfei Yang et al.
Hongbin Huang et al.
Epigenetic dysregulation is a hallmark of hepatocellular carcinoma (HCC), yet the mechanisms linking chromatin modifiers to tumor stemness remain incompletely understood. Here, we identify the histone methyltransferase KMT5C as master regul...
USP15-mediated deubiquitination of FIS1 impairs mitochondrial function and sensitizes bladder cancer cells to radiotherapy [0.03%]
USP15介导的FIS1去泛素化抑制线粒体功能并使膀胱癌细胞对放疗产生敏感性
Ruxin Xiong,Mingxu Wang,Jiaming Du et al.
Ruxin Xiong et al.
While radiation therapy plays a pivotal role in the treatment of advanced invasive bladder cancer, its efficacy is often limited when used as alone, underscoring the need to identify molecular targets that regulate radiosensitivity. In this...
The phase separation of ZC3H18 transcriptionally activates LDHA and forms lactylation-mediated positive feedback loop to promote tumorigenesis of lung cancer [0.03%]
ZC3H18的相分离通过转录活化LDHA并形成乳酰化介导的正反馈环路来促进肺癌的发生发展
Dandan Yin,Chang Zhang,Yuancheng Li et al.
Dandan Yin et al.
RNA-binding proteins (RBPs) play crucial roles in tumorigenesis and cancer treatment. As metabolic reprogramming is known to participate in tumorigenesis, elucidation of the mechanisms of crosstalk between RBPs and metabolism could provide ...
tRNA-derived small RNAs in tumor microenvironment remodeling: From mechanistic insights to therapeutic perspectives [0.03%]
肿瘤微环境重塑中的tRNA衍生的小RNA：从机制见解到治疗展望
Yaguang Zhang
Yaguang Zhang
Transfer RNA-derived small RNAs (tsRNAs) represent an emerging class of non-coding RNAs involved in gene expression and cellular homeostasis. Growing evidence suggests that tsRNAs contribute to tumor initiation and progression, in part by r...
Thioredoxin interacting protein (TXNIP), a redox regulator, mediates the EPAC-RAP1 signaling dependency of primary melanoma [0.03%]
硫氧还蛋白相互作用蛋白(TXNIP)，一种氧化还原调节因子，介导EPAC-RAP1信号依赖性的一期黑色素瘤
Sireesh Kumar Teertam,Mithalesh K Singh,Sarah Altameemi et al.
Sireesh Kumar Teertam et al.
Progression of cutaneous primary melanoma that arises from melanocytes leads to lethal metastatic disease. Molecular mechanisms that control the growth of primary melanoma in the skin and promote progression are not fully understood. Previo...
Autocrine CysLT1R-ERK/YAP signaling drives melanoma progression and reveals a targetable oncogenic GPCR axis [0.03%]
自分泌CysLT1R-ERK/YAP信号驱动黑色素瘤进展并揭示一个可靶向的致癌G蛋白偶联受体轴
Emma Elizabeth Sabu Kattuman,Lakshminarayan Reddy Teegala,Venkatesh Katari et al.
Emma Elizabeth Sabu Kattuman et al.
Cutaneous melanoma remains the most lethal skin cancer due to profound tumor heterogeneity and the frequent development of resistance to current therapies. Here, we identify the cysteinyl leukotriene receptor 1 (CysLT1R) as a previously unr...
RON receptor tyrosine kinase regulates abiraterone resistance in prostate cancer via the methylation-dependent and independent dual functions of DNMT1 [0.03%]
RON受体酪氨酸激酶通过DNMT1的甲基化依赖和非依赖性双重功能调节前列腺癌中的阿比特龙耐药性
Ke-Jie Wang,Kai-Yun Wang,Si-Xi Chen et al.
Ke-Jie Wang et al.
Acquired resistance to the CYP17 inhibitor abiraterone is a critical challenge in the clinical treatment of metastatic prostate cancer; however, the mechanisms driving this resistance remain elusive. This study suggests that aberrant RON ex...
DTX3 promotes anti-tumor immunity by inducing PD-L1 ubiquitination and is suppressed by p65/miR-222 in bladder cancer [0.03%]
DTX3通过诱导PD-L1泛素化促进膀胱癌的抗肿瘤免疫并受到p65/miR-222抑制
Yu Cheng,Ya Chen,JiaYu Wang et al.
Yu Cheng et al.
The limited efficacy of programmed death ligand-1 (PD-L1)/programmed death 1 (PD-1) immunotherapy remains a major challenge in bladder cancer (BC). Here, we identified Deltex E3 ubiquitin ligase 3 (DTX3) as a negative regulator of PD-L1 exp...