Carbohydrate responsive element binding protein promotes colorectal carcinogenesis via Wnt/β-catenin pathway [0.03%]
碳水化合物反应元件结合蛋白通过Wnt/β-连环蛋白信号通路促进结直肠癌发生发展
Ming Feng,Wenrui He,Guoxiao Ji et al.
Ming Feng et al.
Despite significant advances in colorectal cancer (CRC) diagnosis and treatment, drug therapy of CRC patients is still confronted with considerable challenges. Carbohydrate response element-binding protein (ChREBP), a glucose-responsive tra...
Suppression of PP2A-B56α drives EMT in EGFR mutant non-small cell lung cancer [0.03%]
PP2A-B56α的抑制驱动EGFR突变非小细胞肺癌的上皮间质转化
Brittany N Heil,Garima Baral,Claire M Pfeffer et al.
Brittany N Heil et al.
Lung cancer is the leading cause of cancer-related deaths in the United States, and ~50% of these patients present with metastatic disease at diagnosis. Epithelial-to-Mesenchymal Transition (EMT) is an important initiating step in the metas...
HERC1 oncogene enhances stemness and tumorigenic potential in CD44+-derived organoids of head and neck squamous cell carcinoma through IL-6/STAT3 signaling [0.03%]
HERC1癌基因通过IL-6/STAT3信号通路增强头颈部鳞状细胞癌CD44+衍生类器官的干性和致瘤潜能
Eunjin Jeong,Hye Lin Kim,Seohee Park et al.
Eunjin Jeong et al.
HECT and RCC1-like domain-containing protein 1 (HERC1), a large E3 ubiquitin ligase, has been implicated in neural development and genome stability, but its role in cancer remains unclear. This study identifies HERC1 as a critical regulator...
The impact of K-Ras Gly12 mutants on homeostasis and tumorigenesis in the colonic epithelium [0.03%]
K-Ras Gly12位点突变对结肠上皮稳态及肿瘤发生的影响
Moon Hee Yang,Shikha Sheth,Bing Shui et al.
Moon Hee Yang et al.
K-Ras represents one of the most frequently mutated and therapeutically relevant oncogenic drivers. Clinical and epidemiological data suggest association between specific KRAS alleles, therapeutic responses, and patient outcomes, however, d...
Wnt signaling and the tumor microenvironment: implications for cancer progression and therapeutics [0.03%]
Wnt信号通路与肿瘤微环境：对癌症进展和治疗的影响
Ashok Bharathy Mariappan Ragupathi,Chi V Dang,Daniel J Zabransky
Ashok Bharathy Mariappan Ragupathi
The Wnt (Wingless/Integrated) signaling pathway is a highly conserved regulator of development, stem cell maintenance, and tissue homeostasis. Its dysregulation is a hallmark of cancer, driving uncontrolled proliferation, epithelial-mesench...
Plasmin promotes hepatocellular carcinoma invasion and metastasis via CXCR4-mediated activation of PI3K/AKT/mTOR signaling [0.03%]
纤溶酶通过CXCR4活化PI3K / AKT / mTOR信号促进肝癌侵袭和转移
Zhiyuan Shen,Yuexing Yang,Tianyu Mao et al.
Zhiyuan Shen et al.
Cancer-associated hyperfibrinolysis are potentially fatal outcomes of advanced cancer. Unfortunately, this knowledge has not yet led to any breakthrough in cancer therapy. Plasmin is the key enzyme of fibrinolytic system. The identification...
Multi-omics approaches reveal erythroid progenitor cell in cancer: from passive bystander to active player [0.03%]
多组学方法揭示出癌症中的红系祖细胞：从旁观者到参与者
Zi-Zhan Li,Cheng-Ke Zhou,Zhi-Jun Sun
Zi-Zhan Li
Cancer remains a leading cause of human mortality worldwide, imposing a substantial public health burden. A deep understanding of the tumor microenvironment (TME) is essential for improving cancer care. Erythroid progenitor cells (EPCs) wer...
PIAS4 inhibition induces cell cycle arrest and exhibits a synergistic effect in combination with CDK4/6 inhibitor in breast cancer treatment [0.03%]
PIAS4抑制可诱导细胞周期停滞并与CDK4/6抑制剂联合使用可在乳腺癌治疗中产生协同作用
Hui Chen,Xinyang Hu,Lifeng Feng et al.
Hui Chen et al.
Protein post-translational modifications are crucial in driving cancer development and progression. The SUMO E3 ligase PIAS4 regulates various cellular processes, thereby promoting tumour advancement. However, the role of PIAS4 in breast ca...
SETDB2 induces abnormal SHP-1 splicing and promotes immunosuppression in hepatocellular carcinoma [0.03%]
SETDB2诱导癌胚抗原异常剪接并促进肝细胞癌免疫抑制作用
Qinlian Jiao,Yidan Ren,Xin Su et al.
Qinlian Jiao et al.
The clinical application of targeted therapy and immune checkpoint inhibitors (ICIs) has significantly improved the survival prognosis of patients with hepatocellular carcinoma (HCC). However, due to the high heterogeneity of HCC, the respo...
NSUN2/ALYREF-mediated RNA m5c modification promotes anoikis resistance of prostate cancer through activating autophagy [0.03%]
NSUN2/ALYREF介导的RNA m5C修饰通过激活自噬促进前列腺癌细胞抗脱落性抵抗
Guangyu Sun,Shuaiqi Chen,Mingzhe Chen et al.
Guangyu Sun et al.
Prostate cancer is the most common malignant tumor among men worldwide, severely threatening the health of aging males. RNA 5-methylcytosine (m5C) modification has been demonstrated to play a significant role in the initiation and progressi...