MTPN drives noncanonical ERK hyperactivation in colorectal cancer and provides a promising therapeutic approach for precision medicine in CRC [0.03%]
MTPN驱动结直肠癌非经典ERK过度活化并为其精准医疗提供有希望的治疗策略
Chushu Li,Shouyan Deng,Minxian Zhuang et al.
Chushu Li et al.
Efforts to block the mitogen-activated protein kinase (MAPK) pathway for colorectal cancer (CRC) therapy are challenged by frequent oncogenic mutations of its upstream genes, robust extracellular signal-regulated kinase (ERK) reactivation a...
Thr3/Ser90 phosphorylation-stabilized S100A8 regulates cholesterol metabolism in glioblastoma stem cells [0.03%]
Thr3/Ser90磷酸化增强的S100A8调节胶质母细胞瘤干细胞中的胆固醇代谢
Wanzhi Cai,Jingming Hu,Chengzhi Chen et al.
Wanzhi Cai et al.
Glioblastoma (GBM) exhibits profound therapy resistance and inevitable recurrence, driven predominantly by glioblastoma stem cells (GSCs). S100A8 is positively associated with glioblastoma malignancy, but its expression and molecular mechan...
USP13 stabilizes SOCS1 to reverse αPD-1 resistance in MSI-H colorectal cancer [0.03%]
USP13通过稳定SOCS1逆转微卫星高度不稳定型结直肠癌的抗αPD-1抗体耐药性
Zhijian Zheng,Yuqi Ni,Ming Wu et al.
Zhijian Zheng et al.
Immune checkpoint blockade (ICB) has shown substantial efficacy in microsatellite instability-high (MSI-H) colorectal cancer (CRC), but resistance to αPD-1 therapy remains a major clinical challenge. The role and mechanism of deubiquitinat...
Sirt1 sustains Sonic hedgehog signaling to promote medulloblastoma progression through regulating Gli3 processing [0.03%]
Sirt1通过调节Gli3加工促进 sonic hedgehog信号传导以促进髓母细胞瘤的发展
Jian Hu,Chaonan Zheng,Yingying Feng et al.
Jian Hu et al.
Medulloblastoma (MB) is the most common malignant pediatric brain tumor with poor prognosis, high recurrence, and severe treatment-related toxicities. One-third of MB are driven by aberrant activation of the Sonic hedgehog (SHH) signaling p...
iPalmT: a new paradigm for palmitoyltransferase discovery via end-to-end deep learning [0.03%]
基于端到端深度学习的新型棕榈酰转移酶发现方法-iPalmT
Tengda Li,Xiang Li
Tengda Li
Protein S-palmitoylation, a dynamic lipid modification, is essential for protein stability, trafficking, and signaling; dysregulated palmitoyltransferases drive cancer, yet systematic discovery of palmitoyltransferases remains hindered by l...
Granzyme B-based CAR-T cells targeting membrane-bound HSP70 suppress solid tumor growth and metastasis [0.03%]
基于Granzyme B的靶向膜结合型HSP70的CAR-T细胞可抑制实体瘤生长和转移
Bin Sun,Jing Guo,Dong Yang et al.
Bin Sun et al.
Utilizing CAR-T cells to eliminate circulating tumor cells (CTCs) and inhibit metastasis is a promising strategy. However, this approach is hindered by the lack of specific antigens. Membrane-bound HSP70 (mHSP70) is commonly expressed on th...
Antitumor immunotoxin expression is enhanced by Escherichia coli csrB-promoter activity [0.03%]
大肠杆菌csrB-启动子活性增强抗肿瘤免疫毒素表达
Seyeon Hong,Sung-Gwon Lee,Dogeun Lee et al.
Seyeon Hong et al.
In bacterial oncotherapy, tumor-targeting bacteria deliver cytotoxins that induce cancer-cell apoptosis, requiring exogenous cues to induce such cytotoxins. We mined the part of the Escherichia coli genome regulating immunotoxin (anticancer...
XPO1 inhibitor KPT-330 disrupts the core transcriptional regulatory circuitry of dedifferentiated liposarcoma by modulating the translation process [0.03%]
XPO1抑制剂KPT-330通过调节翻译过程破坏去分化脂肪肉瘤的核心转录调控电路
Xiaorui Fan,Ying Zhang,Zhengming Yang et al.
Xiaorui Fan et al.
Dedifferentiated liposarcoma (DDLPS) is a rare and aggressive subtype of liposarcoma, driven by a core transcriptional regulatory circuitry (CRC) that sustains tumor proliferation. This malignancy poses considerable clinical challenges, mar...
Correction: The lncRNA THOR interacts with and stabilizes hnRNPD to promote cell proliferation and metastasis in breast cancer [0.03%]
关于长链非编码RNA THOR通过与hnRNPD互作促进乳腺癌细胞增殖和转移的纠正意见
Hongtao Hu,Hanqiu Zhang,Yue Xing et al.
Hongtao Hu et al.
Published Erratum
Oncogene. 2026 Apr 15. DOI:10.1038/s41388-026-03790-0 2026