FBXO28 suppresses liver cancer invasion and metastasis by promoting PKA-dependent SNAI2 degradation [0.03%]
FBXO28通过促进PKA依赖的SNAI2降解抑制肝癌侵袭和转移
Xinran Qiao,Jingyu Lin,Jiajia Shen et al.
Xinran Qiao et al.
FBXO28 is a member of F-box proteins that are the substrate receptors of SCF (SKP1, CULLIN1, F-box protein) ubiquitin ligase complexes. Despite the implications of its role in cancer, the function of FBXO28 in epithelial-mesenchymal transit...
A positive feedback between cholesterol synthesis and the pentose phosphate pathway rather than glycolysis promotes hepatocellular carcinoma [0.03%]
胆固醇合成与戊糖磷酸途径而非糖酵解之间的正反馈促进肝细胞癌的发展
Junjie Hu,Ningning Liu,David Song et al.
Junjie Hu et al.
Hepatic cholesterol accumulation and hypercholesterolemia are implicated in hepatocellular carcinoma (HCC). However, the therapeutic effects of cholesterol-lowering drugs on HCC are controversial, indicating that the relationship between ch...
AXL activates YAP through the EGFR-LATS1/2 axis and confers resistance to EGFR-targeted drugs in head and neck squamous cell carcinoma [0.03%]
AXL通过EGFR-LATS1/2轴活化YAP并在头颈鳞状细胞癌中赋予表皮生长因子受体靶向药物耐药性
Kento Okamoto,Toshinori Ando,Hiroki Izumi et al.
Kento Okamoto et al.
The Hippo signaling pathway and its downstream effector YAP play a central role in cell proliferation. Dysregulation of the Hippo pathway triggers YAP hyperactivation, thereby inducing head and neck squamous cell carcinoma (HNSCC). Recently...
ASCL2 induces an immune excluded microenvironment by activating cancer-associated fibroblasts in microsatellite stable colorectal cancer [0.03%]
ASCL2通过激活癌相关成纤维细胞在微卫星稳定型结直肠癌中诱导免疫排除型肿瘤微环境
Dan Zhang,Qi-Qi Ni,Qiao-Yan Liang et al.
Dan Zhang et al.
Proficient mismatch repair or microsatellite stable (pMMR/MSS) colorectal cancers (CRCs) are vastly outnumbered by deficient mismatch repair or microsatellite instability-high (dMMR/MSI-H) tumors and lack a response to immune checkpoint inh...
YAP governs cellular adaptation to perturbation of glutamine metabolism by regulating ATF4-mediated stress response [0.03%]
YAP通过调节ATF4介导的应激反应调控细胞对谷氨酰胺代谢紊乱的适应性
Minjoong Kim,Sunsook Hwang,Byungjoo Kim et al.
Minjoong Kim et al.
Proliferating cells have metabolic dependence on glutamine to fuel anabolic pathways and to refill the mitochondrial carbon pool. The Hippo pathway is essential for coordinating cell survival and growth with nutrient availability, but no mo...
Julio Buñay,Myriam Kossai,Christelle Damon-Soubeyrant et al.
Julio Buñay et al.
Increasing evidence points towards a causal link between exposure to persistent organic pollutants (POPs) with increased incidence and aggressivity of various cancers. Among these POPs, dioxin and PCB-153 are widely found in our environment...
Going circular: history, present, and future of circRNAs in cancer [0.03%]
循环往复：环形RNA（circRNA）在癌症中的过去、现在和未来
Giuseppina Pisignano,David C Michael,Tanvi H Visal et al.
Giuseppina Pisignano et al.
To date, thousands of highly abundant and conserved single-stranded RNA molecules shaped into ring structures (circRNAs) have been identified. CircRNAs are multifunctional molecules that have been shown to regulate gene expression transcrip...
Pathologists' first opinions on barriers and facilitators of computational pathology adoption in oncological pathology: an international study [0.03%]
病理学家首次就计算病理学在肿瘤病理学中应用的障碍和促进因素发表意见：一项国际研究
Julie E M Swillens,Iris D Nagtegaal,Sam Engels et al.
Julie E M Swillens et al.
Computational pathology (CPath) algorithms detect, segment or classify cancer in whole slide images, approaching or even exceeding the accuracy of pathologists. Challenges have to be overcome before these algorithms can be used in practice....
Klotho-beta attenuates Rab8a-mediated exosome regulation and promotes prostate cancer progression [0.03%]
KLHL18通过调节EXOC2促进前列腺癌转移
Tingyu Wu,Yanshuang Zhang,Qing Han et al.
Tingyu Wu et al.
Tumor-secreted exosomes have a wide range of effects on the growth, metastasis, and drug resistance of cancer cells. However, whether and how the molecular mechanisms that regulate the secretion of exosomes could affect tumor progression re...
FANCA deficiency promotes leukaemic progression by allowing the emergence of cells carrying oncogenic driver mutations [0.03%]
FANCA缺陷通过允许携带致癌驱动突变的细胞的出现来促进白血病进展
Patrycja Pawlikowska,Laure Delestré,Sebastian Gregoricchio et al.
Patrycja Pawlikowska et al.
Leukaemia is caused by the clonal evolution of a cell that accumulates mutations/genomic rearrangements, allowing unrestrained cell growth. However, recent identification of leukaemic mutations in the blood cells of healthy individuals reve...