Arginine methylation-dependent stabilization of SUV39H1 promotes breast cancer growth [0.03%]
精氨酰甲基化依赖的SUV39H1稳定促进乳腺癌生长
Wei Zhao,Ge Wang,Peng Wang et al.
Wei Zhao et al.
Suppressors of variegation 3-9 homolog 1 (SUV39H1), the enzyme responsible for establishing histone H3 lysine 9 trimethylation (H3K9me3) marks in heterochromatin, is frequently dysregulated in cancers. However, the mechanisms underlying SUV...
CHD1 is a synthetic lethal vulnerability in MYC-driven breast cancer [0.03%]
CHD1是MYC驱动的乳腺癌的人工合成致死脆弱点
Brandon Cho,Giacomo Furlan,Peter Lin et al.
Brandon Cho et al.
The MYC transcription factor is a key regulator of growth during development and a potent cancer driver when its expression is dysregulated. Strategies to inhibit MYC oncogenic activity would mark a significant advance, but decades of effor...
Dexamethasone promotes neutrophil ROS-mediated tumor killing through the glucocorticoid receptor [0.03%]
地塞米松通过糖皮质激素受体促进中性粒细胞ROS介导的肿瘤杀伤作用
Zhanhong Liu,Rongrong Sun,Yinghong Li et al.
Zhanhong Liu et al.
Glucocorticoids are frequently administered to alleviate therapy-related side effects in cancer patients, yet their role in tumor progression remains controversial and mechanistically unresolved. Here, we demonstrate that the long-acting gl...
C-Jun-activated S100A10 promotes malignant progression via in diminishing ubiquitin-dependent degradation of vimentin in gastric cancer [0.03%]
C-Jun激活的S100A10通过减少胃癌中波形蛋白的泛素依赖性降解促进恶性进展
Yan Li,Li-Xiang Li,Yin-He Sikong et al.
Yan Li et al.
Gastric cancer remains a significant global health challenge. Lymph node metastasis (LNM) has been identified to be relevant to the prognosis of gastric cancer (GC). However, its mechanisms of progression and metastasis are still not fully ...
PMM2 interacts with TRIM28 to recruit E2F4 and promote KIFC3-mediated tumor glycolysis and colorectal cancer progression [0.03%]
PMM2与TRIM28相互作用以招募E2F4并促进KIFC3介导的肿瘤糖酵解和结直肠癌进展
Zheng Peng,Bing Ma,Zhou Song et al.
Zheng Peng et al.
Colorectal cancer (CRC) remains a major global health burden with limited therapeutic options. This study identifies phosphomannomutase 2 (PMM2) as a key oncogenic driver in CRC. PMM2 is significantly upregulated in CRC tissues and cell lin...
KRAS-extrachromosomal DNA drives intratumoral heterogeneity in gastric cancer [0.03%]
胃癌中KRAS细胞外染色体DNA驱动瘤内异质性
Rong Guan,Chenxi Li,Xinchun Dai et al.
Rong Guan et al.
Extrachromosomal DNA (ecDNA), autonomously replicating circular DNA outside the chromosomes, exists as critical oncogene driver in approximately 20% of all tumors. Massive ecDNA amplification and its asymmetric segregation during mitotic dr...
Core fucosylation of NCEH1 by FUT8 promotes progression of high-grade serous ovarian cancer by driving tumor-associated macrophage M2 polarization [0.03%]
FUT8介导的NCEH1岩藻糖基化通过驱动M2型肿瘤相关巨噬细胞极化促进高级别浆液性卵巢癌进展
XiaoSong Pei,Fei Wang,Xiaomin Liu et al.
XiaoSong Pei et al.
High-grade serous ovarian cancer (HGSC) is the most aggressive subtype of ovarian epithelial cancer (OEC), with characters of late-stage diagnosis, high recurrence rate, and poor survival outcomes. Fucosyltransferase 8 (FUT8) is responsible...
ULK1 promotes metastatic progression in experimental models of epithelial ovarian cancer [0.03%]
ULK1在卵巢癌上皮细胞模型中促进癌症转移进展
Jack D Webb,Adrian Buensuceso,Emily J Tomas et al.
Jack D Webb et al.
Epithelial ovarian cancer (EOC) is a leading cause of gynecological cancer mortality, driven largely by late diagnosis and chemoresistance. While autophagy is critical for EOC spheroid survival during metastasis, the role of ULK1, a key reg...
Correction: Loss of DAB2IP in RCC cells enhances their growth and resistance to mTOR-targeted therapies [0.03%]
纠正：DAB2IP在RCC细胞中的丢失增强了其生长和对mTOR靶向治疗的抵抗性
J Zhou,J Luo,K Wu et al.
J Zhou et al.
Published Erratum
Oncogene. 2026 Mar 4. DOI:10.1038/s41388-026-03721-z 2026
Correction: Hippo signaling dysfunction induces cancer cell addiction to YAP [0.03%]
hippo信号功能障碍诱导癌细胞依赖于YAP
Han Han,Bing Yang,Hiroki J Nakaoka et al.
Han Han et al.
Published Erratum
Oncogene. 2026 Mar 4. DOI:10.1038/s41388-026-03719-7 2026