Editorial Expression of Concern: p53 promotes adenoviral replication and increases late viral gene expression [0.03%]
J A Royds,M Hibma,B R Dix et al.
J A Royds et al.
Crosstalk between integrin signaling and NAD⁺ biosynthetic pathways promotes glycolysis, proliferation, survival, and tumor growth in triple-negative breast cancer [0.03%]
Orion Spellecy,Javeria Qadir,Rongbo Han et al.
Orion Spellecy et al.
Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited therapeutic options. Here, we investigated how integrin-dependent signaling pathways regulate tumor metabolism and therapeutic vulnerability in TNBC. P...
MS4A4A promotes macrophages M2 polarization via NF-κB /JAK-STAT6 axis, resulting GBM malignant progression [0.03%]
Ziwei Li,Chunfa Wu,Zhongliang Cui et al.
Ziwei Li et al.
The immunosuppressive tumor microenvironment (TME) is a major issue in the malignant progression of glioma patients. The membrane spanning four domains A4A (MS4A4A) has a relationship with M2 polarization of macrophages, and participates in...
KDM4B/DHX9 promotes chemoresistance in small-cell lung cancer through the MYCN-driven signaling pathway [0.03%]
Qiong Lyu,Huiying Liu,Weitao Shen et al.
Qiong Lyu et al.
Small cell lung cancer (SCLC) is prone to developing chemoresistance, which is associated with epigenetic reprogramming. While LSD1-mediated histone demethylation has been reported, a systematic investigation into the role of histone demeth...
Olfactomedin 4 orchestrates TGF-β/CEACAM6 axis, promoting cell-autonomous epithelial to mesenchymal transition during gallbladder epithelium carcinogenesis [0.03%]
Songlin Yang,Wenwen Huang,Qingju Zeng et al.
Songlin Yang et al.
Gallbladder cancer (GBC) is a highly lethal disease which is usually diagnosed at advanced stage owing to unavailable screening tools and effective therapies. Persistent inflammation induced by various risk factors is the main cause of GBC,...
Rapid activation of ARF6 after RAF inhibition augments BRAFV600E and promotes therapy resistance [0.03%]
Junhua Wang,Yinshen Wee,Thomas Jacob et al.
Junhua Wang et al.
The intrinsic ability of cancer cells to evade death underpins tumorigenesis, progression, metastasis, and the survival of drug-tolerant persister (DTP) cells. Herein, we discovered that the small GTPase ARF6 plays a central role in tumor s...
Richard Demmler,Charles G Anchang,Yongsong Yong et al.
Richard Demmler et al.
Colorectal cancer (CRC) is one of the most commonly diagnosed and globally spread malignant diseases. Cancer-associated fibroblasts (CAFs) are key architects of the tumor microenvironment, yet their origin, stability, and interconvertibilit...
METTL1-mediated m7G modification of ASNS mRNA regulates asparagine metabolism reprogramming to promote hepatocellular carcinoma progression [0.03%]
Huiwu Xing,Fuqiang Ma,Penghui Li et al.
Huiwu Xing et al.
Hepatocellular carcinoma (HCC) is a prevalent and aggressive malignancy, notorious for its high recurrence, substantial drug resistance, and poor prognosis. Although METTL1, a key regulator of RNA m7G modification, is implicated in the prog...
Modulating gut microbiota to enhance anti-PD-1/PD-L1 immunotherapy in hepatocellular carcinoma: the role of Lactobacillus kefiranofaciens and SOCS3 regulation [0.03%]
Caihong Lv,Junli Du,Wanqing Feng et al.
Caihong Lv et al.
Immunotherapy targeting the programmed cell death-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) (PD-1/PD-L1) axis has revolutionized cancer treatment, yet its efficacy in hepatocellular carcinoma (HCC) remains limited. Emerging evidence s...
Hiroki Hayashida,Yosuke Masamoto,Takashi Oyama et al.
Hiroki Hayashida et al.
Ecotropic viral integration site 1 (EVI1) is essential for hematopoietic stem cell maintenance, and its aberrant expression is a significant adverse prognostic indicator in myeloid leukemia. EVI1 overexpression typically occurs due to chrom...