Therapeutic benefit of the dual ALK/FAK inhibitor ESK440 in ALK-driven neuroblastoma [0.03%]
ALK驱动的神经母细胞瘤中双ALK/FAK抑制剂ESK440的治疗益处
Seema Chugh,Jean C Tien,Jennifer Hon et al.
Seema Chugh et al.
Neuroblastoma (NB) is a predominantly pediatric cancer with greater than 90% of cases arising in children under the age of five. More than half of patients have metastases detected at diagnosis, and high-risk disease is associated with five...
Acquired vulnerability against EGF receptor inhibition in gastric cancer promoted by class I histone deacetylase inhibitor entinostat [0.03%]
胃癌中由第I类组蛋白脱乙酰基酶抑制剂entinostat促进的对表皮生长因子受体抑制的获得性抵抗性
Tamara Zenz,Robert Jenke,Denys Oliinyk et al.
Tamara Zenz et al.
Introduction: Histone deacetylase inhibitors (HDACi) have shown promising preclinical activity in gastric cancer cells; unfortunately, however, these could not be confirmed in clinical trials. This highlights the need for...
The chemokine CX3CL1 promotes intraperitoneal tumour growth despite enhanced T-cell recruitment in ovarian cancer [0.03%]
趋化因子CX3CL1通过增强T细胞募集促进卵巢癌腹腔内肿瘤生长
Stefanie Seitz,Tobias F Dreyer,Christoph Stange et al.
Stefanie Seitz et al.
T-cell recruiting chemokines are required for a successful immune intervention in ovarian cancer, and also for the efficacy of modern anticancer agents such as PARP inhibitors. The chemokine CX3CL1 recruits tumour-suppressive T-cells into s...
Global, regional and national burden of neuroblastoma and other peripheral nervous system tumors, 1990 to 2021 and predictions to 2035: visualizing epidemiological characteristics based on GBD 2021 [0.03%]
基于GBD 2021的神经母细胞瘤和其他周围神经系统肿瘤全球、区域和国家负担（1990年至2021年）及预测（至2035年）：可视化流行病学特征
Chaoyan Yue,Qi Zhang,Fenyong Sun et al.
Chaoyan Yue et al.
Background: Neuroblastoma (NB) is the most common extracranial malignant solid tumor in children, accounting for >15 % of cancer-related deaths in children. We analyzed the epidemiological statistical indicators of neurob...
True cancer stem cells exhibit relative degrees of dormancy and genomic stability [0.03%]
真正的癌症干细胞表现出不同程度的休眠和基因组稳定性
Sanford H Barsky,Krista Mcphail,Justin Wang et al.
Sanford H Barsky et al.
Background: Cancer stem cells in human tumors have been defined by stem cell markers, embryonal signaling pathways and characteristic biology, ie., namely the ability to repopulate the proliferating population. However, e...
Informatics strategies for early detection and risk mitigation in pancreatic cancer patients [0.03%]
胰腺癌患者的早期检测和风险缓解的信息策略
Di Jin,Najeeb Ullah Khan,Wei Gu et al.
Di Jin et al.
This review provides a comprehensive overview of the current landscape in pancreatic cancer (PC) screening, diagnosis, and early detection. This emphasizes the need for targeted screening in high-risk groups, particularly those with familia...
Pancreatic cancer cells infiltrate nerves through TGFbeta1-driven perineural epithelial-to-mesenchymal-like transdifferentiation [0.03%]
TGFβ1驱动的癌细胞上皮间质转化可使胰腺癌细胞侵入神经血管系统
Theresa Krauss,Ibrahim Halil Gürcinar,Ulrike Bourquain et al.
Theresa Krauss et al.
Neural invasion is a prognostic hallmark of pancreatic ductal adenocarcinoma (PDAC), yet the underlying mechanisms behind the disruption of perineural barriers and access of cancer cells into intrapancreatic nerves remain poorly understood....
Ryan M Thomas
Ryan M Thomas
Research elucidating the role of the microbiome in carcinogenesis has grown exponentially over the past decade. Initially isolated to associative studies on colon cancer development, the field has expanded to encompass nearly every solid an...
Corrigendum to "Depletion of ß1,6-N-acetylglucosaminyltransferase reduces E-selectin binding capacity and migratory potential of human gastrointestinal adenocarcinoma cells" [Neoplasia 59 (2024) 10183] [0.03%]
关于“β1,6-N-乙酰氨基葡萄糖转移酶的耗竭降低了人类胃肠道腺癌细胞与E-选择素的结合能力和迁移潜力”的勘误声明 [Neoplasia 59 (2024) 10183]
Lisa Staffeldt,Hanna Maar,Julia Beimdiek et al.
Lisa Staffeldt et al.
Published Erratum
Neoplasia (New York, N.Y.). 2025 Jan 17:60:101124. DOI:10.1016/j.neo.2025.101124 2025
Spatial profiling of endoplasmic reticulum stress markers in tumor associated cells predicts patient outcomes in pancreatic cancer [0.03%]
胰腺癌相关细胞的内质网应激标志物空间分析可预测患者预后
Georgia Porter,Murray D Norris,Minoti Apte et al.
Georgia Porter et al.
Introduction: The impact of endoplasmic reticulum (ER) stress in tumor-associated cells, such as cancer associated fibroblasts (CAFs), immune cells and endothelial cells, on patient outcomes in clinical specimens have not...