mTOR inhibition augments antitumor immune effector response by reprogramming the TP53-mutant, immune-cold HNSCC tumor microenvironment [0.03%]
哺乳动物目标雷帕霉素(mTOR)抑制通过重新编程TP53突变型、免疫抑制性头颈肿瘤微环境来增强抗肿瘤免疫反应
Priyatosh Nath,Alok Khandelwal,Chun Li et al.
Priyatosh Nath et al.
Resistance to immunotherapy remains a major clinical challenge in TP53-mutant head and neck squamous cell carcinoma (HNSCC), a disease subset characterized by immune exclusion, high recurrence, and poor outcomes. Given the constitutive acti...
EZH1/2 inhibition selectively targets SMARCA4/2 co-deficient lung cancer cells by suppressing stemness and proliferation [0.03%]
EZH1/2抑制通过抑制干细胞特性和增殖选择性靶向SMARCA4/2共缺失的肺癌细胞
Jeongjae Lee,Jaeik Oh,Soyeon Kim et al.
Jeongjae Lee et al.
SMARCA4-deficient thoracic malignancies comprise biologically heterogeneous tumors, ranging from conventional non-small cell lung cancer with SMARCA4 alterations to thoracic SMARCA4-deficient undifferentiated tumor (SMARCA4-UT), an aggressi...
Prophylactic folinic acid prevents pemetrexed myelosuppression: A randomized trial toward safer treatment with chemotherapy in non-small cell lung cancer [0.03%]
预防性使用亚叶酸钙可防止培美曲塞引起的骨髓抑制：一项有关非小细胞肺癌化疗安全性的随机试验
Ramon Contrucci,Rob Ter Heine,Merel Tonn et al.
Ramon Contrucci et al.
Background Pemetrexed is a cornerstone in advanced non-small cell lung cancer treatment. Although generally well tolerated, severe myelosuppression occurs in 26% of patients. Preventing chemotherapy-associated toxicity has become increasing...
Foretinib triggers immunogenic cell death and enhances efficacy of anti-CD47 immunotherapy in colorectal cancer [0.03%]
Foretinib诱导免疫原性细胞死亡并增强抗CD47免疫治疗在结直肠癌中的疗效
Lin Li,Nannan Zhu,Tao Zhu et al.
Lin Li et al.
Dual-target c-Met/VEGFR kinase inhibitors have emerged as promising therapeutic agents for cancer therapy, although their underlying antitumor mechanisms remain poorly defined. In this study, we demonstrate that foretinib, a selective c-Met...
Cosmc loss induces truncated O-glycosylation and accelerates Kras-driven pancreatic carcinogenesis [0.03%]
宇宙辐射诱发的截短型O-糖基化加速Kras驱动的胰腺癌发生
Baris Mercanoglu,Nina Schraps,Anastasios D Giannou et al.
Baris Mercanoglu et al.
Aberrant mucin-type O-glycosylation is a common feature of pancreatic ductal adenocarcinoma (PDAC), yet its functional contribution to pancreatic tumorigenesis remains incompletely defined. In particular, whether defective core 1 O-glycan m...
Glycan targeting can recruit anti-tumor immunologic functions by lymphatic endothelium [0.03%]
糖链靶向可招募淋巴内皮的抗肿瘤免疫功能
Aditya Dash,Scott C Johns,Chace Moleta et al.
Aditya Dash et al.
During carcinoma progression, CD8+ T cells mediate tumor-cytolytic functions following tumor-antigen sensitization, typically by antigen cross-presenting dendritic cells. Lymphatic endothelial cells (LECs) are not typically endowed with suc...
Developmentally constrained plasticity as a therapeutic vulnerability in cancer [0.03%]
发育限制的可塑性作为癌症治疗的弱点
Jie-Shen Xian,Yuan-Xiang Yang,Wei-Ling Li et al.
Jie-Shen Xian et al.
Cancer cells can exploit developmental lineage programs to generate phenotypic heterogeneity under therapeutic pressure. Although a subset of resistant tumors preserves its founding lineage, receptor, or oncogenic dependency, accumulating e...
Epigenetic memory of inflammation as a driver of cancer risk: insights from Colitis [0.03%]
炎症的表观遗传记忆作为癌症风险驱动因素：结肠炎研究中的见解
Alok K Mishra,Umar Khalid Khan,Bushra Ateeq
Alok K Mishra
Chronic inflammation increases cancer risk, yet the mechanisms linking transient injury to long-term susceptibility remain elusive. Nagaraja et al [1] demonstrate that intestinal stem cells retain durable epigenetic memory of colitis, there...
Alwine B Kruisselbrink,Tessa A H Wilpshaar,Ieva Palubeckaitė et al.
Alwine B Kruisselbrink et al.
Introduction: Synthetic lethal interactions with IDH1 and IDH2 (IDH) mutations were identified in non-endogenous IDH mutant (IDHMUT) AML and glioma models, but are absent in endogenous IDHMUT chondrosarcoma cell lines. Th...
CLCF1-ZIC5-CNTFR feedback loop drives cisplatin resistance in cervical squamous cell carcinoma [0.03%]
CLCF1-ZIC5-CNTFR反馈回路驱动宫颈鳞癌细胞顺铂耐药性
Qingge Jia,Mingyang Li,Jin Liu et al.
Qingge Jia et al.
Cervical squamous cell carcinoma (CESC) is frequently complicated by cisplatin (CDDP) resistance, which is a primary cause of treatment failure and poor prognosis. Here, we identified a CLCF1-ZIC5-CNTFR feedback loop that contributes to CDD...