Metabolic regulation of histone acetylation by ACLY supports MDR1 expression in colorectal cancer and highlights a targetable vulnerability [0.03%]
ACLY代谢调控组蛋白乙酰化以支持结直肠癌中MDR1的表达并提示一种可靶向的弱点
Ana García-Bautista,Aiora Cenigaonandia-Campillo,Anxo Rio-Vilariño et al.
Ana García-Bautista et al.
Chemoresistance remains a major cause of treatment failure in colorectal cancer (CRC), yet the metabolic mechanisms sustaining efflux-mediated drug resistance are not fully defined. Here, we identify ATP-citrate lyase (ACLY) as a metabolic ...
Pancreatic metastases are suppressed by photodynamic therapy and irinotecan through macrophage reprogramming in immunodeficient mice [0.03%]
缺损小鼠的光动力疗法和伊立替康通过巨噬细胞重编来抑制胰腺转移病灶
Fernanda V Cabral,Jose Quilez-Alburquerque,Olivia Mooradian et al.
Fernanda V Cabral et al.
Pancreatic ductal adenocarcinoma (PDAC) exhibits early metastatic dissemination, dense desmoplastic stroma, and significant resistance to therapy. Our previous studies have shown that photodynamic therapy (PDT) combined with chemotherapy re...
Corrigendum to: The SRSF3-MBNL1-Acin1 circuit constitutes an emerging axis to lessen DNA fragmentation in colorectal cancer via an alternative splicing mechanism [0.03%]
关于SRSF3-MBNL1-Acin1电路通过可变剪接机制降低结直肠癌DNA片段化的新兴轴的更正注释文章
Yi-Su Chen,Chao-Wei Liu,Ying-Chin Lin et al.
Yi-Su Chen et al.
Published Erratum
Neoplasia (New York, N.Y.). 2026 Apr 29:77:101313. DOI:10.1016/j.neo.2026.101313 2026
Molecular landscape and clinical translation of DNA damage response alterations in solid tumors: A pan-cancer perspective on precision oncology [0.03%]
DNA损伤反应改变在实体肿瘤中的分子图谱及其临床转化：关于精确肿瘤治疗的泛癌视角
Haixia Zhu,Jingjing Shao,Yaxuan Wang et al.
Haixia Zhu et al.
DNA damage response (DDR) pathways are essential for maintaining genomic integrity. Accumulating pan-cancer evidence, however, reveals that alterations within these networks act as widespread drivers of tumor initiation, progression, and th...
Ataxia telangiectasia mutated (ATM) kinase as a predictive biomarker in clinical oncology: implications for a precision treatment approach [0.03%]
ATM激酶作为临床肿瘤学中的预测性生物标志物：精准治疗的启示
Ann T Pham,Fenghua Yuan,Nagaraj S Nagathihalli et al.
Ann T Pham et al.
ATM (ataxia telangiectasia mutated) kinase is a central mediator of the DNA damage response (DDR), with established roles in maintaining genomic integrity in response to genotoxic insults. Both germline and somatic alterations in ATM occur ...
From inflammation to malignancy: the dynamic evolution of cancer-associated fibroblasts in IBD-CRC [0.03%]
从炎症到恶性：IBD-CRC中癌相关成纤维细胞的动态演变
Nobuhiro Naito,Hiroaki Kasashima,Tatsunari Fukuoka et al.
Nobuhiro Naito et al.
Inflammatory bowel disease-associated colorectal cancer (IBD-CRC) represents a distinct clinical and molecular entity characterized by long-standing inflammation and a unique "dysplasia-carcinoma" sequence. While epithelial genetic alterati...
A MYC family switch: L-MYC drives and maintains neuroendocrine lineage programs in prostate cancer [0.03%]
前列腺癌中的MYC家族调控开关：L-MYC驱动和维持神经内分泌谱系程序
Jeyaluxmy Sivalingam,Kaleigh Ballagh,Kyung Hyun Cho et al.
Jeyaluxmy Sivalingam et al.
Neuroendocrine prostate cancer (NEPC) is an aggressive, therapy-resistant subtype that emerges through lineage plasticity following androgen receptor pathway inhibition. Although MYC family oncogenes are central to prostate cancer progressi...
Characterizing the impact of MLL fusion variants and fusion partners on leukemia plasticity using a human CRISPR-engineered MLL-rearranged leukemia model [0.03%]
利用人类CRISPR工程MLL重排白血病模型表征MLL融合变体和融合伴侣对白血病可塑性的影响
Pia Radszuweit,Rahel Fitzel,Sarah Bruestl et al.
Pia Radszuweit et al.
Acute leukemias involving KMT2A (MLL) rearrangements are aggressive hematologic malignancies associated with a poor prognosis, especially in infants. The majority of MLL breakpoints are located within the breakpoint cluster region spanning ...
PIK3CA mutant cervical cancer is selectively suppressed by PI3Kα inhibition (Alpelisib/BYL-719 and Inavolisib/GDC-0077) and cooperates with HPV directed T cell therapy [0.03%]
PIK3CA突变型宫颈癌通过PI3Kα抑制（阿培利塞/拜乐-719和吲那福韦司普/吉迪尼77）被选择性抑制，并与HPV导向的T细胞疗法协同作用
Hong Lou,David Langan,Nick Syracuse et al.
Hong Lou et al.
Cervical cancer is largely driven by human papillomavirus (HPV) infection, yet clinically actionable molecular subtypes and effective targeted therapies remain limited. Here, we define biologically and clinically relevant subtypes and evalu...
Assessing axitinib-induced differential responses in tumor vascularization and oxygenation with combined optoacoustic angiography and diffuse optical spectroscopy [0.03%]
结合光声血管造影和扩散光学监测阿西替尼治疗后肿瘤血管化和氧合的差异响应评估
Anna Orlova,Ksenia Akhmedzhanova,Anna Glyavina et al.
Anna Orlova et al.
Efficacy of antiangiogenic treatments is often linked to the complex interplay between tumor vascularization and oxygenation. Yet their relationship remains difficult to assess in vivo due to limitations of conventional clinical imaging tec...