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Establishing a comprehensive panel of patient-derived xenograft models for high-grade endometrial carcinoma: molecular subtypes, genetic alterations, and therapeutic target profiling [0.03%] 建立高分级子宫内膜癌患者来源异种移植模型的全面谱系：分子亚型、遗传改变及治疗靶标分析
Sho Sato,Shigehiro Yagishita,Hiroshi Yoshida et al. Sho Sato et al.
Background: High-grade endometrial cancer (EC) has a poor prognosis, but molecular classification-based treatments present new therapeutic opportunities. Antibody-drug conjugates (ADC) emerge as promising tools, yet a dee...
Systemic inflammation in response to radiation drives the genesis of an immunosuppressed tumor microenvironment [0.03%] 辐射诱发的全身性炎症促进免疫抑制型肿瘤微环境的形成
Lin Ma,Jian-Hua Mao,Mary Helen Barcellos-Hoff Lin Ma
The composition of the tumor immune microenvironment has become a major determinant of response to therapy, particularly immunotherapy. Clinically, a tumor microenvironment lacking lymphocytes, so-called "cold" tumors, are considered poor c...
L-methionine promotes CD8+ T cells killing hepatocellular carcinoma by inhibiting NR1I2/PCSK9 signaling [0.03%] L-甲硫氨酸通过抑制NR1I2 / PCSK9信号促进CD8 + T细胞杀伤肝癌
Chengsha Yuan,Changpeng Hu,Huyue Zhou et al. Chengsha Yuan et al.
Background: Liver cancer has consistently high incidence and mortality rates among malignant tumors. PCSK9, a target for hypercholesterolemia therapy, has recently been identified as an inhibitor of anti-tumor immunity, a...
High dose acetaminophen re-polarizes CD11b+ cells in the tumor microenvironment towards an activated macrophage phenotype [0.03%] 高剂量对乙酰氨基酚使肿瘤微环境中的CD11b+细胞重新极化为活化的巨噬细胞表型
Allyn Bryan,Madison Isbell,Pavani Pingali et al. Allyn Bryan et al.
Objective: High dose acetaminophen (AAP) has demonstrated promising results in early phase clinical trials for treatment of advanced malignancies. When administered concurrently with the CYP2E1 inhibitor fomepizole, AAP c...
MTFR1 phosphorylation-activated adaptive mitochondrial fusion is essential for colon cancer cell survival during glucose deprivation [0.03%] 葡萄糖剥夺期间MTFR1磷酸化激活的适应性线粒体融合对结肠癌细胞生存至关重要
Nan Zhang,Lu Dong,Sifan Liu et al. Nan Zhang et al.
Background: Mitochondrial dynamics are essential for maintaining cellular function under metabolic stress. However, their role in colon cancer's response to glucose deprivation remains poorly understood. ...
Comprehensive mapping elucidates high risk genotypes in primary metastatic breast cancer [0.03%] 全面绘制揭示原发转移性乳腺癌中的高风险基因型
Tobias Berg,Lise Ahlborn,Maj-Britt Jensen et al. Tobias Berg et al.
Among women with primary metastatic breast cancer (pMBC), around 5 % of women with primary invasive breast cancer, high-risk mutations associated with disease progression and poor prognosis is shown. The heterogeneity and clinical implicati...
Expression of the cholesterol transporter SR-B1 in melanoma cells facilitates inflammatory signaling leading to reduced cholesterol synthesis [0.03%] 胆固醇转运蛋白SR-B1在黑色素瘤细胞中的表达促进炎症信号传导，导致胆固醇合成降低
Oliver Eckel,Madalina A Mirea,Anna Gschwendtner et al. Oliver Eckel et al.
Scavenger receptor class B type 1 (SR-B1) is a cholesterol transporter, abundantly expressed in human melanoma, yet its precise role for melanoma progression is not fully understood. This study investigates the involvement of SR-B1 in chole...
Anti-PD1 prolongs the response of PI3K and farnesyl transferase inhibition in HRAS- and PIK3CA-mutant head and neck cancers [0.03%] 抗PD1延长了HRAS和PIK3CA突变的头颈癌对PI3K和牻牛儿基转移酶抑制的反应时间
Dinesh Babu Manikandan,Sankar Jagadeeshan,Sooraj Mathukkada et al. Dinesh Babu Manikandan et al.
Background: Tipifarnib, a farnesyl transferase inhibitor, has shown promising response in the treatment of HRAS-mutant HNSCC in the clinic, and in combination with a PI3K inhibitor in PIK3CA-mutant mouse models; however, ...
Kv11.1-dependent senescence activates a lethal immune response via tumor necrosis factor alpha [0.03%] 依赖Kv11.1的衰老通过肿瘤坏死因子α激活致命免疫反应
Maedeh Vakili Saatloo,Davide Delisi,Najmeh Eskandari et al. Maedeh Vakili Saatloo et al.
Understanding the complex relationship between cancer and immune surveillance is essential for leveraging the immune system to control tumor growth. In our study, we discovered that activating the Kv11.1 potassium channel in ER+ breast canc...
Targeting BARD1 suppresses a Myc-dependent transcriptional program and tumor growth in pancreatic ductal adenocarcinoma [0.03%] BARD1在胰腺导管腺癌中抑制Myc依赖的转录程序和肿瘤生长
Sohum Patel,Eleanor Jenkins,Rutuj P Kusurkar et al. Sohum Patel et al.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers demanding better and more effective therapies. BARD1 or BRCA1-Associated -Ring Domain-1 plays a pivotal role in homologous recombination repair (HRR). However, its...