O-GlcNAc-modified HOXA9 suppresses ferroptosis via promoting UBR5-mediated SIRT6 degradation in nasopharyngeal carcinoma [0.03%]
O-GlcNAc修饰的HOXA9通过促进UBR5介导的SIRT6降解来抑制鼻咽癌的铁死亡
Huai Liu,Yingzhou Fu,Ling Tang et al.
Huai Liu et al.
Background: Nasopharyngeal carcinoma (NPC) is the most common malignancy of the nasopharynx. Ferroptosis induction shows anti-tumor activities in cancers including NPC. Elucidating the regulatory mechanism of ferroptosis ...
HRP2 regulating MICU1-mediated Ca2+ overload to dictate chemoresistance of multiple myeloma [0.03%]
HRP2调节MICU1介导的钙超载以决定多发性骨髓瘤的化疗抗性
Qian Li,Ziyi Peng,Li Lin et al.
Qian Li et al.
Despite the efficacy of bortezomib (BTZ)-based chemotherapy in treating multiple myeloma (MM) patients, chemoresistance occurs frequently over time, particularly in individuals exhibiting an initial positive response to BTZ therapy. In this...
Combining the RCAS/tv-a retrovirus and CRISPR/Cas9 gene editing systems to generate primary mouse models of diffuse midline glioma [0.03%]
结合使用RCAS/tv-a逆转病毒和CRISPR/Cas9基因编辑系统生成弥漫性中线胶质瘤的小鼠原发模型
Sophie R Wu,Julianne Sharpe,Joshua Tolliver et al.
Sophie R Wu et al.
Diffuse midline gliomas (DMGs) are lethal brain tumors that arise in children and young adults, resulting in a median survival of less than two years. Genetically engineered mouse models (GEMMs) are critical to studying tumorigenesis and tu...
Expression, regulation, function and clinical significance of B7-H6 on neutrophils in human gastric cancer [0.03%]
中性粒细胞B7-H6的表达、调节、功能及其在胃癌中的临床意义
Pan Wang,Peng Zhu,Zheng-Yan Li et al.
Pan Wang et al.
Neutrophils are conspicuous components of gastric cancer (GC) tumors, increasing with tumor progression and poor patient survival. However, the phenotype, regulation, function and clinical relevance of neutrophils in human GC are presently ...
John S Wang,Samuel J Schellenberg,Athena Demeros et al.
John S Wang et al.
Exosomes are extracellular vehicles that facilitate intra-cellular communication via transport of critical proteins and genetic material. Every exosome is intrinsically reflective of the cell from which it was derived and can even mimic eff...
Sialylated IgG-activated integrin β4-Src-Erk axis stabilizes c-Myc in a p300 lysine acetyltransferase-dependent manner to promote colorectal cancer liver metastasis [0.03%]
唾液酸化的IgG激活整合素β4-Src-Erk轴以p300赖氨酸乙酰转移酶依赖性的方式稳定c-Myc以促进结直肠癌肝转移
Jing Chen,Shenghua Zhang,Xinmei Huang et al.
Jing Chen et al.
Background: Liver metastasis is a leading cause of colorectal cancer mortality. Therefore, the underlying mechanism and potential therapeutic target of colorectal cancer liver metastasis urge to be found. Mounting evidenc...
Exogenous BMI1 expression aggravates oral squamous cell carcinomas in tongue epithelia [0.03%]
外源性BMI1表达加重舌上皮口腔鳞状细胞癌
Jorge Baquero,Xiao-Han Tang,Daniel Galke et al.
Jorge Baquero et al.
Oral squamous cell carcinoma (OSCC) is characterized by aggressiveness and a poor prognosis, in part because most patients are diagnosed during the later stages of the disease. B cell-specific Moloney murine leukemia virus integration site ...
Fatty acid synthase (FASN) inhibition cooperates with BH3 mimetic drugs to overcome resistance to mitochondrial apoptosis in pancreatic cancer [0.03%]
脂肪酸合成酶(FASN)抑制剂与BH3模拟药物联合使用可克服胰腺癌中对线粒体介导的凋亡的抵抗性
Travis Vander Steen,Ingrid Espinoza,Cristina Duran et al.
Travis Vander Steen et al.
Resistance to mitochondrial apoptosis is a major driver of chemoresistance in pancreatic ductal adenocarcinoma (PDAC). However, pharmacological manipulation of the mitochondrial apoptosis threshold in PDAC cells remains an unmet therapeutic...
m6A eraser ALKBH5/treRNA1/DDX46 axis regulates BCR expression [0.03%]
m6A擦除器ALKBH5/treRNA1/DDX46轴调节BCR表达
Bandish Kapadia,Anirban Roychowdhury,Forum Kayastha et al.
Bandish Kapadia et al.
Epitranscriptomic modifications, particularly N6-methyladenosine (m6A), have emerged as critical regulators of RNA stability, localization, and translation, shaping immune responses and tumor progression. In B-cell biology, m6A modification...
Effect of MisMatch repair deficiency on metastasis occurrence in a syngeneic mouse model [0.03%]
错配修复缺陷在同基因小鼠模型中对转移发生的影响
Pierre Laplante,Reginaldo Rosa,Laetitia Nebot-Bral et al.
Pierre Laplante et al.
Mismatch repair deficiency leads to high mutation rates and microsatellite instability (MSI-H), associated with immune infiltration and responsiveness to immunotherapies. In early stages, MSI-H tumors generally have a better prognosis and l...