High dose acetaminophen re-polarizes CD11b+ cells in the tumor microenvironment towards an activated macrophage phenotype [0.03%]
高剂量对乙酰氨基酚使肿瘤微环境中的CD11b+细胞重新极化为活化的巨噬细胞表型
Allyn Bryan,Madison Isbell,Pavani Pingali et al.
Allyn Bryan et al.
Objective: High dose acetaminophen (AAP) has demonstrated promising results in early phase clinical trials for treatment of advanced malignancies. When administered concurrently with the CYP2E1 inhibitor fomepizole, AAP c...
MTFR1 phosphorylation-activated adaptive mitochondrial fusion is essential for colon cancer cell survival during glucose deprivation [0.03%]
葡萄糖剥夺期间MTFR1磷酸化激活的适应性线粒体融合对结肠癌细胞生存至关重要
Nan Zhang,Lu Dong,Sifan Liu et al.
Nan Zhang et al.
Background: Mitochondrial dynamics are essential for maintaining cellular function under metabolic stress. However, their role in colon cancer's response to glucose deprivation remains poorly understood. ...
Comprehensive mapping elucidates high risk genotypes in primary metastatic breast cancer [0.03%]
全面绘制揭示原发转移性乳腺癌中的高风险基因型
Tobias Berg,Lise Ahlborn,Maj-Britt Jensen et al.
Tobias Berg et al.
Among women with primary metastatic breast cancer (pMBC), around 5 % of women with primary invasive breast cancer, high-risk mutations associated with disease progression and poor prognosis is shown. The heterogeneity and clinical implicati...
Expression of the cholesterol transporter SR-B1 in melanoma cells facilitates inflammatory signaling leading to reduced cholesterol synthesis [0.03%]
胆固醇转运蛋白SR-B1在黑色素瘤细胞中的表达促进炎症信号传导，导致胆固醇合成降低
Oliver Eckel,Madalina A Mirea,Anna Gschwendtner et al.
Oliver Eckel et al.
Scavenger receptor class B type 1 (SR-B1) is a cholesterol transporter, abundantly expressed in human melanoma, yet its precise role for melanoma progression is not fully understood. This study investigates the involvement of SR-B1 in chole...
Anti-PD1 prolongs the response of PI3K and farnesyl transferase inhibition in HRAS- and PIK3CA-mutant head and neck cancers [0.03%]
抗PD1延长了HRAS和PIK3CA突变的头颈癌对PI3K和牻牛儿基转移酶抑制的反应时间
Dinesh Babu Manikandan,Sankar Jagadeeshan,Sooraj Mathukkada et al.
Dinesh Babu Manikandan et al.
Background: Tipifarnib, a farnesyl transferase inhibitor, has shown promising response in the treatment of HRAS-mutant HNSCC in the clinic, and in combination with a PI3K inhibitor in PIK3CA-mutant mouse models; however, ...
Kv11.1-dependent senescence activates a lethal immune response via tumor necrosis factor alpha [0.03%]
依赖Kv11.1的衰老通过肿瘤坏死因子α激活致命免疫反应
Maedeh Vakili Saatloo,Davide Delisi,Najmeh Eskandari et al.
Maedeh Vakili Saatloo et al.
Understanding the complex relationship between cancer and immune surveillance is essential for leveraging the immune system to control tumor growth. In our study, we discovered that activating the Kv11.1 potassium channel in ER+ breast canc...
Targeting BARD1 suppresses a Myc-dependent transcriptional program and tumor growth in pancreatic ductal adenocarcinoma [0.03%]
BARD1在胰腺导管腺癌中抑制Myc依赖的转录程序和肿瘤生长
Sohum Patel,Eleanor Jenkins,Rutuj P Kusurkar et al.
Sohum Patel et al.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers demanding better and more effective therapies. BARD1 or BRCA1-Associated -Ring Domain-1 plays a pivotal role in homologous recombination repair (HRR). However, its...
Granulocyte-macrophage colony-stimulating factor for newly diagnosed glioblastoma [0.03%]
粒细胞巨噬细胞集落刺激因子用于新诊断的胶质母细胞瘤治疗
Caineng Cao,Le Wang,Feng Jiang et al.
Caineng Cao et al.
Background: There is a clear need to improve the efficiency of therapeutic strategy for patients with newly diagnosed glioblastoma (GBM). The purpose of this study was to evaluate the feasibility of hypofractionated inten...
Anbarasu Kumaraswamy,Rahul Mannan,Olivia A Swaim et al.
Anbarasu Kumaraswamy et al.
Background: Lysine-specific demethylase 1 (LSD1) is a histone demethylase and regulator of differentiation, including in cancer. A neuronal-specific isoform of LSD1-LSD1+8a-has been shown to play a key role in promoting n...
Targeting PAR1 activation in JAK2V617F-driven philadelphia-negative myeloproliferative neoplasms: Unraveling its role in thrombosis and disease progression [0.03%]
靶向JAK2V617F驱动的费城染色体阴性髓系增生性肿瘤中的PAR1激活：揭示其在血栓形成和疾病进展中的作用
İldeniz Uslu-Biçak,Meliha Nalçaci,Selçuk Sözer
İldeniz Uslu-Biçak
Philadelphia chromosome-negative myeloproliferative neoplasms (Ph-MPNs) are clonal disorders marked by high morbidity and mortality, driven by uncontrolled myeloid proliferation from hematopoietic stem/progenitor cells (HSCs) and associated...