High metastatic tumor-derived CXCL16 mediates liver colonization metastasis by inducing Kupffer cell polarization via the PI3K/AKT/FOXO3a pathway [0.03%]
高转移瘤来源的CXCL16通过PI3K/AKT/FOXO3a信号诱导库普弗细胞极化介导肝转移种植
Yin Liu,Yunpeng Zhai,Yi Zhang et al.
Yin Liu et al.
Liver metastases represent a late-stage manifestation of numerous cancers, often associated with poor patient prognosis. Kupffer cells (KCs), resident liver macrophages, play a critical role in liver metastasis (LM). However, the mechanisms...
Corrigendum to "Antitumor Action of a Novel Histone Deacetylase Inhibitor, YF479, in Breast Cancer" [Neoplasia. 2014 Aug;16(8):665-77] [0.03%]
“新型组蛋白脱乙酰酶抑制剂YF479的抗肿瘤作用”一文的勘误页[Neoplasia. 2014 Aug;16(8):665-77]
Tao Zhang,Yihua Chen,Jingjie Li et al.
Tao Zhang et al.
Published Erratum
Neoplasia (New York, N.Y.). 2025 May 8:65:101168. DOI:10.1016/j.neo.2025.101168 2025
Establishment of patient-derived 3D in vitro models of sarcomas: literature review and guidelines on behalf of the FORTRESS working group [0.03%]
基于FORTRESS工作组的文献回顾建立软组织肉瘤患者来源的体外三维模型及指导意见
Lore De Cock,Ieva Palubeckaitė,Francesca Bersani et al.
Lore De Cock et al.
Sarcomas are a large family of rare and heterogeneous mesenchymal tumors, which respond poorly to available systemic treatments. Translation of preclinical findings into clinical applications has been slow, limiting improvements in patients...
DNA-methylation eraser TET2 activates WTIP expression to suppress an AKT-dependent chemoresistance of gastric cancer [0.03%]
TET2通过激活WTIP表达抑制胃癌的AKT依赖性的化疗抗性
Yan Guo,Hongyang Yu,Jinyang Li et al.
Yan Guo et al.
Chemoresistance is one of the major causes of the failure in gastric cancer (GC) treatment and leads to poor clinical outcomes. Ten-eleven translocation (TET) 2 expression and activity are frequently reduced in solid tumors. However, whethe...
Corrigendum to "PRMT1 methylates METTL14 to modulate its oncogenic function" [Neoplasia 42 (2023) 100912] [0.03%]
“PRMT1甲基化METTL14以调节其致癌功能”一文的勘误(2023年42卷100912页)[1]
Jingchao Wang,Zhen Wang,Hiroyuki Izunuka et al.
Jingchao Wang et al.
Published Erratum
Neoplasia (New York, N.Y.). 2025 Apr 23:65:101167. DOI:10.1016/j.neo.2025.101167 2025
An antibody targeting an immune checkpoint molecule BTN2A2 enhances anti-tumor immunity [0.03%]
靶向免疫检查点分子BTN2A2的抗体可增强抗肿瘤免疫反应
Li Xiao,Rong Hu,Wei Chen et al.
Li Xiao et al.
Tumors exploit immune checkpoints to evade immune responses. Therefore, targeting these checkpoints has become a key strategy in cancer immunotherapy. In this study, we have developed a novel immune checkpoint inhibitor (ICI) targeting the ...
Activation of PERK/eIF2α/ATF4 signaling inhibits ERα expression in breast cancer [0.03%]
活化PERK/eIF2α/ATF4信号抑制乳腺癌中雌激素受体α的表达
Yuanli Wu,Gang Wang,Ruixue Yang et al.
Yuanli Wu et al.
Approximately 70-80% of breast cancers rely on estrogen receptor alpha (ERα) for growth. The unfolded protein response (UPR), a cellular response to endoplasmic reticulum stress (ERS), is an important process crucial for oncogenic transfor...
Establishing a comprehensive panel of patient-derived xenograft models for high-grade endometrial carcinoma: molecular subtypes, genetic alterations, and therapeutic target profiling [0.03%]
建立高分级子宫内膜癌患者来源异种移植模型的全面谱系：分子亚型、遗传改变及治疗靶标分析
Sho Sato,Shigehiro Yagishita,Hiroshi Yoshida et al.
Sho Sato et al.
Background: High-grade endometrial cancer (EC) has a poor prognosis, but molecular classification-based treatments present new therapeutic opportunities. Antibody-drug conjugates (ADC) emerge as promising tools, yet a dee...
Systemic inflammation in response to radiation drives the genesis of an immunosuppressed tumor microenvironment [0.03%]
辐射诱发的全身性炎症促进免疫抑制型肿瘤微环境的形成
Lin Ma,Jian-Hua Mao,Mary Helen Barcellos-Hoff
Lin Ma
The composition of the tumor immune microenvironment has become a major determinant of response to therapy, particularly immunotherapy. Clinically, a tumor microenvironment lacking lymphocytes, so-called "cold" tumors, are considered poor c...
L-methionine promotes CD8+ T cells killing hepatocellular carcinoma by inhibiting NR1I2/PCSK9 signaling [0.03%]
L-甲硫氨酸通过抑制NR1I2 / PCSK9信号促进CD8 + T细胞杀伤肝癌
Chengsha Yuan,Changpeng Hu,Huyue Zhou et al.
Chengsha Yuan et al.
Background: Liver cancer has consistently high incidence and mortality rates among malignant tumors. PCSK9, a target for hypercholesterolemia therapy, has recently been identified as an inhibitor of anti-tumor immunity, a...