PRMT1 inhibitor MS023 suppresses RNA splicing to sensitize small cell lung cancer to DNA damaging agents [0.03%]
赖氨酸甲基转移酶PRMT1抑制剂MS023通过干扰RNA剪接增强小细胞肺癌DNA损伤修复抑制剂的疗效
Mansi K Aparnathi,Sami Ul Haq,Jonathan St-Germain et al.
Mansi K Aparnathi et al.
Small cell lung cancer (SCLC) is a highly aggressive form of cancer, commonly treated with DNA-damaging therapies such as chemotherapy and radiotherapy. Unfortunately, relapse occurs early and frequently, suggesting that epigenetic mechanis...
Escitalopram facilitates tumor growth and metastasis in rodents: Is it safe? [0.03%]
艾司西酞普兰可促进小鼠和大鼠的肿瘤生长及转移：安全吗？
Yosi Azan,Adam Margalit,Gal Wiener et al.
Yosi Azan et al.
Cancer patients are often treated perioperatively with serotonin reuptake inhibitors (SSRIs) to counteract anxiety and depression. Recent studies suggest that long-term cancer outcomes may also be affected by SSRI use in an agent-dependent ...
Twist1-induced suppression of oncogene-induced senescence in non-small cell lung cancer requires the transactivation domain of Twist1 [0.03%]
TWIST1通过其转录激活域诱导非小细胞肺癌中抑癌基因的衰老抑制作用
Audrey Lafargue,Hailun Wang,Sivarajan T Chettiar et al.
Audrey Lafargue et al.
Non-small cell lung carcinoma (NSCLC) is a major cause of cancer mortality. High expression of the epithelial-to-mesenchymal transition transcription factor (EMT-TF) Twist1 is strongly associated with metastatic cancers and with treatment r...
Immunohistochemical and molecular evolutionary features of jejunoileal adenocarcinoma unveiled through comparative analysis with colorectal adenocarcinoma [0.03%]
通过与结肠直肠腺癌的比较分析揭示空回肠腺癌的免疫组化和分子进化特征
Rei Ishikawa,Hidetaka Yamada,Hirotomo Saitsu et al.
Rei Ishikawa et al.
Jejunoileal adenocarcinoma (JIAC) is a rare type of malignancy, the clinicopathological, genetic, and evolutionary characteristics of which have rarely been reported. In this study, 52 patients with JIAC and 182 patients with colorectal ade...
Exploring the full potential of Pyrotinib in HER2-positive metastatic breast cancer [0.03%]
探索吡咯替尼在HER2阳性转移性乳腺癌中的全部潜力
Wei-Zhen Tang,Kang-Jin Huang,Tai-Hang Liu
Wei-Zhen Tang
Saturated fat exacerbates mitochondrial dysfunction through remodelling of ATP production and inflammation in Barrett's oesophagus compared to monounsaturated fat, particularly in contrast to oesophageal adenocarcinoma [0.03%]
与单不饱和脂肪相比，饱和脂肪通过重塑ATP产生和炎症加重巴雷特食管的线粒体功能障碍，尤其是与食管腺癌相比时更是如此
Kathleen A J Mitchelson,Fiona O&#x;Connell,Kieran Wynne et al.
Kathleen A J Mitchelson et al.
Obesity-related oesophageal adenocarcinoma (OAC), arising from Barrett's oesophagus (BO), incidence rates are rising coincident with high-fat diets. However, adipose tissue phenotype drives metabolic characteristics. Prior feeding studies d...
Differential prognostic association of systemic inflammatory biomarkers on survival outcomes in head and neck squamous cell carcinoma patients by human papillomavirus status [0.03%]
人乳头瘤病毒感染状态对头颈鳞癌患者系统性炎症生物标志物预后价值的影响
Pardis Noormohammadpour,Katrina Hueniken,Martha Pienkowski et al.
Pardis Noormohammadpour et al.
Systemic inflammatory response (SIR) markers are prognostic in various cancers. In a prospective cohort study (2006-2019) involving 2044 head and neck squamous cell carcinomas (HNSCC) patients, we assessed the prognostic associations of SIR...
MYC alterations in multiple myeloma: Genetic insights and prognostic impact [0.03%]
多发性骨髓瘤中MYC改变的遗传学见解和预后价值
Sara Cristóbal-Vargas,Myriam Cuadrado,Norma C Gutiérrez
Sara Cristóbal-Vargas
Multiple myeloma (MM) is a hematologic malignancy with high genetic complexity. The genetic alterations that drive MM have classically been classified as primary abnormalities, including IGH translocations and hyperdiploidy, and secondary a...
SCFβ-TrCP targets Ajuba for degradation in a GSK3β-dependent manner in colorectal cancer [0.03%]
SCFβ-TrCP依赖GSK3β以泛素化降解Ajuba在结直肠癌中的作用
Liangshan Li,Feng Zhu,Yupei Liang et al.
Liangshan Li et al.
Ajuba (ajuba LIM protein, JUB) is a member of the Ajuba family, and its oncogenic biological functions in colorectal cancer (CRC) have been extensively reported including proliferation, metastasis and resistance to chemotherapy. Although co...
Response of GEM models of neuroblastoma to cabozantinib assessed by multiparametric magnetic resonance imaging [0.03%]
基于多参数磁共振成像的神经母细胞瘤GEM模型对卡博替尼的反应评估
Gilberto S Almeida,Philippa King,Albert Hallsworth et al.
Gilberto S Almeida et al.
Background: In neuroblastoma MYCN amplification is associated with enhanced angiogenesis and poor survival. Mutations in the anaplastic lymphoma kinase (ALK) gene can occur with MYCN amplification, conferring a very poor ...