Targeting monopolar spindle kinase I (Mps1 or TTK) induces radiosensitization in syngeneic models of triple negative breast cancer (TNBC) and potentiates type I interferon (T1IFN) signaling [0.03%]
靶向单极纺锤体激酶I（Mps1或TTK）可使同基因三阴性乳腺癌（TNBC）模型放射增敏并增强I型干扰素（T1IFN）信号转导
Kassidy M Jungles,Caroline R Bishop,Cydnee M Wilson et al.
Kassidy M Jungles et al.
Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype that disproportionately impacts Black women and has limited effective therapeutic options. Consequently, there is an urgent need to develop novel approaches for the...
Single-cell proteomic analysis reveals Multiple Myeloma heterogeneity and the dynamics of the tumor immune microenvironment in precursor and advanced states [0.03%]
单细胞蛋白质组分析揭示了前体和晚期状态浆细胞瘤的异质性和肿瘤免疫微环境动力学
Mohamed Kamal,Stephanie N Shishido,Jeremy Mason et al.
Mohamed Kamal et al.
Multiple myeloma (MM) is an aggressive hematologic malignancy arising from plasma cell (PC) proliferation in the bone marrow, progressing from its precursor states MGUS and SMM. Despite therapeutic advances, MM remains incurable, underscori...
EGFRvIII-driven microenvironmental fibroblast activation and transformation accelerate oral cancer progression via lipocalin-2/STAT3 axis [0.03%]
EGFRvIII驱动的微环境成纤维细胞活化和转化通过LCN2 / STAT3轴加速口腔癌进展
Hsuan-Yu Peng,Kwang-Yu Chang,Wei-Min Chang et al.
Hsuan-Yu Peng et al.
Oral squamous cell carcinoma (OSCC) is an aggressive malignancy frequently characterized by dysregulated epidermal growth factor receptor (EGFR) signaling. Among EGFR mutation, EGFRvIII, an extracellular domain truncated form without exons ...
Deletion of the transcription factor ATF4 in a model of clear cell renal cell carcinoma [0.03%]
在透明细胞肾细胞癌模型中删除转录因子ATF4
Yuling Chi,Shireen Chikara,Eduardo Mere Del Aguila et al.
Yuling Chi et al.
Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer in adults. We generated TRAnsgenic of Cancer of the Kidney (TRACK) mice that express a triple-mutant (P402A, P564A, and N803A) human HIF1α construct specifica...
The deubiquitinase USP7 stabilizes HER2 expression and promotes breast cancer progression [0.03%]
去泛素化酶USP7稳定HER2表达并促进乳腺癌进展
Xiaoyue He,Xiaohong Xia,Ziying Lei et al.
Xiaoyue He et al.
The overexpression and amplification of HER2 occurs in breast cancer. However, the mechanism of HER2 action in tumor has not yet been elucidated. HER2 can be degraded by the UPS system, and several HER2-associated E3s have been identified, ...
Corrigendum to "Ovulation sources ROS to confer mutagenic activities on the TP53 gene in the fallopian tube epithelium" [Neoplasia 59 (2025 Dec 4) 101085] [0.03%]
“排卵产生ROS，使输卵管上皮中的TP53基因发生致突变作用”一文的勘误(2025年12月4日号)
Kanchana Subramani,Hsuan-Shun Huang,Pao-Chu Chen et al.
Kanchana Subramani et al.
Published Erratum
Neoplasia (New York, N.Y.). 2025 May 29:66:101183. DOI:10.1016/j.neo.2025.101183 2025
Alteration in expression and subcellular localization of the androgen receptor- regulated FAM111A protease is associated with emergence of castration resistant prostate cancer [0.03%]
雄激素受体调节的FAM111A蛋白酶的表达和亚细胞定位的变化与去势抵抗性前列腺癌的发生有关
Maria Malvina Tsamouri,Stephen J Libertini,Salma Siddiqui et al.
Maria Malvina Tsamouri et al.
The androgen receptor (AR) is a pivotal regulator of growth and survival of prostate cancer (PCa) and the majority of lethal castration-resistant prostate cancers (CRPC) remain reliant on AR signaling. PCa exhibits variability in progressio...
CD56 on intratumoral NK cells: orchestrating NK cell-mediated anti-tumor effects in bladder cancer [0.03%]
膀胱癌肿瘤内驻留NK细胞上的CD56：协调NK细胞抗肿瘤效应
Zaineb Hassouneh,Onika D V Noel,Niannian Ji et al.
Zaineb Hassouneh et al.
Bladder cancer (BCa) exhibits favorable responses to immunotherapy, but a significant percentage of patients fail to show a response owing to an inadequate tumor-immune landscape. We previously showed that NK cells are one of the predominan...
CYP1B1 promotes angiogenesis and sunitinib resistance in clear cell renal cell carcinoma via USP5-mediated HIF2α deubiquitination [0.03%]
CYP1B1通过USP5介导的HIF2α去泛素化促进透明细胞肾细胞癌血管生成和舒尼替尼耐药性
Ke Ma,Qinyu Li,Yi Zhang et al.
Ke Ma et al.
Clear cell renal cell carcinoma (ccRCC) is strongly aetiologically associated with von Hippel‒Lindau (VHL) tumour suppressor gene mutations, which result in constitutive activation of hypoxia-inducible factors and pathological angiogenesis...
[18F]-FLT-PET to evaluate how the sequencing of chemotherapies impacts the efficacy of combination treatment in mouse models of triple-negative breast cancer [0.03%]
FLT-PET检测三阴性乳腺癌小鼠模型中不同化疗药物顺序对联合治疗疗效的影响
Yun Lu,Jonathan Moye,Adriana V F Massicano et al.
Yun Lu et al.
Introduction: Triple-negative breast cancer (TNBC) lacks targeted therapies due to an absence of biomarkers, making chemotherapy the primary treatment option for early-stage cancer. This study evaluates whether the order ...