DHX34 deficiency triggers tumor-intrinsic immunity via a dsRNA-mediated type I interferon pathway activation in HCC [0.03%]
DHX34缺陷通过双链RNA介导的I型干扰素信号通路激活触发肝癌细胞固有免疫反应
Chunli Zhang,Limin Huang,Zeyu Li et al.
Chunli Zhang et al.
Tumors often evade immune surveillance by crippling their immunogenicity in the microenvironment. DHX34, an RNA helicase involved in nonsense-mediated mRNA decay pathway, is critical for aberrant RNA degradation. However, the effect of DHX3...
miRTARGET: An integrated web tool for the identification of microRNA targets with potential therapeutic or prognostic value in cancer [0.03%]
miRTARGET：一个用于在癌症中鉴定具有潜在治疗价值或预后价值的microRNA靶点的集成型网络工具
Matjaz Rokavec,Heiko Hermeking
Matjaz Rokavec
miRTARGET (https://www.mirtarget.com) is a web tool for the identification of miRNA targets. It integrates experimental miRNA-related datasets and computational algorithms to generate prediction scores for targets of 1744 human miRNAs. The ...
Screening and identification of HLA-A2-restricted neoepitopes for immunotherapy in endocrine therapy-resistant breast cancer [0.03%]
耐内分泌治疗乳腺癌的HLA-A2限制性新表位筛选及鉴定
Mingshuang Wang,Liwei Pang,Yingjie Sun et al.
Mingshuang Wang et al.
Endocrine therapy has shown significant clinical efficacy in estrogen receptor alpha (ERα)-positive breast cancer management, but the emergence of therapy-resistant mutations significantly undermines treatment outcomes, frequently leading ...
Regulatory mechanisms of the Hippo/YAP axis by G-protein coupled estrogen receptor in gastric signet-ring cell carcinoma [0.03%]
G蛋白偶联雌激素受体调控胃印戒细胞癌Hippo/YAP信号轴的机制研究
Yufei Wang,Yuanlin Sun,Weizhu Zhao et al.
Yufei Wang et al.
Although aberrant activation of the Hippo/YAP axis has been implicated in the development of gastric cancer, functional studies of this cascade in the context of gastric signet-ring cell carcinoma (GSRC) remain absent. Our previous single-c...
Prognostic role of high MTAP expression is reversed by the ERG status in prostate cancer treated by radical prostatectomy [0.03%]
高MTAP表达的预后作用在根治性前列腺切除术治疗的前列腺癌中被ERG状态逆转
Natalia Gorbokon,Seyma Büyücek,Henning Plage et al.
Natalia Gorbokon et al.
Loss of S-methyl-5'-thioadenosine phosphorylase (MTAP) expression offers a therapeutic option through synthetic lethality and confers resistance to immune checkpoint inhibitors in various cancers. To assess MTAP prevalence in prostate cance...
Rezatapopt: A promising small-molecule "refolder" specific for TP53Y220C mutant tumors [0.03%]
Rezatapopt：一种有前途的小分子“复性剂”，专门针对TP53Y220C突变肿瘤
Kostas A Papavassiliou,Alice G Vassiliou,Athanasios G Papavassiliou
Kostas A Papavassiliou
Inactivation of p53 due to mutation is observed in approximately half of all human cancer cases, therefore, restoration of the tumor suppressor function of oncogenic p53 mutants represents an attractive and rational therapeutic approach. Cu...
Cancer-associated VEGFR2R1032Q sustains receptor activation also by promoting ligand-independent hetero-dimerization with co-expressed wild-type VEGFR2 and translocation into lipid rafts [0.03%]
与癌症相关的VEGFR2R1032Q通过促进与共表达的野生型VEGFR2异二聚化并转位到脂筏来维持受体激活 такжеFilterWhere
Cosetta Ravelli,Michela Corsini,Roberto Bresciani et al.
Cosetta Ravelli et al.
The substitution R1032Q is the most frequent non-synonymous mutation of the vascular endothelial growth factor receptor 2 (VEGFR2) in cancer patients, classified as a loss-of-function variant. Here we characterize the molecular bases of its...
Comparative effects of combustible cigarette versus electronic cigarette exposures on KRAS mutant lung cancer promotion [0.03%]
可燃香烟与电子烟对KRAS基因突变型肺癌的致癌促进作用的比较研究
Walter V Velasco,Maria T Grimaldo,Nastaran Karimi et al.
Walter V Velasco et al.
Despite the emerging public health concern related to the use of electronic cigarette vapors (ECV), its impact on lung cancer is poorly understood. We assessed the effect of ECV on lung tumorigenesis in a mouse model of lung adenocarcinoma....
ACSL4 knockdown inhibits colorectal cancer progression through stimulating anti-tumor immunity [0.03%]
ACSL4敲低通过刺激抗肿瘤免疫抑制结直肠癌进展
Yiming Liu,Xingyu Jiang,Dongquan Jing et al.
Yiming Liu et al.
Background: Long-chain acyl-CoA synthetase 4 (ACSL4), a crucial modulator of ferroptosis, is associated with tumor progression, though its impact on colorectal cancer (CRC) immune dynamics is not fully understood. ...
Corrigendum to "DNA-methylation eraser TET2 activates WTIP expression to suppress an AKT-dependent chemoresistance of gastric cancer" [Neoplasia volume 2025 Apr 24:65:101166] [0.03%]
“DNA甲基化消除剂TET2通过激活WTIP表达抑制胃癌AKT依赖性化疗耐药”一文中“volume 2025 Apr 24:65:101166”的更正
Yan Guo,Hongyang Yu,Jinyang Li et al.
Yan Guo et al.
Published Erratum
Neoplasia (New York, N.Y.). 2025 Jun 10:66:101191. DOI:10.1016/j.neo.2025.101191 2025