USP20 mediates malignant phenotypic changes in bladder cancer through direct interactions with YAP1 [0.03%]
USP20通过与YAP1的直接相互作用介导膀胱癌的恶性表型变化
Wensun Chen,Siqi Wu,Yifan Chen et al.
Wensun Chen et al.
Yes-associated protein 1 (YAP1) has attracted attention for its potential in the treatment of various types of malignancies. The Hippo-YAP1 axis is inhibited in bladder cancer (BC), which is a major driver of BC progression and oncogenesis....
circUBR5 promotes ribosome biogenesis and induces docetaxel resistance in triple-negative breast cancer cell lines via the miR-340-5p/CMTM6/c-MYC axis [0.03%]
circUBR5通过miR-340-5p/CMTM6/c-MYC轴促进核糖体生物发生并诱导三阴性乳腺癌细胞系对多西他赛的耐药性
Xuedong Wang,Xinping Wang,Juan Gu et al.
Xuedong Wang et al.
Objective: Docetaxel (DTX) represents an effective chemotherapeutic agent for treating triple-negative breast cancer (TNBC), but the efficacy is strongly limited by drug resistance. c-MYC-mediated ribosome biogenesis is c...
Identification of TUBB3 as an immunotherapy target in lung cancer by genome wide in vivo CRISPR screening [0.03%]
基因组范围内的体内CRISPR筛选鉴定TUBB3为肺癌免疫治疗靶点
Dan Zhao,Ravindra Deshpande,Kerui Wu et al.
Dan Zhao et al.
Recent development of immune checkpoint inhibitors has revolutionized cancer immunotherapy. Although these drugs show dramatic effects on a subset of cancer patients, many other tumors are non-responsive and the pathological mechanism of th...
Sonia A M Ferkel,Elizabeth A Holman,Raoul S Sojwal et al.
Sonia A M Ferkel et al.
Colorectal cancer encompasses a heterogeneous group of malignancies that differ in pathophysiological mechanisms, immune response and infiltration, therapeutic response, and clinical prognosis. Numerous studies have highlighted the clinical...
Phoebe Power,Joelle P Straehla,Jason Fangusaro et al.
Phoebe Power et al.
The last quarter century has heralded dramatic changes in the field of pediatric neuro-oncology, with the era defined by profound developments in the understanding of the biological underpinnings of childhood central nervous system (CNS) tu...
Ovulation sources ROS to confer mutagenic activities on the TP53 gene in the fallopian tube epithelium [0.03%]
排卵产生ROS从而赋予输卵管上皮细胞中TP53基因致突变的能力
Kanchana Subramani,Hsuan-Shun Huang,Pao-Chu Chen et al.
Kanchana Subramani et al.
Introduction: Epidemiological studies have implicated ovulation as a risk factor for ovarian high-grade serous carcinoma (HGSC) at the initiation stage. Precancerous lesions of HGSC commonly exhibit TP53 mutations attribu...
Daniel Peña-Oyarzún,Andrew F G Quest,Lorena Lobos-González et al.
Daniel Peña-Oyarzún et al.
Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer, which is usually preceded by a potentially malignant disorder histologically diagnosed as dysplasia. We and others have provided evidence for the pro-carcinogenic r...
Suppression of ADP-ribosylation reversal triggers cell vulnerability to alkylating agents [0.03%]
ADP核糖转移反应的抑制使细胞易受烷基化剂的影响
Rocco Caggiano,Evgeniia Prokhorova,Lena Duma et al.
Rocco Caggiano et al.
The ADP-ribosyl hydrolases PARG and ARH3 counteract PARP enzymatic activity by removing ADP-ribosylation. PARG and ARH3 activities have a synthetic lethal effect; however, the specific molecular mechanisms underlying this response remain un...
XAF1 is secreted from stressed tumor cells to activate T cell-mediated tumor surveillance via Lck-ERK signaling [0.03%]
XAF1通过Lck-ERK信号激活T细胞介导的肿瘤监视并从应激肿瘤细胞中分泌出来
Jieun Ahn,Seung-Hun Jang,Sungchan Jang et al.
Jieun Ahn et al.
X-linked inhibitor of apoptosis-associated factor 1 (XAF1) is a stress-inducible tumor suppressor that is commonly inactivated in multiple types of human malignancies. Nevertheless, the molecular basis for the XAF1-mediated tumor suppressio...
5-Aza-2'-deoxycytidin (Decitabine) increases cancer-testis antigen expression in head and neck squamous cell carcinoma and modifies immune checkpoint expression, especially in CD39-positive CD8 and CD4 T cells [0.03%]
5-aza-2'-脱氧胞苷（地西他滨）可上调头颈部鳞癌中的癌症睾丸抗原表达并改变免疫检查点在CD39阳性CD8和CD4 T细胞的表达
Adrian Fehn,Adrian von Witzleben,Ayla Grages et al.
Adrian Fehn et al.
Failure of immunotherapy in head and neck squamous cell carcinoma (HNSCC) patients represents an unmet need to augment leverage of adaptive immunity. Immunogenic cancer-testis antigen (CTA) expression as well as lymphocyte differentiation a...