Systemic brain dissemination of glioblastoma requires transdifferentiation into endothelial-like cells via TGF-β-ALK1-Smad1/5 signaling [0.03%]
胶质母细胞瘤的系统性脑转移需要通过TGF-β-ALK1-Smad1 / 5信号传导转变为内皮样细胞
Thomas M B Ware,Adilson Fonseca Teixeira,Josephine Iaria et al.
Thomas M B Ware et al.
Glioblastoma is the most aggressive type of brain cancer, but treatment improvements for glioblastoma patients remain stagnated for over 20 years. This is despite the large number of clinical trials that have attempted to replicate the succ...
Kinomic profiling to predict sunitinib response of patients with metastasized clear cell Renal Cell Carcinoma [0.03%]
用于预测转移性透明细胞肾细胞癌患者对舒尼替尼反应的激酶表达和活性谱分析
Jeannette C Oosterwijk-Wakka,Liesbeth Houkes,Loes F M van der Zanden et al.
Jeannette C Oosterwijk-Wakka et al.
Introduction: Treatment with Sunitinib, a potent multitargeted receptor tyrosine kinase inhibitor (TKI) has increased the progression-free survival (PFS) and overall-survival (OS) of patients with metastasized renal cell ...
Incidence, mortality, and global burden of retinoblastoma in 204 countries worldwide from 1990 to 2021: Data and systematic analysis from the Global Burden of Disease Study 2021 [0.03%]
204个国家和地区1990年至2021年视网膜母细胞瘤的发病、死亡及疾病负担：全球疾病负担研究（GBD 2021）数据分析与系统分析结果
Linyan Wang,Jianing Chen,Yunhan Shen et al.
Linyan Wang et al.
Background: Retinoblastoma (Rb), the primary intraocular malignancy in children, poses significant risks, yet its overall burden remains inadequately assessed. This study aims to analyze global Rb trends using Global Burd...
Recent advances of photodiagnosis and treatment for head and neck squamous cell carcinoma [0.03%]
头颈部鳞癌的光诊疗新进展
Yining Zhang,Zhenfang Li,Chengchi Zhang et al.
Yining Zhang et al.
Head and neck squamous cell carcinoma (HNSCC) are the most common type of head and neck tumor that severely threatens human health due to its highly aggressive nature and susceptibility to distant metastasis. The diagnosis of HNSCC currentl...
Clinical utility and predictive value of cerebrospinal fluid cell-free DNA profiling in non-small cell lung cancer patients with leptomeningeal metastasis [0.03%]
非小细胞肺癌脑膜转移患者脑脊液游离DNA检测的临床应用价值及预测价值研究
Sheng-Kai Liang,Wei-Yu Liao,Jin-Yuan Shih et al.
Sheng-Kai Liang et al.
Leptomeningeal metastasis (LM) is a challenging complication of non-small cell lung cancer (NSCLC). Cerebrospinal fluid (CSF) cell-free DNA (cfDNA) analysis using next-generation sequencing (NGS) offers insights into resistance mechanisms a...
Alessandro Ottaiano,Mariachiara Santorsola,Roberto Sirica et al.
Alessandro Ottaiano et al.
Background: Oligo-metastatic disease (OMD) in colon cancer patients exhibits distinct clinical behavior compared to poly-metastatic disease (PMD), with a more responsive and indolent course. This study aims to identify cl...
Tumor-associated macrophages promote bladder cancer metastasis through the CCL20-CCR6 axis [0.03%]
肿瘤相关巨噬细胞通过CCL20-CCR6轴促进膀胱癌转移
Ryunosuke Nakagawa,Kouji Izumi,Kaoru Hiratsuka et al.
Ryunosuke Nakagawa et al.
We investigated the mechanisms of interaction between bladder cancer (BC) cells and tumor-associated macrophages (TAMs). Coculturing BC cell lines (UMUC3 and T24) with macrophage-like cells differentiated from THP-1 into M2-like TAMs reveal...
Transcriptomic and proteomic profiling identifies feline fibrosarcoma as clinically amenable model for aggressive sarcoma subtypes [0.03%]
转录组和蛋白质基因组分析鉴定出猫纤维肉瘤可作为侵袭性肉瘤亚型的临床适用模型
Mikiyo Weber,Daniel Fuchs,Amiskwia Pöschel et al.
Mikiyo Weber et al.
Fibrosarcomas (FSA) are malignant mesenchymal tumors characterized by low chemo- and radiosensitivity. Development of novel treatment strategies for human adult FSA is hindered by the low incidence and the absence of suitable clinical model...
USP14 inhibition by degrasyn induces YAP1 degradation and suppresses the progression of radioresistant esophageal cancer [0.03%]
USP14抑制剂degrasyn诱导YAP1降解并抑制放射抵抗性食管癌进展
Fang Yuan,Juan Xu,Lingmei Xuan et al.
Fang Yuan et al.
Background: Radiotherapy is a major modality for esophageal cancer (ESCA) treatment, yet radioresistance severely hampers its therapeutic efficacy. Ubiquitin-specific peptidase 14 (USP14) is a novel deubiquitinase and can...
Optimal radiation dose to induce an abscopal effect by combining carbon-ion radiotherapy and anti-CTLA4 antibody [0.03%]
调强碳离子放疗联合抗CTLA-4抗体诱导远隔效应的放射剂量学研究
Liqiu Ma,Yang Li,Yoshimitsu Sakamoto et al.
Liqiu Ma et al.
Background and purpose: Although carbon-ion radiotherapy (CIRT) has led to good outcomes, controlling metastasis is still crucial for improving overall survival. This study aimed to evaluate the effectiveness of by two co...