Breast Cancer Heterogeneity Examined by High-Sensitivity Quantification of PIK3CA, KRAS, HRAS, and BRAF Mutations in Normal Breast and Ductal Carcinomas [0.03%]
高灵敏度量化PIK3CA、KRAS、HRAS和BRAF突变检测正常乳腺和导管癌的乳腺癌异质性
Meagan B Myers,Malathi Banda,Karen L McKim et al.
Meagan B Myers et al.
Mutant cancer subpopulations have the potential to derail durable patient responses to molecularly targeted cancer therapeutics, yet the prevalence and size of such subpopulations are largely unexplored. We employed the sensitive and quanti...
ATP-Dependent Lon Protease Contributes to Helicobacter pylori-Induced Gastric Carcinogenesis [0.03%]
ATP依赖型Lon蛋白酶促进幽门螺杆菌诱导的胃癌发生发展
Bin Luo,Minggang Wang,Nengyi Hou et al.
Bin Luo et al.
Helicobacter pylori infection is the strongest risk factor for development of gastric cancer. Host cellular stress responses, including inflammatory and immune responses, have been reported highly linked to H. pylori-induced carcinogenesis....
A Truncated form of CD200 (CD200S) Expressed on Glioma Cells Prolonged Survival in a Rat Glioma Model by Induction of a Dendritic Cell-Like Phenotype in Tumor-Associated Macrophages [0.03%]
一种截短的CD200（CD200S）延长了异种移植原发性大鼠脑瘤的生存期，其机制或为通过将肿瘤相关巨噬细胞诱导成树突状样表型来增强抗肿瘤免疫反应
Kana Kobayashi,Hajime Yano,Akihiro Umakoshi et al.
Kana Kobayashi et al.
CD200 induces immunosuppression in myeloid cells expressing its receptor CD200R, which may have consequences for tumor immunity. We found that human carcinoma tissues express not only full-length CD200 (CD200L) but also its truncated form, ...
Complex Chromosomal Rearrangements in B-Cell Lymphoma: Evidence of Chromoanagenesis? A Case Report [0.03%]
B细胞淋巴瘤中的复杂染色体重排：染色体生成的证据？一例报告
Veronica Ortega,Alka Chaubey,Christina Mendiola et al.
Veronica Ortega et al.
Genomic instability is a well-known hallmark of cancer. Recent genome sequencing studies have led to the identification of novel phenomena called chromothripsis and chromoanasynthesis in which complex genomic rearrangements are thought to b...
MDM2 Inhibition Sensitizes Prostate Cancer Cells to Androgen Ablation and Radiotherapy in a p53-Dependent Manner [0.03%]
MDM2抑制通过p53依赖的方式使前列腺癌细胞对雄激素消融和放疗产生敏感性
Felix Y Feng,Yu Zhang,Vishal Kothari et al.
Felix Y Feng et al.
Purpose: Increased murine double minute 2 (MDM2) expression, independent of p53 status, is associated with increased cancer-specific mortality for men with prostate cancer treated with radiotherapy. We assessed MI-219, a ...
A Potent Derivative of Indolizino[6,7-b]Indole for Treatment of Human Non-Small Cell Lung Cancer Cells [0.03%]
一种吲哚并[6,7-b]吲哚衍生物用于治疗人类非小细胞肺癌细胞
Chi-Wei Chen,Ming-Hsi Wu,Yi-Fan Chen et al.
Chi-Wei Chen et al.
The therapeutic effect in non-small cell lung cancer (NSCLC) patients is limited because of intrinsic and acquired resistance. Thus, an unmet need exists for the development of new drugs to improve the therapeutic efficacy in NSCLC patients...
Regulation of Glioblastoma Tumor-Propagating Cells by the Integrin Partner Tetraspanin CD151 [0.03%]
整合素配体四跨膜蛋白CD151调节胶质母细胞瘤肿瘤干细胞属性
Jessica Tilghman,Paula Schiapparelli,Bachuchu Lal et al.
Jessica Tilghman et al.
Glioblastoma (GBM) stem cells (GSCs) represent tumor-propagating cells with stem-like characteristics (stemness) that contribute disproportionately to GBM drug resistance and tumor recurrence. Understanding the mechanisms supporting GSC ste...
Prox1-Heterozygosis Sensitizes the Pancreas to Oncogenic Kras-Induced Neoplastic Transformation [0.03%]
Prox1杂合子状态使胰腺易发生Kras诱导的肿瘤形成
Yiannis Drosos,Geoffrey Neale,Jianming Ye et al.
Yiannis Drosos et al.
The current paradigm of pancreatic neoplastic transformation proposes an initial step whereby acinar cells convert into acinar-to-ductal metaplasias, followed by progression of these lesions into neoplasias under sustained oncogenic activit...
Elucidation of Resistance Mechanisms to Second-Generation ALK Inhibitors Alectinib and Ceritinib in Non-Small Cell Lung Cancer Cells [0.03%]
非小细胞肺癌细胞系对二代ALK抑制剂艾乐昔替尼和塞瑞替尼的耐药机制分析
Xuyuan Dong,Ester Fernandez-Salas,Enxiao Li et al.
Xuyuan Dong et al.
Crizotinib is the first anaplastic lymphoma kinase (ALK) inhibitor to have been approved for the treatment of non-small cell lung cancer (NSCLC) harboring an ALK fusion gene, but it has been found that, in the clinic, patients develop resis...
Rat Prostate Tumor Cells Progress in the Bone Microenvironment to a Highly Aggressive Phenotype [0.03%]
小鼠前列腺肿瘤细胞在骨微环境中向高度侵袭性表型进展
Sofia Halin Bergström,Stina H Rudolfsson,Anders Bergh
Sofia Halin Bergström
Prostate cancer generally metastasizes to bone, and most patients have tumor cells in their bone marrow already at diagnosis. Tumor cells at the metastatic site may therefore progress in parallel with those in the primary tumor. Androgen de...