Genomic landscape and molecular evolutionary trajectories of renal epithelioid angiomyolipoma and benign angiomyolipoma [0.03%]
上皮样血管平滑肌脂肪瘤和良性血管平滑肌脂肪瘤的基因组景观及分子进化轨迹
Aihetaimujiang Anwaier,Yuanyuan Qu,Shiqi Ye et al.
Aihetaimujiang Anwaier et al.
Renal angiomyolipoma (AML) encompasses benign variants (lipomatous [L-AML], myomatous [M-AML]) and epithelioid AML (eAML), a potentially malignant subtype associated with aggressive behavior. While TSC1/TSC2 mutations are frequent, the mole...
Hepatocellular carcinoma escapes immune surveillance through deceiving thymus into recalling peripheral activated CD8+ T cells [0.03%]
肝细胞癌通过欺骗胸腺召回外周活化CD8+t细胞来逃避免疫监视
Qiaoting Hu,Xuefeng Wang,Yundan You et al.
Qiaoting Hu et al.
The role of thymic epithelial cells (TECs) in eliminating self-reactive T cells through the presentation of self-antigens is well-established. However, it remains unclear whether TECs can eliminate tumor-reactive CD8+ T cells by presenting ...
The TRIM22-CDT2 axis is the key mediator of the p53-Rb signals in growth control of HPV-positive cervical carcinoma cells [0.03%]
TRIM22-CDT2轴是HPV阳性宫颈癌细胞生长调控中p53-Rb信号的关键媒介
Qing Zhou,Hongfei Yu,Anliang Dong et al.
Qing Zhou et al.
Persistent infection with high-risk human papillomavirus (HPV) is the primary contributor to the development of cervical cancer. Although HPV oncoproteins E6 and E7 clearly trigger cervical tumorigenesis by inactivating p53 and Rb pathways,...
The DNA mismatch repair protein, MSH6 is a novel regulator of PD-L1 expression [0.03%]
DNA错配修复蛋白MSH6是PD-L1表达的新调节因子
Kirsten Brooksbank,Charlotte Smith,Eleni Maniati et al.
Kirsten Brooksbank et al.
Immune checkpoint inhibitors (ICIs) are extremely effective in a subgroup of mismatch repair-deficient (MMRd) cancers, but ∼50% remain resistant to treatment. We have shown for the first time that this may be due to the differential regula...
Biphasic behavior of T cell subsets reflects failure of early anti-myeloma response and leads to progressive T cell dysfunction [0.03%]
T细胞亚群的双相行为反映了早期抗浆细胞瘤反应失败并导致进行性T细胞功能障碍
Suchita Suryakant Jadhav,Vipin Sharma,Aharon Lion et al.
Suchita Suryakant Jadhav et al.
Introduction: Multiple Myeloma (MM) progresses over 2-3 decades through two pre-malignant stages (MGUS and SMM), culminating in clinically active disease. Given the limitations in acquiring sequential bone marrow (BM) sam...
Tumor neoantigens as key drivers of significant anti - tumor immunity in triple - negative breast cancer mouse models [0.03%]
肿瘤新抗原作为三阴性乳腺癌小鼠模型中显著抗肿瘤免疫的关键驱动因素
Yujeong Her,Jeong Yeon Kim,Hocheol Shin et al.
Yujeong Her et al.
Recent studies have highlighted the therapeutic potential of targeting tumor neoantigens in solid tumors; however, its efficacy in breast cancer remains unclear. Here, we evaluate the impact of tumor neoantigen-targeted strategies in a syng...
SMYD2 epigenetically activates BMP4/SMAD1/5/8/ID3 axis to enhance cancer stem cell properties and drive sorafenib resistance in hepatocellular carcinoma [0.03%]
SMYD2通过表观遗传激活BMP4/SMAD1/5/8/ID3轴以增强肝细胞癌的癌症干细胞特性并引起索拉非尼耐药性
Shanshan Wang,Weicheng Wu,Zhen Shi et al.
Shanshan Wang et al.
Background: Drug resistance prominently hampers the effects of sorafenib in hepatocellular carcinoma (HCC). Epigenetics play important roles in drug resistance. However, the contributions of SET And MYND Domain Containing...
SKI regulates rRNA transcription and pericentromeric heterochromatin to ensure centromere integrity and genome stability [0.03%]
SKI通过调节rRNA转录和异染色质来保证着丝粒的完整性和基因组稳定性
Víctor Pola-Véliz,David Carrero,Eduardo A Sagredo et al.
Víctor Pola-Véliz et al.
Accurate chromosome segregation and ribosomal gene expression silencing are essential for maintaining genome integrity, and disruptions in these processes are key for oncogenesis and cancer progression. Here, we demonstrate a novel role for...
New horizons in B-cell lymphoma immunotherapy: From immune checkpoints to precision medicine [0.03%]
B细胞淋巴瘤免疫治疗新进展：从免疫检查点到精准医学
RuiXin Zheng,YuXiao Li,KaiXin Shi et al.
RuiXin Zheng et al.
B-cell lymphoma, a malignancy in hematology with high heterogeneity, has its genesis and progression intricately associated with immune system regulation. Over the past three decades, transformative breakthroughs in B-cell malignancy invest...
The immune response against cancer is modulated by stromal cell fibronectin [0.03%]
基质细胞纤连蛋白可调节机体对癌的免疫反应
Alexander Lubosch,Lauren Pitt,Caren Zoeller et al.
Alexander Lubosch et al.
Cancer-associated fibroblasts remain poorly understood, with some of them originating from the bone marrow. We therefore took advantage of the diversity of bone marrow stromal cells to shed light on how fibroblasts modulate cancer growth. I...