Pyrazole-derived TRPC3 antagonist ameliorates synaptic dysfunctions and memory deficits in Alzheimer's disease models [0.03%]
Jiaxing Wang,Ling Chen,Zhengjun Wang et al.
Jiaxing Wang et al.
Transient receptor potential canonical (TRPC) channels are widely expressed in the brain; however, their precise roles in neurodegenerative diseases, such as Alzheimer's disease (AD), remain elusive. We found that TRPC3 expression is upregu...
Multi-omics and electrophysiological examination of GABAA receptors in the dorsolateral prefrontal cortex of humans with alcohol use disorder [0.03%]
J Granchi,B Salameh,B Miller et al.
J Granchi et al.
Alterations of GABAA receptors (GABAARs) following chronic alcohol are thought to be related to deficits in GABAergic signaling in individuals with alcohol use disorder (AUD). Whether those modifications affect the function of synaptic GABA...
Madeleine Curtis,David Balfour,Phillip Melton et al.
Madeleine Curtis et al.
Disordered eating is associated with a range of poor health outcomes that affect various body systems, including immune, metabolic, and stress-related processes. Biological ageing represents a potential mechanism through which disordered ea...
Analysis of rare coding variants in schizophrenia-associated genes and generalised cognition in the UK Biobank [0.03%]
Eilidh Fenner,Peter Holmans,Michael C O&#x;Donovan et al.
Eilidh Fenner et al.
Cognitive impairments in schizophrenia are associated with poor outcomes and are largely unimproved by current medications. It remains uncertain to what extent cognitive impairments arise from shared aetiology and biology with schizophrenia...
The Cognitive benefits of nitrate in patients with alcohol use disorder: unraveling the oral microbiome ectopic colonization pathway [0.03%]
Xiangxue Li,Kangqing Zhao,Jie Chen et al.
Xiangxue Li et al.
Our prior research revealed that dietary nitrate (NO₃⁻) may mitigate alcohol-induced cognitive impairment through oral microbiota modulation and attenuation of inflammatory responses in mice. While alcohol use disorder (AUD) is known to a...
Subjective and neurocognitive profiling of clinical doses of 3,4-methylenedioxymethamphetamine (MDMA) in healthy volunteers: implications for therapeutic use [0.03%]
Johannes G Ramaekers,Kim P C Kuypers,Franz X Vollenweider
Johannes G Ramaekers
MDMA's history spans military experimentation, recreational use, and clinical trials for PTSD treatment, reflecting both promise and controversy. While studies in heavy users suggested possible neurotoxicity, evidence remains inconclusive. ...
Daniel Dautan,Anderson Camargo,Per Svenningsson
Daniel Dautan
Convergent coexpression reveals shared biological mechanisms underlying common and rare variant risk in six neuropsychiatric disorders [0.03%]
Hanna Abe,Calwing Liao,Lide Han et al.
Hanna Abe et al.
Genome-wide association studies (GWAS) and large-scale rare variant burden analyses have identified both common and rare loss-of-function variants associated with neuropsychiatric and neurodegenerative disorders. Yet, the shared biological ...
Towards scalable biomarker discovery in posttraumatic stress disorder: triangulating genomic and phenotypic evidence from a health system biobank [0.03%]
Younga Heather Lee,Yingzhe Zhang,Ana Lucia Espinosa Dice et al.
Younga Heather Lee et al.
Biomarkers can potentially improve the diagnosis, monitoring, and treatment of posttraumatic stress disorder (PTSD). However, PTSD biomarkers that are scalable and easily integrated into real-world clinical settings have not been identified...
Laura M Fiori,Anjali Chawla,Vikram Nathan et al.
Laura M Fiori et al.
Suicide is one of the leading causes of death worldwide. Although suicidal behaviors demonstrate high heritability, identifying the underlying genetic factors has been challenging. Recent genome-wide association studies for suicidal behavio...