Convergent neuroimmune signaling underlying rapid antidepressant response to ketamine and psychedelics [0.03%]
氯胺酮和致幻剂快速抗抑郁反应的汇聚神经免疫信号机制
Gregory H Jones,Jessica R Gilbert,Jenessa N Johnston et al.
Gregory H Jones et al.
Despite distinct receptor targets, both ketamine and serotonergic psychedelics produce a rapid clinical response and share biological signatures that suggest convergence on common downstream molecular mediators. To identify shared biomarker...
Genetically informed dissection of multimodal brain aging and ten major psychiatric disorders [0.03%]
基于遗传学的多模态大脑衰老及十种主要精神疾病的研究分解
Qiyu Zhao,Qi An,Wenjie Cai et al.
Qiyu Zhao et al.
Brain age gap (BAG), defined as the deviation between neuroimaging-predicted brain age and chronological age, has emerged as an imaging-derived phenotype associated with psychiatric disorders. Although both BAG and psychiatric disorders are...
Correction: Optimized multichannel 4 mA vs conventional transcranial direct current stimulation for major depressive disorder: A randomized sham-controlled trial [0.03%]
校正：针对抑郁症的优化多通道4mA versus传统经颅直流电刺激：一项随机假刺激对照试验
Mohammad Ali Salehinejad,Marzieh Abdi,Mohsen Dadashi et al.
Mohammad Ali Salehinejad et al.
Published Erratum
Molecular psychiatry. 2026 Jul 27. DOI:10.1038/s41380-026-03780-4 2026
Machine learning reveals a multimodal, transdiagnostic signature of emotion dysregulation vulnerability across patients, offspring, and controls [0.03%]
机器学习揭示了患者、后代和对照组中情绪失调脆弱性的多模态、跨诊断特征
Luigi F Saccaro,Thomas Larrieu,Farnaz Delavari et al.
Luigi F Saccaro et al.
Emotion dysregulation (ED) is a core transdiagnostic feature of several psychiatric disorders, including borderline personality disorder, bipolar disorder, and attention-deficit/hyperactivity disorder. These ED disorders (EDD) exhibit overl...
Digital mood phenotyping predicts short- and long-term suicidal ideation across a two-year timescale [0.03%]
数字情绪表型预测两年时间跨度内的短期和长期自杀念头
Chang Lei,Xuan Geng,Zhijun Wu et al.
Chang Lei et al.
Suicide risk is disproportionately elevated among sexual and gender minority (SGM) individuals. Identifying time-varying risk states is critical for prevention, yet conventional assessments may not adequately capture mood fluctuations that ...
Association between parental ADHD and adverse offspring outcomes: Evidence from a nationwide Swedish register-based study [0.03%]
基于瑞典全国注册资料的父母注意力缺陷多动障碍与子代不良预后之间的关联性研究
Honghui Yao,Mengping Zhou,Isabell Brikell et al.
Honghui Yao et al.
The potential associations between parental ADHD and a broad spectrum of offspring health outcomes remain uncertain. We explored associations between parental ADHD and multiple adverse outcomes in offspring. We used linked Swedish national ...
Multi-omic data integration improves the resolution of the molecular etiology of autism in a mouse model [0.03%]
整合多组学数据可提高自闭症小鼠模型分子病因解析的分辨率
Carolina D Alberca,Kwangmoon Park,Ligia A Papale et al.
Carolina D Alberca et al.
Autism spectrum disorder (ASD) is a multifactorial neurodevelopmental disorder with complex molecular etiology. Since genetic causes account for less than 50% of ASD cases, novel approaches are required to overcome the challenges of charact...
Associations of general and specific psychopathology factors by age 35 with dementia after age 50: a Swedish population-based sibling comparison study [0.03%]
基于瑞典全民样本的同卵双生子研究：年龄35岁时一般及特定的精神病理学因子与50岁之后痴呆症之间的关联性研究报告
Yangjun Liu,Sara Hägg,Isabell Brikell et al.
Yangjun Liu et al.
Multiple psychiatric disorders are associated with later dementia, but it remains unclear whether these associations reflect a shared liability toward all psychiatric conditions (general psychopathology factor) or diagnosis-specific effects...
Time-dependent effects of rapid-acting antidepressants in iPSC-derived neurons from treatment-resistant depression and healthy volunteers [0.03%]
来自难治性抑郁患者和健康志愿者的诱导 pluripotent stem cell (iPSC)源神经元中快速抗抑郁药物的时间依赖性效应
Jenessa N Johnston,Gregory H Jones,Shiyong Peng et al.
Jenessa N Johnston et al.
Rapid-acting antidepressants like ketamine and serotonergic psychedelics show promise for treatment-resistant depression (TRD), but the molecular mechanisms that contribute to their therapeutic effects remain unclear. Induced pluripotent st...
Subtyping psychotic disorders using a data-driven approach reveals divergent cortical and cellular signatures [0.03%]
使用数据驱动方法对精神病障碍进行亚型分类揭示了不同的皮质和细胞特征
Lauren D Hill,Xi-Han Zhang,Baxter P Rogers et al.
Lauren D Hill et al.
Structural brain abnormalities in psychosis are well-replicated but heterogenous posing a barrier to uncovering the pathophysiology, etiology, and treatment of psychosis. To parse neurostructural heterogeneity and assess for the presence of...