Intensity and exposure proximity as determinants of differential stress-related health outcomes [0.03%]
强度和暴露持续时间作为差异性压力相关健康结果的决定因素
Maya Lebow,Ron Rotkopf,Elad Malik et al.
Maya Lebow et al.
Civilian populations under continuous traumatic stress (CTS) face long-term health consequences mediated primarily by glucocorticoid stress pathways. To assess the health impact of exposure to CTS and subsequent acute trauma, we conducted a...
Emotional scars: limbic brain processing alterations in adults with childhood abuse across mental health disorders [0.03%]
情感创伤：童年虐待在精神疾病成人患者边缘系统中的影像学痕迹
Mayuresh S Korgaonkar,Cheryl Tobler,Kim Felmingham et al.
Mayuresh S Korgaonkar et al.
Abuse experienced during childhood and adolescence significantly influences brain development and increases the risk of psychiatric disorders later in life. However, its long-term impact on emotion processing across psychiatric conditions r...
The short-chain fatty acid butyrate prevents gut-brain amyloid-β pathology and neuroinflammation in an Alzheimer mouse model [0.03%]
短链脂肪酸丁酸可通过预防肠道和大脑的β淀粉样蛋白病理改变及神经炎症来阻止阿尔茨海默病小鼠模型发病
Rodrigue Brossaud,Thibauld Oullier,Anne Bessard et al.
Rodrigue Brossaud et al.
Amyloid-β (Aβ) plays a critical role in Alzheimer's disease (AD) and its accumulation in the brain is pivotal to disease progression and precedes memory and neuronal loss. Besides the severely handicapping brain symptoms, AD patients disp...
Phenotypic diversity is caused by non-linear genetic interactions between two SNAREopathy genes [0.03%]
两个SNAREopathy基因之间的非线性遗传互作造成了表型多样性
Jovana Kovačević,Sébastien Houy,Johny Pires et al.
Jovana Kovačević et al.
Brain disorders caused by large effect mutations in single genes often present unexplained large symptom diversity, even among carriers of the same mutation. Here we examined genetic interactions as a possible explanation for this diversity...
The dynamics of AMPA receptors underlies the efficacy of ketamine in treatment resistant patients with depression [0.03%]
谷氨酸AMPAR受体动态是氯胺酮治疗难治性抑郁症疗效的基础
Waki Nakajima,Mai Hatano,Yohei Ohtani et al.
Waki Nakajima et al.
Approximately 30% of patients with depression suffer from treatment-resistant depression (TRD). Ketamine has shown antidepressant efficacy for TRD. While glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) has b...
Combining neurobiological markers and a sociodemographic risk score to predict adolescent depression - An IDEA RiSCo prospective cohort study [0.03%]
结合神经生物学标志物和人口社会学风险评分预测青少年抑郁——IDEA RiSCo前瞻性队列研究
Zuzanna Zajkowska,Naghmeh Nikkheslat,Pedro H Manfro et al.
Zuzanna Zajkowska et al.
The prevention of adolescent depression is a critical global challenge, hindered by the difficulty of identifying those at increased risk. We previously developed a sociodemographic-based risk score (IDEA-RS), which has proven to successful...
The global burden of mental and substance use disorders among adolescents and young adults [0.03%]
青少年和年轻人中的精神障碍和物质使用障碍的疾病负担
Xiangyu Zhao,Ligang Liu,Luofei Zhang et al.
Xiangyu Zhao et al.
Mental disorders and substance use disorders (SUDs) are significant public health challenges among adolescents and young adults (AYAs). This study quantified global and regional prevalence, disability-adjusted life-years (DALYs), and years ...
Targeted high-definition transcranial direct current stimulation over the left dorsolateral prefrontal cortex to modify cognitive biases in young adults with social anxiety: a randomized controlled trial [0.03%]
针对社交焦虑青年的大脑直接电流刺激以修正认知偏差：一项随机对照试验
Yi Yu,Hui Yu,Rumiao Pan et al.
Yi Yu et al.
Cognitive model suggests that social anxiety disorder (SAD) is maintained by persistent biases in attention, interpretation, and memory. Neuroscientific perspectives further implicate that hyperactivation of amygdala and default mode networ...
Examining glycation as a mediator linking bullying to psychotic experience and depressive symptom in adolescents [0.03%]
欺凌通过糖基化与青少年的幻觉和抑郁症状之间的关系研究
Mitsuhiro Miyashita,Zui C Narita,Jordan Devylder et al.
Mitsuhiro Miyashita et al.
Bullying is a critical social stressor with long-lasting adverse impacts on mental health throughout life. Identifying biological mediators between bullying and subsequent mental health problems could help mitigate the long-term negative im...
Functional brain abnormalities of cognitive impairments in schizophrenia indicating higher integration of working memory than other domains [0.03%]
精神分裂症工作记忆认知障碍的功能性脑异常高于其他领域指向更高的工作记忆综合能力
Xing Li,Jiaxin Zeng,Naici Liu et al.
Xing Li et al.
Brain functional alterations associated with overall cognitive impairments and specific cognitive domains defined by MATRICS Consensus Cognitive Battery (MCCB) and the similarities among them remain unclear in schizophrenia. Comprehensive l...