GluD1 is localized at cholinergic synapses and is an acetylcholine receptor [0.03%]
GluD1定位于胆碱能突触上并是一种乙酰胆碱受体
Poojashree B Chettiar,Kishore Kumar S Narasimhan,Siddhesh S Sabnis et al.
Poojashree B Chettiar et al.
The GluD1 receptor has many unusual features including expression at both excitatory and inhibitory synapses and a ligand binding domain capable of binding both D-serine and GABA. We have previously demonstrated that striatal GluD1 is criti...
Differential DNA methylation in blood as potential mediator of the association between ambient PM2.5 and cerebrospinal fluid biomarkers of Alzheimer's disease among a cognitively normal population-based cohort [0.03%]
基于人群的认知正常队列中血液DNA差分甲基化作为环境PM2.5与脑脊液生物标志物关联的潜在介导因素
Tszshan Ma,Jiaqi Liu,Donghai Liang et al.
Tszshan Ma et al.
Fine particulate matter (PM2.5) is a known risk factor for Alzheimer's disease (AD), with emerging evidence showing its effects detectable in the pre-clinical stage through cerebrospinal fluid (CSF) biomarkers of AD. While studies have link...
Anxiety influences the addictive feature of non-suicidal self-injury behavior via somatic symptom in adolescents with major depressive disorder [0.03%]
焦虑通过躯体化症状影响青少年抑郁障碍患者自伤行为的成瘾性
Xiaoli Liu,Song Yuan,Wenwu Zhang et al.
Xiaoli Liu et al.
Adolescents with major depressive disorder (MDD) frequently engage in repetitive non-suicidal self-injury (NSSI), with a subset developing addictive patterns; however, the underlying mechanisms remain unclear. In this present study, 363 hos...
Hierarchical neural variability reveals adaptive and maladaptive mechanisms of non-suicidal self-injury [0.03%]
层次神经变异性揭示了非自杀性自我伤害的适应性和非适应性机制
Jian Li,Ya Xie,Fengmin Ni et al.
Jian Li et al.
Non-suicidal self-injury (NSSI) is a prevalent and clinically urgent condition in adolescence, marked by impairments in cognitive flexibility-a capacity thought to be supported by neural variability. However, most research to date has focus...
Efficacy of pharmacological and microbiota-based therapies in preclinical models of autism spectrum disorder: a systematic review [0.03%]
自闭症谱系障碍的药理和微生物组治疗方法在临床上的疗效：系统性综述
Arnas Kunevičius,Kinga Gawlińska,Aurelijus Burokas et al.
Arnas Kunevičius et al.
Background: Autism spectrum disorder (ASD) is a multifactorial neurodevelopmental condition in which pharmacological and microbiota-targeted interventions are emerging as promising therapeutic avenues. Animal models are t...
NgR-Dependent plasticity in a dCA3CaMKIIα → VTADA → NAc circuit underlies stress resilience and susceptibility [0.03%]
NgR依赖的dCA3CaMKIIα→VTADA→NAc回路可塑性调节应激忍耐和易感性的机制研究
Jun Zhao,Haifeng Lian,Bin Wang et al.
Jun Zhao et al.
The Nogo receptor (NgR), a core receptor for myelin-derived axon growth inhibitors, has been implicated not only in the regulation of synaptic plasticity but also in the pathogenesis of various neuropsychiatric disorders. However, its speci...
Alcohol abstinence precipitates alcohol seeking and aversion-resistant intake in association with increased BNST activity [0.03%]
禁酒可以诱发与BNST活性增加有关的觅酒行为和不为厌恶所阻的饮酒行为
Marie A Doyle,Hye Jean Yoon,Megan E Altemus et al.
Marie A Doyle et al.
Alcohol Use Disorder (AUD) is defined by a common diagnostic framework, yet individuals show diverse drinking patterns and relapse vulnerabilities during abstinence, reflecting neurobiological heterogeneity. The bed nucleus of the stria ter...
Genetics of major depressive disorder in a homogeneous population with uniform phenotyping [0.03%]
遗传同质性抑郁障碍的遗传学研究
Floris Huider,Yuri Milaneschi,René Pool et al.
Floris Huider et al.
Harmonized phenotyping and diverse population-specific studies are crucial for advancing gene discovery in psychiatric genetics. We conducted a genome-wide association (GWAS) mega-analysis of DSM-defined lifetime major depressive disorder (...
Marko Jörg,Lukas Walz,Sebastian Nathal et al.
Marko Jörg et al.
Alzheimer's disease (AD) is a heterogeneous neurodegenerative disorder, highlighting the need to identify novel molecular regulators for effective treatment development. Angiogenin (ANG), a stress-responsive ribonuclease that inhibits apopt...
Reduced BCL2 level in astrocytes contributes to blood-brain barrier disruption in the striatum of offspring exposed to maternal preeclampsia [0.03%]
低BCL2水平导致星形胶质细胞功能障碍和纹状体血脑屏障破坏
Jiashuo Zhang,Mengting Zhang,Zhengyang Zhao et al.
Jiashuo Zhang et al.
Maternal preeclampsia (PE) contributes to neurodevelopmental disorders. However, the underlying molecular mechanism remains unclear. We investigated the potential biological regulatory mechanisms by establishing an animal model and primary ...