Discovery of a selective CDK7 PROTAC against acute leukemia with low platelet toxicity [0.03%]
一种选择性CDK7降解剂PROTAC用于急性白血病并具有低血小板毒性
Yutong Tu,Xiaojia Cai,Zhaofan Tao et al.
Yutong Tu et al.
Cyclin-dependent kinase 7 (CDK7), a key regulator of cell cycle progression and transcriptional control, has emerged as a promising therapeutic target in acute leukemia. While CDK7 inhibitors have shown antileukemic activity, their clinical...
The impact of periconceptional folate on the DNA methylome of acute lymphoblastic leukemia [0.03%]
妊娠前期叶酸对急性淋巴细胞白血病DNA甲基化的影响研究
Eric M Nickels,Libby M Morimoto,Alice Y Kang et al.
Eric M Nickels et al.
Periconceptional folate intake decreases the risk of pediatric acute lymphoblastic leukemia (ALL); however, the mechanism is not fully understood. We sought to identify sites of DNA methylation measured at birth both responsive to periconce...
Flare of clonal hematopoiesis, TP53 expansion and prior melphalan drive post-CAR-T myeloid disorders in multiple myeloma [0.03%]
克隆造血急性发作、TP53扩增和前期美法仑驱动多发性骨髓瘤CAR-T治疗后的髓系病态改变
Johannes Waldschmidt,David Fandrei,Judith S Hecker et al.
Johannes Waldschmidt et al.
Beyond mechanisms: toward patient-centered choices in BTKi-venetoclax fixed-duration therapy for CLL [0.03%]
超越机制：面向患者的BTKi-维纳妥拉固定疗程治疗CLL的选择
Francesca R Mauro,David Allsup,Stefano Molica
Francesca R Mauro
Yuan Yang,Zengwei Tang,Qinglin Hu et al.
Yuan Yang et al.
Although targeting the ubiquitin-like PHD and RING finger domain-containing protein 1 (UHRF1) has shown promise in treating a number of diseases, its function in mantle cell lymphoma (MCL) and its regulatory connection to SOX11 are yet unkn...
Functional cooperation between the B-cell receptor and NOTCH1 in regulating metabolic reprogramming in chronic lymphocytic leukemia [0.03%]
B细胞受体与NOTCH1在慢性淋巴细胞白血病代谢重编程中的功能协作作用研究
Amelia Fascì,Francesco Edoardo Vallone,Nahal Nabelsi et al.
Amelia Fascì et al.
Mutations in NOTCH1, which occur in ~10% of Chronic Lymphocytic Leukemia (CLL) patients at diagnosis, are typically associated with unmutated (UM) B-cell receptor (BCR) subsets and define patients with earlier treatment need. Using primary ...
KMT2A-rearranged B-lymphoblastic lymphomas are skewed towards a more mature developmental stage [0.03%]
易位性KMT2A重排B淋巴母细胞淋巴瘤偏向于更成熟的发育阶段
Ingram Iaccarino,Alina M Hartmann,Fatih Yalcin et al.
Ingram Iaccarino et al.
CD70/CD27 signaling promotes the pathogenesis of multiple myeloma and represents a promising therapeutic target [0.03%]
CD70/CD27信号转导促进多发性骨髓瘤的发生发展代表了一个有希望的治疗靶点
Stefan Forster,Chantal Reinhardt,Maxime Boy et al.
Stefan Forster et al.
The increasing therapeutic options for multiple myeloma (MM) have significantly improved long-term survival for many patients. However, disease progression remains inevitable due to the emergence of drug-resistant myeloma cell populations, ...
AI-based hematological malignancy prediction from peripheral blood smears in a large diagnostic laboratory cohort [0.03%]
基于人工智能的大型诊断实验室外周血涂片血液系统恶性肿瘤预测队列研究
Muhammed Furkan Dasdelen,Ivan Kukuljan,Peter Lienemann et al.
Muhammed Furkan Dasdelen et al.
Validation of Prospective Cutaneous Lymphoma International Prognostic Index for advanced cutaneous lymphoma in a multicenter Chinese cohort [0.03%]
中国多中心皮肤淋巴瘤队列中前瞻性验证皮肤淋巴瘤国际预后指数
Zhuojing Chen,Yeping Ruan,Yimeng Wang et al.
Zhuojing Chen et al.