Multi-omics analysis of pediatric minimally differentiated acute myeloid leukemia reveals RUNX1-driven stemness and chemoresistance [0.03%]
Tatsuya Kamitori,Satoshi Saida,Kazuki Mitani et al.
Tatsuya Kamitori et al.
Minimally differentiated acute myeloid leukemia (AML-M0) is a rare and therapeutically challenging subgroup of AML characterized by immature hematopoietic stem cell-like features. To uncover the molecular basis, we conducted a comprehensive...
Reduced-intensity reinduction for children and young persons with relapsed acute lymphoblastic leukemia [0.03%]
Angus Hodder,Avijeet Mishra,Amir Enshaei et al.
Angus Hodder et al.
Chronic myelomonocytic leukemia beyond the marrow: biology, patterns, and management of extramedullary disease [0.03%]
Manal Ahmidouch,Priya Deshpande,Christian Salib et al.
Manal Ahmidouch et al.
Chronic myelomonocytic leukemia (CMML) is an MDS/MPN overlap neoplasm defined by monocytosis, clonal hematopoiesis, and marrow dysplasia, with outcomes ranging from indolent cytopenic disease to aggressive proliferative phenotypes with earl...
A small proportion of CD8 T cells expand robustly when stimulated with BCMAxCD3 bispecific T-cell engagers in vitro [0.03%]
Kumi Shibata,Kazuhito Tsutsumi,Hiraku Murakami et al.
Kumi Shibata et al.
Nawachai Lertvivatpong,Hiroto Inaba
Nawachai Lertvivatpong
Treatment outcomes for pediatric acute lymphoblastic leukemia (ALL) have improved considerably, with overall survival rates in high-income countries now exceeding 90% as a result of the introduction of risk-adapted chemotherapy and improved...
Development and validation of the predictive aplastic score system (PASS): a simplified tool to diagnose acquired aplastic anemia in adults [0.03%]
Gabriel Aleixo,HeeJin Cheon,Jiayin Zheng et al.
Gabriel Aleixo et al.
Acquired aplastic anemia (AA) can present similarly to inherited bone marrow failure syndromes (IBMFS) but treatment differs. AA diagnosis relies on excluding IBMFS; however, genetic testing is not always available, may delay care or be inc...
Prevalence and characterization of germline RAS pathway variants in children with chronic myeloid leukemia [0.03%]
Tabita Ghete,Laura Gaschler,Manuela Krumbholz et al.
Tabita Ghete et al.
ASC4OPT: asciminib treatment optimization study in patients with chronic myeloid leukemia in chronic phase previously treated with two or more tyrosine kinase inhibitors [0.03%]
Andreas Hochhaus,Philipp le Coutre,Dragana Milojkovic et al.
Andreas Hochhaus et al.
The ASC4OPT non-comparative phase 3b study (NCT04948333) evaluates asciminib once daily (QD) or twice daily (BID) in chronic myeloid leukemia in chronic phase (CML-CP) treated with ≥2 tyrosine kinase inhibitors (TKIs). This study enrolled ...
The spectrum of immunoglobulin heavy chain enhancer hijacking in chronic lymphocytic leukemia [0.03%]
Cosima Drewes,Cristina López,Nnamdi Okeke et al.
Cosima Drewes et al.
Activation of oncogenes by hijacking immunoglobulin gene loci (IG) enhancers via chromosomal translocation is a common pathogenetic mechanism in B-cell malignancies, affecting 5-10% of chronic lymphocytic leukemia (CLL). The oncogenic partn...
Hemophagocytic lymphohistiocytosis in HIV-related lymphomas: a multicentre retrospective cohort study [0.03%]
Pascal Migaud,Alessia Dalla Pria,Daniela Drauz et al.
Pascal Migaud et al.