Isatuximab induces antitumor activity in blastic plasmacytoid dendritic cell neoplasm through cellular cytotoxicity [0.03%]
艾沙替莫通过细胞毒性诱导浆细胞样树突状细胞肿瘤的抗肿瘤作用
Nobuhiko Yamauchi,Yuko Mishima,Tomoko Takayama et al.
Nobuhiko Yamauchi et al.
PRMT1 facilitates the tumorigenesis of chronic lymphocytic leukemia by regulating methylation of MAST1 [0.03%]
脯氨酰-tRNA合成酶(PRMT1)调控MAST1甲基化促进慢性淋巴细胞性白血病发生发展
Zheng Tian,Pan Gao,Yang Zhang et al.
Zheng Tian et al.
Protein arginine methyltransferase 1 (PRMT1) serves as a crucial regulator of post-translational modifications of proteins. While PRMT1 has been implicated in the progression of various cancers, its specific role in chronic lymphocytic leuk...
BCR::ABL1 tyrosine kinase inhibitors induce ribosome collisions to activate ZAK-dependent ribotoxic stress and apoptosis in chronic myeloid leukemia [0.03%]
BCR::ABL1酪氨酸激酶抑制剂诱导核糖体碰撞以激活ZAK依赖的核糖毒性应激和慢性粒细胞白血病中的凋亡
Jumin Park,Soo-Hyun Kim,Jongmin Park et al.
Jumin Park et al.
Ribosome collisions act as molecular sensors of cellular stress, yet their role in disease physiology remains unclear. Here, we demonstrate that inhibition of the oncogenic kinase BCR::ABL1 in chronic myeloid leukemia (CML) cells induces ri...
The adverse prognostic impact of HMGCLL1 gene variants can be abrogated by frontline second-generation tyrosine kinase inhibitor therapy in patients with chronic myeloid leukemia [0.03%]
BCR-ABL次世代酪氨酸激酶抑制剂的一线治疗能够消除慢性髓性白血病患者不良预后基因变异的影响
Maria Agustina Perusini,Katia Pagnano,Carolina Pavlovsky et al.
Maria Agustina Perusini et al.
Prognostic significance of clinical risk models and genomic alterations in Waldenström macroglobulinemia before or after the BTK inhibitor era [0.03%]
布鲁顿酪氨酸激酶抑制剂时代之前或之后华氏巨球蛋白血症临床风险模型和基因组改变的预后意义
Yuting Yan,Weihao Chen,Ying Yu et al.
Yuting Yan et al.
Waldenström macroglobulinemia (WM) is a rare indolent B-cell lymphoma with marked clinical and molecular heterogeneity. Clinical risk models, including IPSSWM, rIPSSWM, and MSSWM, were developed prior to the widespread use of Bruton tyrosi...
Differential mitochondrial priming by BCR::ABL1 in B-cell precursor acute lymphoblastic leukemia [0.03%]
B细胞急性淋巴细胞白血病中BCR::ABL1诱导的线粒体差异活化现象
Hanna Kirchhoff,Caroline Schoenherr,Lisa Fleischer et al.
Hanna Kirchhoff et al.
Myeloproliferative neoplasms with concomitant chronic myeloid leukemia are associated with TKI resistance and poor outcomes [0.03%]
并发慢性粒细胞白血病的髓系肿瘤与TKI耐药和预后不良相关
Laura Li Gagnon,Andrea Duminuco,Fabio Stagno et al.
Laura Li Gagnon et al.
Chronic myeloid leukemia (CML) and Philadelphia (Ph)-negative myeloproliferative neoplasms (MPN) are generally distinct clonal disorders, with the co-occurrence of BCR::ABL1 rearrangement with concomitant Ph-negative MPN rarely reported. He...
Synergizing hypomethylating agents with off-the-shelf CD70-targeted chimeric antigen receptor-engineered natural killer T cells for the treatment of acute myeloid leukemia [0.03%]
低甲基化药物与即用型CD70靶向嵌合抗原受体修饰的自然杀伤T细胞结合治疗急性髓系白血病
Yan-Ruide Li,Xinyuan Shen,Yuning Chen et al.
Yan-Ruide Li et al.
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy characterized by the uncontrolled expansion of undifferentiated myeloid precursors in the bone marrow. Hypomethylating agents (HMAs) such as azacitidine and decitabine can...
Genetic alterations and measurable residual disease in core binding factor acute myeloid leukemia [0.03%]
遗传学改变和可测量的残余病在核心结合急性髓系白血病中的研究
Loïc Vasseur,Matthieu Duchmann,Nicolas Duployez et al.
Loïc Vasseur et al.
Measurable residual disease (MRD) is a major prognostic factor in Core Binding Factor (CBF) AML. KIT or FLT3 mutations also have prognostic relevance, but little is known about their prognostic value when accounting for MRD. We analyzed the...
A Perturb-seq map of a differentiation hub reveals synergistic vulnerabilities in KMT2A-rearranged acute myeloid leukemia [0.03%]
基于Perturb-seq绘制的分化枢纽图揭示了KMT2A重排急性髓系白血病的协同易感性
Sajesan Aryal,Brittany M Curtiss,Xinyue Zhou et al.
Sajesan Aryal et al.
KMT2A-rearranged acute myeloid leukemia is driven by epigenetic dependencies yet remains clinically resistant to therapies targeting individual regulators, indicating that resistance reflects compensatory regulation across an epigenetic net...