Self-sufficient redox biotransformation of lignin-related benzoic acids with Aspergillus flavus [0.03%]
黄曲霉催化联苯酸类化合物的自给型生物转化反应
Martín A Palazzolo,María L Mascotti,Elizabeth S Lewkowicz et al.
Martín A Palazzolo et al.
Aromatic carboxylic acids are readily obtained from lignin in biomass processing facilities. However, efficient technologies for lignin valorization are missing. In this work, a microbial screening was conducted to find versatile biocatalys...
Application of enzymatic apple pomace hydrolysate to production of 2,3-butanediol by alkaliphilic Bacillus licheniformis NCIMB 8059 [0.03%]
酶解苹果果渣在产碱性芽孢杆菌NCIMB 8059发酵生产丁二醇中的应用研究
Aneta M Białkowska,Ewa Gromek,Joanna Krysiak et al.
Aneta M Białkowska et al.
2,3-Butanediol (2,3-BD) synthesis by a nonpathogenic bacterium Bacillus licheniformis NCIMB 8059 from enzymatic hydrolysate of depectinized apple pomace and its blend with glucose was studied. In shake flasks, the maximum diol concentration...
Esther K Schmitt,D Hoepfner,P Krastel
Esther K Schmitt
From the start of the pharmaceutical research natural products played a key role in drug discovery and development. Over time many discoveries of fundamental new biology were triggered by the unique biological activity of natural products. ...
Increased ethanol production by deletion of HAP4 in recombinant xylose-assimilating Saccharomyces cerevisiae [0.03%]
利用重组木糖同化酿酒酵母删除HAP4基因以提高乙醇产量
Akinori Matsushika,Tamotsu Hoshino
Akinori Matsushika
The Saccharomyces cerevisiae HAP4 gene encodes a transcription activator that plays a key role in controlling the expression of genes involved in mitochondrial respiration and reductive pathways. This work examines the effect of knockout of...
Michael J Smanski,Daniel C Schlatter,Linda L Kinkel
Michael J Smanski
Technological improvements have accelerated natural product (NP) discovery and engineering to the point that systematic genome mining for new molecules is on the horizon. NP biosynthetic potential is not equally distributed across organisms...
Louis K Ho,Justin R Nodwell
Louis K Ho
Environmental microbes produce biologically active small molecules that have been mined extensively as antibiotics and a smaller number of drugs that act on eukaryotic cells. It is known that there are additional bioactives to be discovered...
Microbial conversion of pyrolytic products to biofuels: a novel and sustainable approach toward second-generation biofuels [0.03%]
热解产物的微生物转化生产生物燃料——一种制备第二代生物燃料的新颖而可持续的方法
Zia Ul Islam,Yu Zhisheng,El Barbary Hassan et al.
Zia Ul Islam et al.
This review highlights the potential of the pyrolysis-based biofuels production, bio-ethanol in particular, and lipid in general as an alternative and sustainable solution for the rising environmental concerns and rapidly depleting natural ...
Identification and activation of novel biosynthetic gene clusters by genome mining in the kirromycin producer Streptomyces collinus Tü 365 [0.03%]
通过基因组挖掘法在链黴菌素coliensis Tü 365中鉴定和激活新型生物合成基因簇
Dumitrita Iftime,Andreas Kulik,Thomas Härtner et al.
Dumitrita Iftime et al.
Streptomycetes are prolific sources of novel biologically active secondary metabolites with pharmaceutical potential. S. collinus Tü 365 is a Streptomyces strain, isolated 1972 from Kouroussa (Guinea). It is best known as producer of the a...
Control of carbon flux to glutamate excretion in Klebsiella pneumoniae: the role of the indigenous plasmid and its encoded isocitrate dehydrogenase [0.03%]
肺炎克雷伯氏菌中碳流向谷氨酸排泄的调控：土著质粒及其编码的异柠檬酸脱氢酶的作用
Mansi El-Mansi,Francois Trappey,Ewan Clark et al.
Mansi El-Mansi et al.
Klebsiella pneumoniae (NCTC, CL687/80) harbors a large indigenous plasmid (p(C3)), which in addition to encoding for citrate utilization, proline synthesis and glutamate excretion, it uniquely carries the structural gene (icd); encoding iso...
Sequence and structure-based comparative analysis to assess, identify and improve the thermostability of penicillin G acylases [0.03%]
基于序列和结构的比较分析以评估、识别并提高青霉素G酰化酶的耐热性
Priyabrata Panigrahi,Deepak Chand,Ruchira Mukherji et al.
Priyabrata Panigrahi et al.
Penicillin acylases are enzymes employed by the pharmaceutical industry for the manufacture of semi-synthetic penicillins. There is a continuous demand for thermostable and alkalophilic enzymes in such applications. We have carried out a co...