Combinatorial application of two aldehyde oxidoreductases on isobutanol production in the presence of furfural [0.03%]
两种甲醛氧化还原酶在糠醛存在下组合应用提高异丁醇产量
Hyung-Min Seo,Jong-Min Jeon,Ju Hee Lee et al.
Hyung-Min Seo et al.
Furfural is a toxic by-product formulated from pretreatment processes of lignocellulosic biomass. In order to utilize the lignocellulosic biomass on isobutanol production, inhibitory effect of the furfural on isobutanol production was inves...
Urine-powered microbial fuel cell using a hyperpiliated pilT mutant of Pseudomonas aeruginosa [0.03%]
用Pseudomonas aeruginosa的超长菌毛突变体pilT构建尿液驱动型微生物燃料电池
Devesh Dadhich Shreeram,Daniel J Hassett,Dale W Schaefer
Devesh Dadhich Shreeram
This report documents the first observation of a urine-powered microbial fuel cell operating with a genetically engineered bacterial strain. Under identical conditions, a pilT mutant of the Gram-negative bacterium Pseudomonas aeruginosa sho...
Introduction to the Special Issue: "Natural Product Discovery and Development in the Genomic Era" [0.03%]
专刊介绍：“基因组时代中的天然产物发现与开发”
Richard H Baltz,Haruo Ikeda,Leonard Katz et al.
Richard H Baltz et al.
Efficient production of gamma-aminobutyric acid using Escherichia coli by co-localization of glutamate synthase, glutamate decarboxylase, and GABA transporter [0.03%]
通过谷氨酸合成酶、谷氨酸脱羧酶和GABA转运蛋白的协同作用高效生产γ-氨基丁酸
Van Dung Pham,Sivachandiran Somasundaram,Seung Hwan Lee et al.
Van Dung Pham et al.
Gamma-aminobutyric acid (GABA) is an important bio-product, which is used in pharmaceutical formulations, nutritional supplements, and biopolymer monomer. The traditional GABA process involves the decarboxylation of glutamate. However, the ...
From the New Editor-in-Chief [0.03%]
新主编来信
Ramon Gonzalez
Ramon Gonzalez
Engineering of isoamylase: improvement of protein stability and catalytic efficiency through semi-rational design [0.03%]
异亮氨酸酶的工程设计：通过半理性设计提高蛋白质稳定性和催化效率
Youran Li,Liang Zhang,Zhongyang Ding et al.
Youran Li et al.
Isoamylase catalyzes the hydrolysis of α-1,6-glycosidic linkages in glycogen, amylopectin and α/β-limit dextrins. A semi-rational design strategy was performed to improve catalytic properties of isoamylase from Bacillus lentus. Three res...
Culture-independent discovery of natural products from soil metagenomes [0.03%]
土壤元基因组中非培养微生物来源的天然产物的鉴定与挖掘
Micah Katz,Bradley M Hover,Sean F Brady
Micah Katz
Bacterial natural products have proven to be invaluable starting points in the development of many currently used therapeutic agents. Unfortunately, traditional culture-based methods for natural product discovery have been deemphasized by p...
Anti-tuberculosis lead molecules from natural products targeting Mycobacterium tuberculosis ClpC1 [0.03%]
针对结核分枝杆菌ClpC1的抗结核活性天然产物先导化合物筛选
Hanki Lee,Joo-Won Suh
Hanki Lee
Tuberculosis (TB) is a serious and potentially fatal disease caused by Mycobacterium tuberculosis (M. tb). The occurrence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) M. tb is a significant public health concern because...
Glutathione production by recombinant Escherichia coli expressing bifunctional glutathione synthetase [0.03%]
表达谷胱甘肽双功能合成酶的重组大肠杆菌生产谷胱甘肽
Dezheng Wang,Cheng Wang,Hui Wu et al.
Dezheng Wang et al.
Glutathione (GSH) is an important bioactive substance applied widely in pharmaceutical and food industries. Due to the strong product inhibition in the GSH biosynthetic pathway, high levels of intracellular content, yield and productivity o...
Natural product derived insecticides: discovery and development of spinetoram [0.03%]
天然产物杀虫剂的发现与开发——斑地螺蝇萜醇类化合物Spinetoam的研究
Ute Galm,Thomas C Sparks
Ute Galm
This review highlights the importance of natural product research and industrial microbiology for product development in the agricultural industry, based on examples from Dow AgroSciences. It provides an overview of the discovery and develo...