Activating NRF2E79Q mutation alters the differentiation of human non-small cell lung cancer [0.03%]
NRF2E79Q激活突变改变人类非小细胞肺癌的分化
Samera H Hamad,Hansa Joshi,T Hess et al.
Samera H Hamad et al.
The NRF2 signaling pathway promotes tumor initiation, progression and resistance to chemotherapy, radiation therapy and immune checkpoint inhibitors. The mechanisms underlying the biology of NRF2-active tumors are varied and include altered...
GPR107: A key driver of breast cancer invasion and metastasis through collagen IV modulation [0.03%]
GPR107通过调节IV型胶原蛋白驱动乳腺癌侵袭和转移
Ruyue Xu,Jiahui Liang,Shuyuan Zhang et al.
Ruyue Xu et al.
Breast cancer is a leading cause of cancer-related death in women, and the development of effective treatments for advanced disease remains a critical challenge. Metastasis, the spread of cancer cells to distant sites, is the major cause of...
Decoding BRCA1 promoter hypermethylation: a new frontier in understanding sporadic breast cancer [0.03%]
解读BRCA1启动子高甲基化：理解散发性乳腺癌的新前沿
Dipyaman Patra,Geetu Rose Varghese,Vishnu Sunil Jaikumar et al.
Dipyaman Patra et al.
The role of epimutations in sporadic oncogenesis has been a hot topic of debate and speculation, as hereditary mutations account for merely 5-10% of cancers. One such epimutation, BRCA1 promoter hypermethylation (BPM), is associated with BR...
Unveiling the role of the extracellular matrix in the osteosarcoma tumor microenvironment through integrated transcriptomics and experimental validation [0.03%]
整合转录组和实验验证解析骨肉瘤肿瘤微环境基质的作用
Yuyang Liu,Yuchen Han,Zixuan Guo et al.
Yuyang Liu et al.
Osteosarcoma (OS), the most common malignant bone tumor, is characterized by heterogeneous tumor cells and abundant microenvironmental components. The extracellular matrix (ECM)-a complex and dynamic network surrounding tumor cells-plays a ...
pNaktide reverses metabolic reprogramming and disease progression of ATP1A1-deficiency clear cell renal cell carcinoma [0.03%]
pNaktide逆转ATP1A1缺乏的透明细胞肾细胞癌的代谢重编程和疾病进展
Yinghong Zhao,Jialing Lv,Wen Zhang et al.
Yinghong Zhao et al.
ATP1A1 has been reported to exhibit differential expression across various tumors; however, its specific role in clear cell renal cell carcinoma (ccRCC) remains uncharted. This study investigates the role of ATP1A1 in ccRCC, assessing its p...
Demethoxycurcumin suppresses HK2-mediated glycolysis by targeting PTEN/Akt signaling [0.03%]
姜黄素衍生物_demethoxycurcumin_通过作用于PTEN/Akt信号轴抑制HK2介导的糖酵解
Jinzhuang Liao,Shiming Tan,Shuangze Han et al.
Jinzhuang Liao et al.
Aerobic glycolysis is a hallmark of tumor cells, with the expression of glycolytic enzymes often being upregulated in many cancers, leading to enhanced metabolic activity. Among the key rate-limiting enzymes in this process, Hexokinase 2 (H...
Demethoxycurcumin suppresses HK2-mediated glycolysis by targeting PTEN/Akt signaling [0.03%]
_demethoxycurcumin通过靶向PTEN/Akt信号抑制HK2介导的糖酵解
Jinzhuang Liao,Shiming Tan,Shuangze Han et al.
Jinzhuang Liao et al.
Aerobic glycolysis is a hallmark of tumor cells, with the expression of glycolytic enzymes often being upregulated in many cancers, leading to enhanced metabolic activity. Among the key rate-limiting enzymes in this process, Hexokinase 2 (H...
New insights into the classification of the RAC1 P29S hotspot mutation in melanoma as an oncogene [0.03%]
新的视角揭示黑色素瘤中RAC1 P29S热点突变作为癌基因的分类
Amin Mirzaiebadizi,Mohammad Reza Ahmadian
Amin Mirzaiebadizi
The RAC1P29S hotspot mutation, which is prevalent in melanoma, drives tumorigenesis by promoting the persistent activation of RAC1. This mutation enhances molecular interactions, and hyperactivates key signaling pathways, making RAC1P29S a ...
Paricalcitol and hydroxychloroquine modulates extracellular matrix and enhance chemotherapy efficacy in pancreatic cancer [0.03%]
派卡钙vitD3和羟氯喹通过调节细胞外基质来增强胰腺癌化疗的疗效
Dhana Sekhar Reddy Bandi,Sujith Sarvesh,Jeremy Foote et al.
Dhana Sekhar Reddy Bandi et al.
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor prognosis and limited therapeutic options. In a previous publication, our group defined some of the mechanisms that vitamin D analogue paricalcitol (P) and hydr...
Bacillus Calmette-Guerin induces CD8+ T cell infiltration and suppresses tumor progression in microsatellite stable colorectal cancer by downregulating ARID1A [0.03%]
卡介苗通过下调ARID1A诱导CD8+t细胞浸润并抑制微卫星稳定型结直肠癌的发展
Zhiyue Xie,Nan Peng,Zhihua Pan et al.
Zhiyue Xie et al.
Neoadjuvant immunotherapy demonstrates limited efficacy in microsatellite-stable (MSS) colorectal cancer (CRC). In vivo observations reveal that Bacillus Calmette-Guérin (BCG) can inhibit the progression of MSS-CRC and downregulate ARID1A ...