CLK3 regulates tumor angiogenesis by modulating HIF1α ubiquitination [0.03%]
CLK3通过调节HIF1α的泛素化来调控肿瘤血管生成
Jing Shen,Wen Zhang,Zhiqiang Chu et al.
Jing Shen et al.
Tumor angiogenesis is a critical driver of cancer progression and is regulated by a complex network of signaling pathways. However, limited therapeutic efficacy and the emergence of drug resistance remain significant obstacles, necessitatin...
HOXC11 promotes head and neck squamous cell carcinomas (HNSCC) progression by regulating SPHK1 through the Wnt signaling pathway [0.03%]
HOXC11通过Wnt信号通路调节SPHK1促进头颈部鳞状细胞癌的发展进展
Jing Zhang,Qionghui Wu,Jingyuan Liu et al.
Jing Zhang et al.
The discovery of potential targets in Head and neck squamous cell carcinomas (HNSCC) through molecular and mechanism analyses is crucial for understanding and treating this disease. This study utilized rigorous methods, including cell lines...
Glypican-3-targeted therapy in hepatocellular carcinoma: biological insights and therapeutic strategies [0.03%]
肝癌中针对Gpc3的治疗：生物学见解和治疗策略
Na Li,Shurong Li,Peng Cao et al.
Na Li et al.
Glypican-3 (GPC3) is an oncofetal cell surface proteoglycan that is highly expressed in hepatocellular carcinoma (HCC) and largely absent from normal adult tissues, making it an attractive target for gene and cell therapies. A broad range o...
Target therapeutic exploitation of engineered exosome-mediated delivery of ncRNAs in cancer [0.03%]
工程化外泌体介导的ncRNA递送在癌症治疗中的潜在应用研究
Fatemeh Chaharlang,Nafiseh Mahdipour,Sana Alizadeh Rami et al.
Fatemeh Chaharlang et al.
Non-coding RNAs, as microRNAs, long non-coding RNAs, and circular RNAs, are significant modulators of tumor biology and gene expression. miRNAs primarily regulate gene expression at the post-transcriptional level, whereas lncRNAs influence ...
Targeting RAB27A-mediated small extracellular vesicle secretion via CRISPR-Cas9 negatively affects proliferation and metastasis in both in vitro and in vivo SCLC models [0.03%]
基于CRISPR-Cas9针对RAB27A介导的小细胞肺癌来源的细胞外小囊泡分泌的作用研究
Onur Tokgün,Kubilay İnci,Aziz Gültekin et al.
Onur Tokgün et al.
Small cell lung cancer (SCLC) comprises 15% of lung cancers with a capacity for early and distant metastatic development, high proliferative capacity, and poor survival rates. Ionizing radiation and chemotherapy are effective against early-...
CagA promotes gastric cancer stemness and metastasis via DNMT1-mediated epigenetic silencing of BEX1 [0.03%]
CagA通过DNMT1介导的BEX1表观遗传沉默促进胃癌干细胞特性及转移
Yan Wang,Dajun Chen,Shuai Qian et al.
Yan Wang et al.
Helicobacter pylori (H. pylori) cytotoxin-associated gene A (CagA) critically contributes to gastric cancer (GC) pathogenesis, though its epigenetic control of cancer stemness is incompletely characterized. This study establishes that CagA ...
Retraction Note: Downregulation of SBF2-AS1 functions as a tumor suppressor in clear cell renal cell carcinoma by inhibiting miR-338-3p-targeted ETS1 [0.03%]
撤回 notice:通过抑制ETS1发挥肿瘤抑制作用的SBF2-AS1在透明细胞肾细胞癌中的下调功能
Xiuqin Yang,Yuanyuan Zhang,Haiying Fan
Xiuqin Yang
Inhibiting CXCL12/CXCR4 axis enhances T cell activity in gastric cancer [0.03%]
抑制CXCL12/CXCR4轴可增强胃癌中的T细胞活性
Fengyu Ling,Meibiao Zhang,Jia Kuang et al.
Fengyu Ling et al.
This study aimed to investigate how the CXCL12/CXCR4 axis facilitates immune evasion in gastric cancer (GC) by enhancing cellular communication between cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs) using singl...
LD-associated signatures identified by perilipin-based proximity labeling proteomics reveal GNA14 as a therapeutic and prognostic target in renal cell carcinoma [0.03%]
基于 perilipin 的邻近标记蛋白质组学鉴定的 LD 相关标志物揭示了 GNA14 是肾细胞癌的治疗和预后靶点
Yuankang Feng,Xinran Zhang,Shiyue Zhang et al.
Yuankang Feng et al.
Renal cell carcinoma (RCC), especially clear cell RCC (ccRCC), is characterized by metabolic reprogramming, notably disordered lipid metabolism and prominent intracellular lipid droplet accumulation. In addition to abnormal triglyceride and...
PYGO2 is overexpressed in multiple myeloma patients with 1q21 amplification, driving plasma cell proliferation and cell cycle progression [0.03%]
MYC下游基因PYGO2在多发性骨髓瘤中的异常高表达及其促肿瘤作用研究
Nicolas Thomas Iannozzi,Paola Storti,Rosanna Vescovini et al.
Nicolas Thomas Iannozzi et al.
Chromosome 1q21 copy number alterations (1q21+) are among the most frequent secondary events in multiple myeloma (MM), correlating with poor prognosis and therapy resistance. However, the molecular drivers of this lesion remain poorly defin...